Results 41 to 50 of about 163,246 (289)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Fasudil in Combination With Bone Marrow Stromal Cells (BMSCs) Attenuates Alzheimer\u27s Disease-Related Changes Through the Regulation of the Peripheral Immune System. [PDF]

, 2018
Alzheimer\u27s disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation.
Chai, Zhi, Chumber, Jasleen, Gao, Ye, Gu, Qingfang, Jiang, Yuqiang, Kumar, Gajendra, Liu, Chunyun, Ma, Cun-Gen, Xiao, Bao-Guo, Yan, Yuqing, Yu, Hongqiang, Yu, Jiezhong, Zhang, Guang-Xian, Zhang, Han-Ting, Zhao, Yijin   +14 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Can Human Recombinant Epidermal Growth Factor Improve Ischemia and Induce Healing of Anastomosis in an Experimental Study in a Rabbit Model?

Journal of Investigative Surgery, 2017
Purpose: Anastomotic leaks following intestinal operations may cause devastating effects on patients. Ischemia may also occur at the intestinal walls in the presence of strangulations.
Rahman Şenocak, Mustafa Tahir Özer, Şahin Kaymak, Zafer Kılbaş, Armağan Günal, Metin Uyanık, Orhan Kozak   +6 more
doaj   +1 more source

A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice

Journal of Lipid Research, 2010
Here, we report the creation of a single-helix peptide (ATI-5261) that stimulates cellular cholesterol efflux with Km molar efficiency approximating native apolipoproteins.
John K. Bielicki, Haiyan Zhang, Yuan Cortez, Ying Zheng, Vasanthy Narayanaswami, Arti Patel, Jan Johansson, Salman Azhar   +7 more
doaj   +1 more source

Genome analysis of a highly virulent serotype 1 strain of streptococcus pneumoniae from West Africa [PDF]

, 2012
Streptococcus pneumoniae is a leading cause of pneumonia, meningitis, and bacteremia, estimated to cause 2 million deaths annually. The majority of pneumococcal mortality occurs in developing countries, with serotype 1 a leading cause in these areas.
Chinelo Ebruke, Daniel M. Musher, George M. Weinstock, Mark J. Pallen, Martin Antonio, Nicholas J. Loman, Richard A. Adegbola, Stefan Bereswill, Tiffany M. Williams   +8 more
core   +6 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Repression of factor VIII inhibitor development with apoptotic factor VIII-expressing embryonic stem cells

Hematology Reports, 2013
Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to ...
Yoshihiko Sakurai, Shogo Kasuda, Kohei Tatsumi, Tomohiro Takeda, Junko Kato, Atsushi Kubo, Midori Shima   +6 more
doaj   +1 more source

Establishing a nonlethal and efficient mouse model of male gonadotoxicity by intraperitoneal busulfan injection

Asian Journal of Andrology, 2020
An ideal animal model of azoospermia would be a powerful tool for the evaluation of spermatogonial stem cell (SSC) transplantation. Busulfan has been commonly used to develop such a model, but 30%–87% of mice die when administered an intraperitoneal ...
Yun Xie, Cun-Can Deng, Bin Ouyang, Lin-Yan Lv, Jia-Hui Yao, Chi Zhang, Hai-Cheng Chen, Xiao-Yan Li, Xiang-Zhou Sun, Chun-Hua Deng, Gui-Hua Liu   +10 more
doaj   +1 more source

Local Delivery of CTLA-4 Blockade Inhibits Growth of Pancreatic Tumors [PDF]

, 2016
Immune checkpoint blockade has demonstrated great potential in activating antitumor immunity. Ipilimumab is a monoclonal antibody which targets cytotoxic T-lymphocyte antigen-4. CTLA-4 belongs to the CD28 class of receptors and is found on the surface of
Baltz, Jack
core   +2 more sources