Results 81 to 90 of about 1,934,975 (307)

Simulating the Collapse of Rotating Primordial Gas Clouds to Study the Possibility of the Survival of Population III Protostars

The Astrophysical Journal, 2023
It has been argued that the low-mass primordial stars ( m _Pop III ≤ 0.8 M _⊙ ) are likely to enter the main sequence and hence may possibly be found in present-day galaxies.
Shubham P. Raghuvanshi, Jayanta Dutta
doaj   +1 more source

A Universal Stellar Initial Mass Function? A critical look at variations in extreme environments [PDF]

, 2010
Whether the stellar initial mass function (IMF) is universal or is instead sensitive to environmental conditions is of critical importance: The IMF influences most observable properties of stellar populations and thus galaxies, and detecting variations ...
N. Bastian, K. Covey, Michael R. Meyer IoA, Cambridge, Cornell, Harvard-Smithsonian Cfa, E. Zurich, S. Observatory   +7 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Intense Star Cluster Formation: Stellar Masses, the Mass Function, and the Fundamental Mass Scale

The Astrophysical Journal Letters
Within the birth environment of a massive globular cluster, the combination of a luminous young stellar population and a high column density induces a state in which the thermal optical depth and radiation pressure are both appreciable.
Christopher D. Matzner
doaj   +1 more source

Massive stars reveal variations of the stellar initial mass function in the Milky Way stellar clusters [PDF]

, 2016
We investigate whether the stellar initial mass function (IMF) is universal, or whether it varies significantly among young stellar clusters in the Milky Way. We propose a method to uncover the range of variation of the parameters that describe the shape
S. Dib, S. Schmeja, S. Hony
semanticscholar   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The bimodal initial mass function in the Orion Nebula Cloud [PDF]

, 2016
Due to its youth, proximity and richness the Orion Nebula Cloud (ONC) is an ideal testbed to obtain a comprehensive view on the Initial Mass Function (IMF) down to the planetary mass regime.
H. Drass, M. Haas, R. Chini, A. Bayo, M. Hackstein, V. Hoffmeister, N. Godoy, N. Vogt   +7 more
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

The Gaia-ESO Survey: membership and initial mass function of the γ Velorum cluster [PDF]

, 2016
Context. Understanding the properties of young open clusters, such as the Initial Mass Function (IMF), star formation history and dynamic evolution, is crucial to obtain reliable theoretical predictions of the mechanisms involved in the star formation ...
L. Prisinzano, F. Damiani, G. Micela, R. Jeffries, E. Franciosini, G. Sacco, A. Frasca, A. Klutsch, A. Lanzafame, E. Alfaro, K. Biazzo, R. Bonito, A. Bragaglia, M. Caramazza, A. Vallenari, G. Carraro, M. T. Costado, E. Flaccomio, P. Jofré, C. Lardo, L. Monaco, L. Morbidelli, N. Mowlavi, E. Pancino, S. Randich, S. Zaggia   +25 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source