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Regulation of Initiation of Chromosome Replication
1992In opening this Symposium, I thought it appropriate to reflect on some broad issues of research on DNA replication before presenting a brief review of our E. coli work on the start and elongation of chains and on the initiation and termination of chromosomes.
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SCIENTIA SINICA Vitae, 2013
In eukaryotes, DNA replication initiates at multiple and specific sites on chromosomal DNA. When cells are in late M and G1 phases, Cdc6/Cdc18, Cdt1 and MCM are loaded to ORC binding sites on DNA replication origins to form pre-RC (pre-replication complex). Pre-RC is activated at the transition of G1 to S phase. Subsequently, those proteins that act at
LiHong WU, DaoChun Kong, Yang LIU
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In eukaryotes, DNA replication initiates at multiple and specific sites on chromosomal DNA. When cells are in late M and G1 phases, Cdc6/Cdc18, Cdt1 and MCM are loaded to ORC binding sites on DNA replication origins to form pre-RC (pre-replication complex). Pre-RC is activated at the transition of G1 to S phase. Subsequently, those proteins that act at
LiHong WU, DaoChun Kong, Yang LIU
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The initiation of chromosome replication in a dnaAts46 and a dnaA + strain at various temperatures
Molecular and General Genetics MGG, 1981The regulation of chromosome replication initiation was studied at various temperatures with an E. coli dnaA46 strain and its dnaA+ parent. We find that, in both strains, the "initiation mass" varies depending upon growth temperature while the replication time remains constant relative to the cell doubling time. In the permissive temperature range, the
J, Frey, M, Chandler, L, Caro
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Studies on the regulation of initiation of chromosome replication in Escherichia coli
Journal of Molecular Biology, 1978Abstract The total initiation frequency of chromosome replication in Escherichia coli is dependent on two factors; the timing or time interval between successive initiations on an individual chromosome (initiation pace) and the number of individual chromosomes which are being replicated per cell.
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Initiation of DNA replication in chromosomes of Chinese hamster ovary cells
Chromosoma, 1979The initiation of DNA replication and the subsequent chain elongation were studied using Chinese hamster ovary cells synchronized at the beginning of S phase. The cells were synchronized by a combination of mitotic selection and treatment with 5-fluorodeoxyuridine (FdU).
T J, Laughlin, J H, Taylor
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Does the Initiation of Chromosome Replication Regulate Cell Division?
1977Publisher Summary The chapter discusses whether size of cells engaged in initiation of DNA replication has smaller variance than the size of cells in the act of cytoplasmic division, and whether the time intervals among various stages of the cell cycle are distributed with large or small variance for cells within a balanced growing population.
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Initiation of replication in mammalian chromosomes.
Critical reviews in eukaryotic gene expression, 1993Mammalian origins of replication are scattered at about 100-kb intervals along each chromosomal DNA fiber. It is not known whether origins are genetically defined sequences analogous to those that control initiation of replication in microorganisms. Since the advent of recombinant DNA techniques, it has become possible to search for origins in defined ...
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Initiation of the Streptomyces chromosome replication
Antonie van Leeuwenhoek, 2000J, Zakrzewska-CzerwiĆska +4 more
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Speculations on the initiation of chromosome replication in Escherichia coli: The dualism hypothesis
Medical Hypotheses, 2011The exact nature of the mechanism that triggers initiation of chromosome replication in the best understood of all organisms, Escherichia coli, remains mysterious. Here, I suggest that this mechanism evolved in response to the problems that arise if chromosome replication does not occur. E. coli is now known to be highly structured.
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