Results 121 to 130 of about 728,146 (346)
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Sultan Qaboos University Medical Journal, 2015 There is increasing interest by physicians in the impact of the innate immune system on human diseases. In particular, the role of the molecules that initiate and amplify innate immune pathways, namely damage associated molecular patterns (DAMPs), is of ...
Walter G. Land
doaj +2 more sources
Current trends in single‐cell RNA sequencing applications in diabetes mellitus
FEBS Open Bio, EarlyView.Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian +6 more
wiley +1 more source
Targeting Melanoma via the Innate Immune System [PDF]
, 2012 Over-expression of the folate receptor (FR) has been shown on the vascular side of cancerous cells including those of the breast, ovaries, testes, and cervix. However, FR over-expression has not yet been explored fully in melanoma.
Skinner, Cassandra
core
Modelling the Innate Immune System
, 2012 The Human Immune System (HIS) is a complex network composed of specialized cells, tissues, and organs that is responsible for protecting the organism against diseases caused by distinct pathogenic agents, such as viruses, bacteria and other parasites.
Pedro Augusto F. Rocha +5 more
openaire +4 more sources
Trauma: the role of the innate immune system.
World journal of emergency surgery : WJES, 2006 Immune dysfunction can provoke (multiple) organ failure in severely injured patients. This dysfunction manifests in two forms, which follow a biphasic pattern. During the first phase, in addition to the injury by trauma, organ damage is caused by the immune system during a systemic inflammatory response.
Ger T. Rijkers +3 more
openaire +4 more sources
Earthing effects on mitochondrial function: ATP production and ROS generation
FEBS Open Bio, EarlyView.In contrast to sham and naive controls, grounded mitochondria not only exhibit significantly enhanced energy production but also demonstrate a remarkable reduction in membrane potential and oxidative stress. This suggests a profound improvement in mitochondrial health, presenting a promising avenue for therapeutic interventions.
Cecilia Giulivi, Richard Kotz
wiley +1 more source
Innate Immunity: The Virtues of a Nonclonal System of Recognition [PDF]
, 1997 Ruslan Medzhitov, Charles A. Janeway
openalex +1 more source
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Interactions between Innate Lymphoid Cells and Cells of the Innate and Adaptive Immune System
Frontiers in Immunology, 2017 Type 2 innate lymphoid cells (ILC2s) are a major source of cytokines, which are also produced by Th2 cells and several cell types of the innate immune system.
Cornelia Symowski, David Voehringer
doaj +1 more source