Results 261 to 270 of about 167,568,926 (302)
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Initiation of DNA replication in yeast chromosomes
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1987Abstract A family of DNA fragments from the yeast genome has properties that suggest that chromosome replication starts at specific DNA sequences. These elements (autonomously replicating sequences: ARS) have a bipartite structure: a small (less than 20 base pairs) AT-rich region essential for function, flanked by larger regions ...
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Analysis of the temporal program of replication initiation in yeast chromosomes
Journal of Cell Science, 1995ABSTRACT The multiple origins of eukaryotic chromosomes vary in the time of their initiation during S phase. In the chromosomes of Saccharomyces cerevisiae the presence of a functional telomere causes nearby origins to delay initiation until the second half of S phase. The key feature of telomeres that causes the replication delay is the
K L, Friedman +3 more
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Initiation at Closely Spaced Replication Origins in a Yeast Chromosome
Science, 1993Replication of eukaryotic chromosomes involves initiation at origins spaced an average of 50 to 100 kilobase pairs. In yeast, potential origins can be recognized as autonomous replication sequences (ARSs) that allow maintenance of plasmids. However, there are more ARS elements than active chromosomal origins.
B J, Brewer, W L, Fangman
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Initiation of DNA replication in eukaryotic chromosomes
Trends in Biochemical Sciences, 1981Abstract The large amount of DNA in eukaryotic chromosomes is duplicated exactly for distribution to daughter cells at division. Unlike prokaryotes, the eukaryote must co-ordinate multiple initiations of replication on a single molecule so as to replicate the DNA once, and only once, in a cell cycle.
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Regulation of Initiation ofBacillus subtilisChromosome Replication
Plasmid, 1999Bacterial chromosome replication is tightly regulated at the initiation stage to coordinate with mass increase. Together with chromosome partition at cell division, this regulation mechanism ensures the proper number of chromosomes in daughter cells at any growth rate.
S, Moriya +3 more
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Regulation of Initiation of Chromosome Replication
1992In opening this Symposium, I thought it appropriate to reflect on some broad issues of research on DNA replication before presenting a brief review of our E. coli work on the start and elongation of chains and on the initiation and termination of chromosomes.
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SCIENTIA SINICA Vitae, 2013
In eukaryotes, DNA replication initiates at multiple and specific sites on chromosomal DNA. When cells are in late M and G1 phases, Cdc6/Cdc18, Cdt1 and MCM are loaded to ORC binding sites on DNA replication origins to form pre-RC (pre-replication complex). Pre-RC is activated at the transition of G1 to S phase. Subsequently, those proteins that act at
LiHong WU, DaoChun Kong, Yang LIU
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In eukaryotes, DNA replication initiates at multiple and specific sites on chromosomal DNA. When cells are in late M and G1 phases, Cdc6/Cdc18, Cdt1 and MCM are loaded to ORC binding sites on DNA replication origins to form pre-RC (pre-replication complex). Pre-RC is activated at the transition of G1 to S phase. Subsequently, those proteins that act at
LiHong WU, DaoChun Kong, Yang LIU
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A new mutant of Bacillus subtilis altered in the initiation of chromosome replication
Molecular and General Genetics MGG, 1975We have isolated a new mutant of Bacillus subtilis temperature sensitive in DNA replication; its properties are those of an initiation mutant. When liquid cultures are shifted to 48 degrees DNA replication is the first macromolecular synthesis that stops, but only after synthesis of the amount of DNA predicted for the completion of one replication ...
S. RIVA +6 more
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Coupling the initiation of chromosome replication to cell size in Escherichia coli
Current Opinion in Microbiology, 2003Bacterial cells change size dramatically with change in growth rate, but the ratio between cell volume and the number of copies of the origin of chromosome replication (oriC) is roughly constant at the time of initiation of DNA replication at almost all growth rates.
William D, Donachie, Garry W, Blakely
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Initiation of DNA replication in chromosomes of Chinese hamster ovary cells
Chromosoma, 1979The initiation of DNA replication and the subsequent chain elongation were studied using Chinese hamster ovary cells synchronized at the beginning of S phase. The cells were synchronized by a combination of mitotic selection and treatment with 5-fluorodeoxyuridine (FdU).
T J, Laughlin, J H, Taylor
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