Results 111 to 120 of about 1,626,946 (340)
How Specific Should Immunological Memory Be? [PDF]
, 1999 Protection against infection hinges on a close interplay between the innate immune system and the adaptive immune system. Depending on the type and context of a pathogen, the innate system instructs the adaptive immune system to induce an appropriate ...
Boer, R.J. de +2 more
core +1 more source
Quantifying the relevance of different mediators in the human immune cell network
, 2004 Immune cells coordinate their efforts for the correct and efficient functioning of the immune system (IS). Each cell type plays a distinct role and communicates with other cell types through mediators such as cytokines, chemokines and hormones, among ...
Castellani, Gastone C. +6 more
core +1 more source
Innate immunity and neuroinflammation [PDF]
, 2013 Copyright © 2013 Abhishek Shastri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly ...
Bonifati, DM, Kishore, U, Shastri, A
core +3 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Innate-adaptive immunity interplay and redox regulation in immune response
Redox Biology, 2020 Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue inflammation. The innate immune system is the front line of host defense in which innate immune cells are activated by danger signals, including pathogen- and
Lizhe Sun +5 more
doaj +1 more source
Rational modulation of the innate immune system for neuroprotection in ischemic stroke
Frontiers in Neuroscience, 2015 The innate immune system plays a dualistic role in the evolution of ischemic brain damage and has also been implicated in ischemic tolerance produced by different conditioning stimuli.
D. Amantea +8 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Probing the phenomenon of trained immunity in invertebrates during a transgenerational study, using brine shrimp Artemia as a model system [PDF]
, 2016 The invertebrate’s innate immune system was reported to show some form of adaptive features, termed trained immunity. However, the memory characteristics of innate immune system and the mechanisms behind such phenomena remain unclear.
Biswas, P. +3 more
core
PPARγ and the Innate Immune System Mediate the Resolution of Inflammation
PPAR Research, 2015 The resolution of inflammation is an active and dynamic process, mediated in large part by the innate immune system. Resolution represents not only an increase in anti-inflammatory actions, but also a paradigm shift in immune cell function to restore ...
Amanda Croasdell +5 more
semanticscholar +1 more source
DNA sensors in innate immune system
Uirusu, 2008 Microbial sensing mediated by pattern recognition receptors (PRRs) is the first key step to trigger innate immune responses, represented by the induction of type I interferons (IFNs), proinflammatory cytokines and chemokines. This innate signaling elicits an efficient activation of more specific responses in adaptive immunity.
Akinori, Takaoka, Shigeki, Shinohara
openaire +3 more sources