Results 141 to 150 of about 3,405,157 (289)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

First Detection of CO Isotopologues in a High-redshift Main-sequence Galaxy: Evidence of a Top-heavy Stellar Initial Mass Function

The Astrophysical Journal
Recent observations and theories have presented a strong challenge to the universality of the stellar initial mass function (IMF) in extreme environments. A notable example has been found for starburst conditions, where evidence favors a top-heavy IMF, i.
Ziyi Guo, Zhi-Yu Zhang, Zhiqiang Yan, Eda Gjergo, Allison W. S. Man, R. J. Ivison, Xiaoting Fu, Yong Shi   +7 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Resolving the Mechanical and Radiative Feedback in J1044+0353 with Keck Cosmic Web Imager Spectral Mapping

The Astrophysical Journal
We present integral field spectroscopy toward and around J1044+0353, a rapidly growing, low-metallicity galaxy that produces extreme [O iii ] line emission.
Crystal L. Martin, Zixuan Peng, Yuan Li
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

The Panchromatic Hubble Andromeda Treasury: Triangulum Extended Region (PHATTER). VI. The High-mass Stellar Initial Mass Function of M33

The Astronomical Journal
We measure the high-mass stellar initial mass function (IMF) from resolved stars in M33 young stellar clusters. Leveraging the Hubble Space Telescope’s high resolving power, we fully model the IMF probabilistically.
Tobin M. Wainer, Benjamin F. Williams, L. Clifton Johnson, Daniel R. Weisz, Julianne J. Dalcanton, Anil C. Seth, Andrew Dolphin, Meredith J. Durbin, Eric F. Bell, Zhuo Chen, Puragra Guhathakurta, Eric W. Koch, Christina W. Lindberg, Erik Rosolowsky, Karin M. Sandstrom, Evan D. Skillman, Adam Smercina, Estephani E. TorresVillanueva   +17 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Experimental research on low and strength characteristics of coal slime based cemented filling material

Meitan kexue jishu
To study the flow and strength characteristics of coal slime based backfill materials, orthogonal tests were used to design one cemented backfill material combining coal slime, high-water-content materials, cement, and fly ash.
Baifu AN, Qiaomei YI, Xiang ZHAO, Weijian YU, Dongda WANG, Jiale WANG   +5 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source