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Studies on the regulation of initiation of chromosome replication in Escherichia coli
Journal of Molecular Biology, 1978Abstract The total initiation frequency of chromosome replication in Escherichia coli is dependent on two factors; the timing or time interval between successive initiations on an individual chromosome (initiation pace) and the number of individual chromosomes which are being replicated per cell.
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Does the Initiation of Chromosome Replication Regulate Cell Division?
1977Publisher Summary The chapter discusses whether size of cells engaged in initiation of DNA replication has smaller variance than the size of cells in the act of cytoplasmic division, and whether the time intervals among various stages of the cell cycle are distributed with large or small variance for cells within a balanced growing population.
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Initiation of replication in mammalian chromosomes.
Critical reviews in eukaryotic gene expression, 1993Mammalian origins of replication are scattered at about 100-kb intervals along each chromosomal DNA fiber. It is not known whether origins are genetically defined sequences analogous to those that control initiation of replication in microorganisms. Since the advent of recombinant DNA techniques, it has become possible to search for origins in defined ...
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Initiation of the Streptomyces chromosome replication
Antonie van Leeuwenhoek, 2000J, Zakrzewska-Czerwińska +4 more
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Regulatory Network of the Initiation of Chromosomal Replication inEscherichia coli
Critical Reviews in Biochemistry and Molecular Biology, 2005The bacterial chromosome is replicated once during the division cycle, a process ensured by the tight regulation of initiation at oriC. In prokaryotes, the initiator protein DnaA plays an essential role at the initiation step, and feedback control is critical in regulating initiation.
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Speculations on the initiation of chromosome replication in Escherichia coli: The dualism hypothesis
Medical Hypotheses, 2011The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be highly structured.
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Proceedings of the National Academy of Sciences of the United States of America, 2023
Johan Elf, Oscar Broström, David Fange
exaly
Johan Elf, Oscar Broström, David Fange
exaly
Initiation of DNA Replication at the Chromosomal Origin of E. coli, oriC
2017The Escherichia coli chromosomal origin consists of a duplex-unwinding region and a region bearing a DNA-bending protein, IHF-binding site, and clusters of binding sites for the initiator protein DnaA. ATP-DnaA molecules form highly organized oligomers in a process stimulated by DiaA, a DnaA-binding protein.
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