Results 71 to 80 of about 15,540,926 (301)

Development of the Innate Immune Response in NestlingTree Swallows (Tachycineta bicolor) [PDF]

, 2009
The innate immune system provides an immediate, short term, first line of defense from pathogens; its appearance early in development in vertebrates is evidence of its critical importance.
Stambaugh, T.R.
core  

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2 [PDF]

, 2013
Innate immune recognition is the first line of host defense against invading microorganisms. It is a based on the detection, by pattern recognition receptors (PRRs), of invariant molecular signatures that are unique to microorganisms.
Alain Vercellone, Nigou, Jerome, Iain Sutcliffe, Besra, Gurdyal, Mishra Arun K., Arun K Mishra, Jérôme Nigou, Blanc Landry, Sutcliffe Iain, Mishra, Arun, Gurdyal S Besra, Castanier Romain, Ray, Aurélie, Romain Castanier, Vercellone, Alain, Ray Aurélie, Mishra, Arun K, Castanier, Romain, Landry Blanc, Blanc, Landry, Vercellone Alain, Nigou Jérôme, Besra, Gurdyal S; id_orcid, Sutcliffe, Iain, Besra Gurdyal S., Mishra, Arun K., Aurélie Ray   +26 more
core   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Immune-mediated competition in rodent malaria is most likely caused by induced changes in innate immune clearance of merozoites [PDF]

, 2014
Malarial infections are often genetically diverse, leading to competitive interactions between parasites. A quantitative understanding of the competition between strains is essential to understand a wide range of issues, including the evolution of ...
Savill Nicholas Jon, Lars Raberg, Nick Savill, Nicholas Jon Savill, Råberg Lars, Jayanthi Santhanam, Nicholas Jon Savill (513813), Santhanam, Jayanthi, Råberg, Lars, Andrew F Read, Jayanthi Santhanam (513812), Santhanam Jayanthi, Råberg, Lars,, Savill, Nicholas Jon, Andrew Read, Andrew F. Read (130517), Read, Andrew F, Lars Råberg (240621), Read Andrew F., Andrew F. Read   +19 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

'Towards a Conceptual Framework for Innate Immunity' [PDF]

, 2005
Innate immunity now occupies a central role in immunology. However, artificial immune system models have largely been inspired by adaptive not innate immunity.
Aickelin, Uwe, Aickelin, U, Twycross, J, Uwe Aickelin, Jamie Twycross, Twycross, Jamie   +5 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances

Frontiers in Pain Research
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect in patients undergoing chemotherapy. Many commonly used chemotherapeutic agents simultaneously induce neurotoxicity and modulate the immune system.
Nana Dong, Tongtong Lin
doaj   +1 more source

Innate Pathways of Immune Activation in Transplantation

Journal of Transplantation, 2010
Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells.
Todd V. Brennan, Keri E. Lunsford, Paul C. Kuo   +2 more
doaj   +1 more source

Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey. [PDF]

, 2010
BACKGROUND: Deficiencies in vitamins and mineral elements are important causes of morbidity in developing countries, possibly because they lead to defective immune responses to infection.
Veenemans, J., Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Hans Verhoef, Matthew McCall, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Savelkoul, Huub Fj, Erasto V Mbugi, Savelkoul Huub FJ, John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +36 more
core   +1 more source