Results 241 to 250 of about 167,568,926 (302)

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

Replication origin flexibility: a tool to mitigate the hazards of excess replication. [PDF]

Trends Genet
Fu H, Redon CE, Brenner HM, Ack MR, Aladjem MI.   +4 more
europepmc   +1 more source

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

SMC ensures efficient chromosome replication and oriC positioning during Streptomyces spore germination. [PDF]

Sci Rep
Pawlikiewicz K, Strzałka A, Nurek A, Donczew M, Gierlikowska A, Gongerowska-Jac M, Szafran MJ, Jakimowicz D.   +7 more
europepmc   +1 more source

L‐Cysteine and N‐Acetylcysteine Supplementation Improves Clinical Outcome in a Patient With COXPD10

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT MTO1 is a nuclear gene that encodes a mitochondrial protein essential for modifying mitochondrial transfer RNAs (tRNAs) and stabilizing codon‐anticodon interactions to ensure accurate and efficient mitochondrial protein synthesis and oxidative phosphorylation.
Nishitha R. Pillai, Sara A. Elsbecker, Grace Bronken McCarthy, Kaitlin Weisshappel, Peter Karachunski, Fernando Scaglia   +5 more
wiley   +1 more source

Replication origin firing capacity indicates ATR inhibitor sensitivity. [PDF]

Nat Commun
Lumeau A, Pfuderer PL, Scarth JA, Maniati E, Guscott MA, Shaikh N, Copley FB, Gerdes H, De Angelis S, Alard EL, Wang J, Cutillas PR, Mardakheh FK, Boemo MA, Forment JV, McClelland SE.   +15 more
europepmc   +1 more source

Domain dynamics within the PriA DNA helicase regulate DNA replication restart. [PDF]

Nucleic Acids Res
Deorio HR, Duckworth AT, Forsythe GR, Sung AY, Sandler SJ, Grant T, Keck JL.   +6 more
europepmc   +1 more source

The iron-sulfur accelerator YgfZ modulates genome-wide IHF-binding dynamics to regulate replication initiation in <i>Escherichia coli</i>. [PDF]

Front Microbiol
Kasho K, Satomura R, Yoshida M, Murofushi R, Kitamura I, Nakagawa S, Nakagaki W, Katayama T.   +7 more
europepmc   +1 more source

Twisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance. [PDF]

Aging Cell
Wang J, Su Y, Chen C, Li Y, Han J, Du L, Zheng L, Dang YL, Peng Y.   +8 more
europepmc   +1 more source