Results 81 to 90 of about 167,568,926 (302)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Molecular Architecture of the DNA Replication Origin Activation Checkpoint [PDF]

, 2010
Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication initiation and dissect this checkpoint in fibroblasts.
Claire Mulvey, Slavica Tudzarova, Kai Stoeber, Tudzarova, S, Mulvey, C, Godovac-Zimmermann, J, Wollenschlager, A, Jasminka Godovac-Zimmermann, Matthew W B Trotter, Alex Wollenschlaeger, Stoeber, K, Gareth H Williams, Trotter, MWB, Williams, G   +13 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

USF binding sequences from the HS4 insulator element impose early replication timing on a vertebrate replicator [PDF]

, 2012
The nuclear genomes of vertebrates show a highly organized program of DNA replication where GC-rich isochores are replicated early in S-phase, while AT-rich isochores are late replicating.
Chilaka, S., Nicole Boggetto (179283), Meiji Kit-Wan Ma, Jean-Charles Cadoret (179279), Marie-Noëlle Prioleau (179285), Nicole Boggetto, Sabarinadh Chilaka, Jean-Charles Cadoret, Adam G West, Sabarinadh Chilaka (179276), Marie-Noëlle Prioleau, Vahideh Hassan-Zadeh, West, A. G., Adam G. West (116083), Hassan-Zadeh, V., Ma, M., Prioleau, M-N., Vahideh Hassan-Zadeh (179272), Boggetto, N., Meiji Kit-Wan Ma (179282), Cadoret, J-C.   +20 more
core   +2 more sources

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

The dynamics of genome replication using deep sequencing [PDF]

, 2014
Peer ...
Blythe, Martin J., Nieduszynski, Conrad A, de Moura, Alessandro P. S., Nakato, Ryuichiro, Shirahige, Katsuhiko, de Moura, Alessandro P S, Malla, Sunir, Nieduszynski, Conrad A., Hawkins, Michelle, Müller, Carolin A, M�ller, Carolin A., Müller, Carolin A., de Moura, Alessandro P.S., Retkute, Renata, Wilson, Ray, Komata, Makiko, Blythe, Martin J   +16 more
core   +1 more source

The DnaA Tale

Frontiers in Microbiology, 2018
More than 50 years have passed since the presentation of the Replicon Model which states that a positively acting initiator interacts with a specific site on a circular chromosome molecule to initiate DNA replication. Since then, the origin of chromosome
Flemming G. Hansen, Tove Atlung
doaj   +1 more source

Fragile site instability in Saccharomyces cerevisiae causes loss of heterozygosity by mitotic crossovers and break-induced replication. [PDF]

PLoS Genetics, 2013
Loss of heterozygosity (LOH) at tumor suppressor loci is a major contributor to cancer initiation and progression. Both deletions and mitotic recombination can lead to LOH.
Danielle M Rosen, Ellen M Younkin, Shaylynn D Miller, Anne M Casper   +3 more
doaj   +1 more source

Initiation of chromosome replication in bacteria: analysis of an inhibitor control model [PDF]

Journal of Bacteriology, 1987
This article contains an analysis of a version of the well-known inhibitor-dilution model for the control of initiation of chromosome replication in bacteria. According to this model, an unstable inhibitor interacts with an initiation primer in a hit-and-destroy fashion to prevent successful initiation; both constituents are presumed to be RNA species ...
H, Margalit, N B, Grover
openaire   +2 more sources

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source