Results 81 to 90 of about 3,387,094 (327)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

The Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

The Stellar Initial Mass Function

, 1999
The current status of both the observational evidence and the theory of the stellar initial mass function (IMF) is reviewed, with particular attention to the two basic, apparently universal features shown by all observations of nearby stellar systems: (1) a characteristic stellar mass of the order of one solar mass, and (2) a power-law decline of the ...
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Origin and Universality of the Stellar Initial Mass Function

, 2014
We review current theories for the origin of the Stellar Initial Mass Function (IMF) with particular focus on the extent to which the IMF can be considered universal across various environments.
Bastian, Nathan, Bate, Matthew R., Clark, Paul C., Hennebelle, Patrick, Hopkins, Philip F., Moraux, Estelle, Offner, Stella S. R., Whitworth, Anthony P.   +7 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The Initial Mass Function of GMCs

, 2004
The properties of GMCs in several Local Group galaxies are quantified and compared. It is found that the mass spectrum of GMCs varies from galaxy to galaxy. The variations are significant and do not appear to be the result of systematic uncertainties.
Blitz, Leo, Rosolowsky, Erik
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Early Enrichment Population Theory at High Redshift

The Astrophysical Journal
An early enrichment population (EEP) has been theorized to produce the observed intracluster medium (ICM) metallicity of galaxy clusters. This population likely existed at high redshifts ( z  ∼ 10), relics of which we posit exist today as dwarf galaxies.
Anne E. Blackwell, Joel N. Bregman
doaj   +1 more source

On the Mass Distribution of Stellar-Mass Black Holes

Open Astronomy, 2014
The observational stellar-mass black hole mass distribution exhibits a maximum at about 8 M⊙. It can be explained via the details of the massive star evolution, supernova explosions, or consequent black hole evolution.
Malkov O. Yu.
doaj   +1 more source