Results 81 to 90 of about 3,405,157 (289)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Earliest Stage of Galactic Star Formation
The Astrophysical Journal Letters, 2023 Using a recently developed technique to estimate gas temperatures ( T _SF ) in star-forming regions from large photometric surveys, we propose a diagram, analogous to the Hertzsprung–Russell diagram for individual stars, to probe the evolution of ...
Charles L. Steinhardt +7 more
doaj +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
The Initial Mass Function of the Galactic Early-type Field Stars Based on the LAMOST Survey
The Astrophysical JournalResearch on the high-mass end of the initial mass function (IMF) has been limited due to a scarcity of samples. Recently, Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST), as the most efficient spectroscopic telescope, has provided new ...
Qida Li +6 more
doaj +1 more source
The Stellar Initial Mass Function
, 1999 The current status of both the observational evidence and the theory of the stellar initial mass function (IMF) is reviewed, with particular attention to the two basic, apparently universal features shown by all observations of nearby stellar systems: (1) a characteristic stellar mass of the order of one solar mass, and (2) a power-law decline of the ...
openaire +2 more sources
Initial mass function of planetesimals formed by the streaming instability
, 2016 The streaming instability is a mechanism to concentrate solid particles into overdense filaments that undergo gravitational collapse and form planetesimals.
Johansen, Anders +2 more
core +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The Astrophysical JournalThe most metal-poor stars record the earliest metal enrichment triggered by Population III stars. By comparing observed abundance patterns with theoretical yields of metal-free stars, physical properties of their first star progenitors can be inferred ...
Ruizheng Jiang +3 more
doaj +1 more source
The Formation of Low-Mass Cluster Galaxies and the Universal Initial Galaxy Mass Function
, 2002 Clusters of galaxies have an observed over-density of low-luminosity systems in comparison to the field, although it is not yet agreed whether this effect is the result of initial galaxy mass functions that vary with environment or galaxy evolutionary ...
Adami C. +3 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source