Results 111 to 120 of about 3,617,097 (279)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Predicting business/ICT alignment with AntMiner+. [PDF]

open access: yes
In this paper we report on the results of a European survey on business/ICT alignment practices. The goal of this study is to come up with some practical guidelines for managers on how to strive for better alignment of ICT investments with business ...
Haesen, Raf   +7 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Alignment

open access: yes, 2013
Following 454 sequencing of the 16s rDNA region of bacterial communities of 59 samples of attine ants, 35,063 unique sequences were identified after data quality check.
Lars H. Hansen (129876)   +3 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

In-Flight Alignment Using H∞ Filter for Strapdown INS on Aircraft

open access: yesThe Scientific World Journal, 2014
In-flight alignment is an effective way to improve the accuracy and speed of initial alignment for strapdown inertial navigation system (INS). During the aircraft flight, strapdown INS alignment was disturbed by lineal and angular movements of the ...
Fu-Jun Pei, Xuan Liu, Li Zhu
doaj   +1 more source

Results of the Ontology Alignment Evaluation Initiative 2024

open access: yesCEUR Workshop Proceedings
The Ontology Alignment Evaluation Initiative (OAEI) aims at comparing ontology matching systems on precisely defined test cases. These test cases can be based on ontologies of different levels of complexity and use different evaluation modalities. The OAEI 2024 campaign offered 13 tracks and was attended by 13 participants.
Pour, Mina Abd Nikooie   +33 more
openaire   +7 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

In-Motion Forward–Forward Backtracking Fine Alignment Based on Displacement Observation for SINS/GNSS

open access: yesSensors
To solve the problem of slow convergence seen in the traditional fine alignment algorithm based on linear Kalman filtering, a forward–forward backtracking fine alignment algorithm for SINS is proposed after reanalyzing the fine alignment model in this ...
Yongyun Zhu   +4 more
doaj   +1 more source

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