Results 241 to 250 of about 276,610 (317)

High-throughput synaptic connectivity mapping using in vivo two-photon holographic optogenetics and compressive sensing. [PDF]

Nat Neurosci
Chen IW, Chan CY, Navarro P, de Sars V, Ronzitti E, Oweiss K, Tanese D, Emiliani V.   +7 more
europepmc   +1 more source

Cyp2e1 deletion in mice increases sensitivity to ethanol‐induced motor impairment and escalation of drinking behavior in the chronic intermittent ethanol model

Alcohol, Clinical and Experimental Research, EarlyView.
This study investigates the impact of global Cyp2e1 knockout and wild‐type mice to explore the effect of altered ethanol metabolism on behavior and gene expression. Knockout mice demonstrated altered alcohol‐related pathways, increased ethanol sensitivity, and escalated drinking.
Hyland C. Gonzalez, Kelly R. Misare, Kate E. Glorioso, Joe R. Delaney, Howard C. Becker, Marcelo F. Lopez, Patrick J. Mulholland, Jessica H. Hartman   +7 more
wiley   +1 more source

A synapse perspective on the function of the amyloid precursor protein. [PDF]

Sci Prog
Kruse P, Eichler A, Klukas L, Lenz M.
europepmc   +1 more source

Calponin‐3 is associated with epilepsy through the regulation of astrocyte activity

Brain Pathology, EarlyView.
Increased calponin‐3 expression correlates with astrocyte activation in epileptic mice, modulating adenosine metabolism regulators ADK and ENT1. Calponin‐3 overexpression increased susceptibility to epileptic seizures, while its downregulation reduces spontaneous recurrent seizures, identifying it as a potential therapeutic target for epilepsy ...
Lu Chen, Fei Yang, Wen‐Qian Yang, Ke Wang, Meng‐Shi Yang, Cheng Gou, Yan‐Ying Yu, Li‐Ling Chen, Ting‐Wan Xu, Dan Wang, Qian Wu, Qi‐Xin Zhou, Yan‐Bing Han   +12 more
wiley   +1 more source

Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms. [PDF]

Int J Mol Sci
Saldaña R, Carrascosa AJ, Torregrosa AB, Navarrete F, García-Gutiérrez MS, Manzanares J.   +5 more
europepmc   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Individual trajectories for recovery of neocortical activity in disorders of consciousness. [PDF]

PLoS Comput Biol
Tewarie PKB, Abeysuriya R, Panda R, Nùñez P, Vitello MM, van der Lande G, Gosseries O, Thibaut A, Laureys S, Deco G, Annen J.   +10 more
europepmc   +1 more source

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source