Results 91 to 100 of about 1,626,946 (340)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Regulation of the innate immune response in rheumatoid arthritis

Frontiers in Immunology
Rheumatoid arthritis (RA) is a common inflammatory joint disorder characterized by progressive joint destruction, leading to painful deformity and limited mobility, for which there is currently no effective cure.
Aikeremujiang Muheremu, Aikeremujiang Muheremu, Shalayiding Aierxiding, Shalayiding Aierxiding, Jian Gao, Jian Gao   +5 more
doaj   +1 more source

lncRNAs Regulate Innate Immune Responses and Their Roles in Macrophage Polarization

Mediators of Inflammation, 2018
The innate immune system is the first line of defense against microbial pathogens. The activated innate immune system plays important roles in eliciting antimicrobial defenses.
Zhen Wang, Ying Zheng
doaj   +1 more source

Chronic helminth infection burden differentially affects haematopoietic cell development while ageing selectively impairs adaptive responses to infection [PDF]

, 2018
Throughout the lifespan of an individual, the immune system undergoes complex changes while facing novel and chronic infections. Helminths, which infect over one billion people and impose heavy livestock productivity losses, typically cause chronic ...
Babayan, Simon A., Duprez, Jessica S., Selman, Colin, Sinclair, Amy   +3 more
core   +1 more source

The Innate Immune System in Acute and Chronic Wounds

Advances in wound care, 2016
Significance: This review article provides an overview of the critical roles of the innate immune system to wound healing. It explores aspects of dysregulation of individual innate immune elements known to compromise wound repair and promote nonhealing ...
A. MacLeod, J. Mansbridge
semanticscholar   +1 more source

The Innate Immune System and Transplantation [PDF]

Cold Spring Harbor Perspectives in Medicine, 2013
The sensitive and broadly reactive character of the innate immune system makes it liable to activation by stress factors other than infection. Thermal and metabolic stresses experienced during the transplantation procedure are sufficient to trigger the innate immune response and also augment adaptive immunity in the presence of foreign antigen on the ...
Farrar, Conrad A, Kupiec-Weglinski, Jerzy W, Sacks, Steven H   +2 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Innate Immune Sensing by Cells of the Adaptive Immune System

Frontiers in Immunology, 2020
Sensing of microbes or of danger signals has mainly been attributed to myeloid innate immune cells. However, T and B cells also express functional pattern recognition receptors (PRRs).
Tanja Stögerer, Simona Stäger
doaj   +1 more source

Toll-like receptors in cerebral ischemic inflammatory injury [PDF]

, 2011
Cerebral ischemia triggers acute inflammation, which has been associated with an increase in brain damage. The mechanisms that regulate the inflammatory response after cerebral ischemia are multifaceted.
Yan-Chun Wang, Sen Lin, Qing-Wu Yang
core   +1 more source

Testicular defense systems: immune privilege and innate immunity [PDF]

Cellular & Molecular Immunology, 2014
The mammalian testis possesses a special immunological environment because of its properties of remarkable immune privilege and effective local innate immunity. Testicular immune privilege protects immunogenic germ cells from systemic immune attack, and local innate immunity is important in preventing testicular microbial infections.
Shutao, Zhao, Weiwei, Zhu, Shepu, Xue, Daishu, Han   +3 more
openaire   +2 more sources