Results 181 to 190 of about 15,540,926 (301)

Engineered Microvascular Model of the Blood–Brain–Tumor Barrier Reveals Endothelial Remodeling in Diffuse Midline Glioma

Advanced Healthcare Materials, EarlyView.
We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett, Yann S. Vanrobaeys, Tessy Teboh, Zakiya Smith, Anderson Scott, Cynthia Hajal, Paula T. Hammond, Joelle P. Straehla   +7 more
wiley   +1 more source

The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity. [PDF]

Int J Mol Sci
Kunyk D, Plotnikova M, Bespalov M, Shevyrev D, Klotchenko S, Ivanov R, Reshetnikov V.   +6 more
europepmc   +1 more source

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics. [PDF]

Int J Mol Sci, 2023
Muslimov A, Tereshchenko V, Shevyrev D, Rogova A, Lepik K, Reshetnikov V, Ivanov R.   +6 more
europepmc   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Innate immune system for a crosstalk of sperm-egg-uterine epithelium towards fertility: Toll-like receptor 2 as a physiological sensor. [PDF]

J Reprod Dev
Akthar I, Mansouri A, Miyamoto A.
europepmc   +1 more source

Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. [PDF]

Front Endocrinol (Lausanne), 2023
Nigi L, Laiho JE, Hyöty H, Dotta F.
europepmc   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Penaeus monodon fibrinogen-related lectin interacts with lipopolysaccharide and β-1,3-glucan binding protein to activate the innate immune system. [PDF]

Biochem J
Wilasluck P, Sukonthamarn P, Tassanakajon A, Wangkanont K.   +3 more
europepmc   +1 more source

Fishing Innate Immune System Properties through the Transcriptomic Single-Cell Data of Teleostei. [PDF]

Biology (Basel), 2023
Bobrovskikh AV, Zubairova US, Doroshkov AV.   +2 more
europepmc   +1 more source