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Haunting innate immune memories of COVID-19
Cell, 2023In addition to acute hyperinflammatory responses, SARS-CoV-2 infections can have long-term effects on our immune system leading to, for example, post-acute sequelae of COVID-19 (PASC). In this issue of Cell, Cheong et al. show that severe infections via IL-6 induce persistent epigenetic signatures in hemopoietic stem cells and their myeloid progenitors
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The involvement of TREM2 in innate immune memory
2023Innate immune memory is a biological phenomenon in which immune cells begin to reshape when the innate immune system responds to immune stimuli. After the initial immune response to an environmental stimulus, cells undergo epigenetic reprogramming to alter the subsequent immune response, either enhancing or suppressing the subsequent inflammatory ...
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Evolution and development of innate immune memory
Science ImmunologyInnate immune memory (trained immunity) is mediated by epigenetic and metabolic reprogramming of innate immune cells and hematopoietic progenitors, enabling altered responses to subsequent challenges. Mechanistically conserved across eukaryotes, trained immunity in mammals operates as a dynamically regulated, life-phase–specific system. The demands and
Maziar Divangahi, Eva Kaufmann
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Induction of transgenerational innate immune memory against infections in a brine shrimp () model
Aquaculture, 2022Daisy Vanrompay +2 more
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Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host’s Response to Pathogens
Cell Host and Microbe, 2019Leo A.B. Joosten +2 more
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