Results 11 to 20 of about 732,201 (216)
The innate immune response in tauopathies
European Journal of Immunology, 2023 Abstract Tauopathies, which include frontotemporal dementia, Alzheimer's disease, and chronic traumatic encephalopathy, are a class of neurological disorders resulting from pathogenic tau aggregates. These aggregates disrupt neuronal health and function leading to the cognitive and physical decline of tauopathy patients.
Alexis M. Johnson, John R. Lukens
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Innate Immune Responses in Leprosy [PDF]
Frontiers in Immunology, 2018 Leprosy is an infectious disease that may present different clinical forms depending on host immune response to Mycobacterium leprae. Several studies have clarified the role of various T cell populations in leprosy; however, recent evidences suggest that local innate immune mechanisms are key determinants in driving the disease to its different ...
Roberta Olmo Pinheiro +8 more
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Innate immune responses in pneumonia
Pneumonia, 2023 AbstractThe lungs are an immunologically unique environment; they are exposed to innumerable pathogens and particulate matter daily. Appropriate clearance of pathogens and response to pollutants is required to prevent overwhelming infection, while preventing tissue damage and maintaining efficient gas exchange.
Filiz T. Korkmaz, Katrina E. Traber
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Innate immune responses to trauma [PDF]
Nature Immunology, 2018 Trauma can affect any individual at any location and at any time over a lifespan. The disruption of macrobarriers and microbarriers induces instant activation of innate immunity. The subsequent complex response, designed to limit further damage and induce healing, also represents a major driver of complications and fatal outcome after injury.
Markus, Huber-Lang +2 more
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Signaling in the innate immune response [PDF]
WormBook, 2018 The nematode Caenorhabditis elegans relies on its innate immune defenses to counter infection. In this review, we focus on its response to infection by bacterial and fungal pathogens. We describe the different families of effector proteins that contribute to host defense, as well as the signal transduction pathways that regulate their expression.
Dennis H, Kim, Jonathan J, Ewbank
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Innate Immune Responses to AAV Vectors [PDF]
Frontiers in Microbiology, 2011 Gene replacement therapy by in vivo delivery of adeno-associated virus (AAV) is attractive as a potential treatment for a variety of genetic disorders. However, while AAV has been used successfully in many models, other experiments in clinical trials and in animal models have been hampered by undesired responses from the immune system.
Rogers, Geoffrey L. +5 more
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Innate Immune Responses to Tuberculosis
Microbiology Spectrum, 2016 ABSTRACTTuberculosis remains one of the greatest threats to human health. The causative bacterium,Mycobacterium tuberculosis, is acquired by the respiratory route. It is exquisitely adapted to humans and is a prototypic intracellular pathogen of macrophages, with alveolar macrophages being the primary conduit of infection and disease.
Jeffrey S, Schorey, Larry S, Schlesinger
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The innate immune response in leprosy [PDF]
Current Opinion in Immunology, 2010 Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell ...
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Is innate enough? The innate immune response in Drosophila
Comptes Rendus. Biologies, 2004 In recent years, the innate immune system has emerged from the shadow of adaptive immune responses as a major area of research in its own right. One of the most significant model systems that has been used to investigate this phenomenon has been the fruit fly, Drosophila melanogaster ...
Irving, Phil +2 more
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Natural Killer Cells in Paediatric Soft Tissue Sarcomas: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Paediatric soft tissue sarcomas (pSTS) are a rare and heterogeneous group of malignant tumours arising in tissues of mesenchymal origin. The role of natural killer (NK) cells in pSTS remains poorly understood, with evidence fragmented across small preclinical studies and early‐phase clinical trials.
Raya Dean +7 more
wiley +1 more source