Results 211 to 220 of about 602,951 (277)

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

Advanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan, Erdi Zhang, Yuwen Ma, Zirui Meng, Sisi Li, Yimeng Ren, Xiaohe Tian, Yangyi He, Giuseppe Battaglia, Dong Zhou, Yun Liao, Binwu Ying, Jinmei Li, Minjin Wang   +13 more
wiley   +1 more source

Solution‐Processed Multi‐Junction Optoelectronic Synapses for Mode‐Switchable SWIR Neuromorphic Vision Sensing

Advanced Science, EarlyView.
A novel bias‐programmable shortwave infrared (SWIR) vision sensor is developed using multi‐junction colloidal quantum dots (QDs). Under varying applied voltage, the back‐to‐back rectifying junctions effectively tune trapping centers to switch the device between high‐speed photodetector and persistent synapse modes.
Zhuoyang He, Dae Yang Oh, Yi Ji, Yanyan Li, Chengwei Shan, Soong Ju Oh, Tianshuo Zhao   +6 more
wiley   +1 more source

Activity-dependent expression of Fezf2 regulates inhibitory synapse formation in pyramidal cells

Kroon T, Sanalidou S, Maeso P, Garces T, Yang H, Rico B.   +5 more
europepmc   +1 more source

Molecular and Cellular Mechanisms of Synaptogenesis and Synaptic Refinement During Cerebellar Circuit Formation. [PDF]

Int J Mol Sci
Ghiyamihoor F, Asemi Rad A, Marzban H.
europepmc   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Aberrant excitatory neuronal ERBB4 promotes Alzheimer's disease pathology. [PDF]

Nature
Lee SY, Park E, Lee HE, Kim S, Yeo Y, Park J, Choi YJ, Lee K, Yoon KJ, Park S, Kim E, Kim JI, Chung WS.   +12 more
europepmc   +1 more source

SIRT7‐Mediated H2BK120 Succinylation Drives Aberrant Mitophagy in Sepsis‐Associated Cognitive Dysfunction

Advanced Science, EarlyView.
Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng, Jiateng Zhou, Xiaoyu Guo, Ting Hong, Xuelian Li, Xingyu Wei, Chanhua Zhang, Xixue Zhang, Songbin Liu, Yulin Zhang, Liangfang Yao, Lina Huang, Weidong Gu   +12 more
wiley   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source

Sequential Regulation of Neurovascular Bone Regeneration in Large Bone Defects Using Black Phosphorus‐Europium Nanosheet Integrated TPMS Biomimetic Scaffold with Photo‐Controlled Ion Release

Advanced Science, EarlyView.
TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang, Yuping Zhang, Xiaoning Su, Ning Liu, Hui Zeng, Bo Yang, Yang Xue, Fang Guo, Changkui Liu   +8 more
wiley   +1 more source

Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies

Advanced Science, EarlyView.
Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee, Jihyang Park, Xinyi Wang, Yueqi Deng, Jiashu Ren, Tao Zhou   +5 more
wiley   +1 more source