Results 91 to 100 of about 26,569 (289)

The characteristics of collagen‐induced rheumatoid arthritis in macaques and the changes of heart

Animal Models and Experimental Medicine, EarlyView.
The disease progression in CIA macaques was categorized into three stages: IIR (days 14–34): The indicators related to rheumatoid arthritis and the levels of immunoglobulin were all elevated. There was a small amount of joint effusion, edema and mild synovial hyperplasia. No joint swelling was observed by naked eye.
Lei Zhang, Haifeng Jiang, Zhen Xu, Tingyu Dong, Xiaoyi Liu, Shangxue Yan, Jiajie Kuai, Yan Chang, Wei Wei   +8 more
wiley   +1 more source

Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression [PDF]

, 2015
This work was supported by grant from DEBRA Australia to AJC and ZK. AJC is supported by the NHMRC Senior Research Fellowship (#1002009). ZK is supported by the NHMRC Early Career Fellowship (#1036509)
Alexander, Arkell, Asch, Bokarewa, Buccione, Campbell, Campbell, Campbell, Cao, Chen, Chen, Choi, Condeelis, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Cowin, Gettemans, He, Janmey, Jeong, Jeong, Kavallaris, Kayani, Leigh, Matthaei, McCulloch, McCulloch, Murray, Murray, Nishimura, Nishimura, O'Toole, Olson, Ryo, Samuel, South, Stallcup, Stallcup, Tombes, Tong, Turki, Uppaluri, Watt, Watt, Yuan   +53 more
core   +2 more sources

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, EarlyView.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis [PDF]

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK ...
Alcami, Antonio, Antoniou, Maria, Begoña Ruiz-Argüello, Maria, Blackwell, Jenefer M., Carson, Connor, Christodoulou, Vasiliki, Courtenay, Orin, Messaritakis, Ippokratis   +7 more
core   +1 more source

Sentinel lymph node in early stage ovarian cancer; a literature review [PDF]

, 2018
Although sentinel lymph node mapping has been widely implemented in gynecological malignancies in order to minimize the number of unnecessary lymph node dissections and to diminish postoperative morbidity rate, little is known about ovarian cancer ...
Bacalbasa, Nicolae, Balescu, Irina, Brasoveanu, Vladislav, Brezean, Iulian, Vilcu, Mihaela   +4 more
core   +3 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Programa quinquenal de eliminación de la rabia humana en una provincia con rabia canina endémica en Tailandia

Bulletin of the World Health Organization
A five-year project to prevent human deaths from rabies in Phetchabun Province, Thailand involved increasing accessibility of post-exposure treatment with the Thai Red Cross intradermal (2-2-2-0-1-1) regimen for humans exposed to potentially and ...
T. Kamoltham, J. Singhsa, U. Promsaranee, P. Sonthon, P. Mathean, W. Thinyounyong   +5 more
doaj   +1 more source

Repeated intradermal lipopolysaccharide challenge responses in healthy volunteers: Implications for clinical pharmacology studies

British Journal of Clinical Pharmacology, EarlyView.
Aim Intradermal application of lipopolysaccharide (LPS), a Toll‐like receptor 4 agonist, induces a local inflammatory response and is used as a human challenge model to evaluate the pharmacodynamics of investigational medicinal products. While currently applied in a single, parallel‐group setting, alternative within‐subject designs involving repeated ...
Alexandra A. J. Sillé, Juliette A. van den Noort, Iva Lelios, Diana R. Pereira, Marzia A. Scelsi, Erica S. Klaassen, Philipp Schoenenberger, Naomi B. Klarenbeek, Pierre‐Eric Juif, Pascal Espie, Manon A. A. Jansen, Matthijs Moerland, Richard W. D. Welford   +12 more
wiley   +1 more source

Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

Revista do Instituto de Medicina Tropical de São Paulo, 1989
Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost.
Flair José Carrilho, Maria Lúcia Queiroz, Luiz Caetano da Silva, Luís Edmundo Pinto da Fonseca, Celso Granato, Isabel Oba, Leda Obara   +6 more
doaj   +1 more source

Prolonged intralymphatic delivery of dendritic cells through implantable lymphatic ports in patients with advanced cancer [PDF]

, 2016
Background: The currently-used modes of administration of immunotherapeutic agents result in their limited delivery to the lymph nodes and/or require repetitive ultrasound-guided nodal injections or microsurgical lymphatic injections, limiting their ...
Bartlett, DL, Butterfield, LH, Edington, HD, Kalinski, P, Pingpank, JF, Radomski, M, Whiteside, TL, Wieckowski, E, Zeh, HJ   +8 more
core   +3 more sources