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Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract
Viruses, 2021 The innate immune system is the host’s first line of immune defence against any invading pathogen. To establish an infection in a human host the influenza virus must replicate in epithelial cells of the upper respiratory tract. However, there are several
Edin J. Mifsud, Miku Kuba, Ian G. Barr
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Evolution of innate immune systems* [PDF]
Biochemistry and Molecular Biology Education, 2005 AbstractInnate immunity is the oldest form of defense and is found to some degree in all species. It predates the adaptive immune system, consisting of antibodies, B cells, T cells, and the major histocompatibility antigens. These are found only in higher vertebrates and have been the focus of the majority of immunological research, particularly in ...
Jakob, Suckale +2 more
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Aging of the innate immune system [PDF]
Current Opinion in Immunology, 2010 The innate immune system is composed of a network of cells including neutrophils, NK and NKT cells, monocytes/macrophages, and dendritic cells that mediate the earliest interactions with pathogens. Age-associated defects are observed in the activation of all of these cell types, linked to compromised signal transduction pathways including the Toll-like
Albert C, Shaw +4 more
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The Innate Immune System and Transplantation [PDF]
Cold Spring Harbor Perspectives in Medicine, 2013 The sensitive and broadly reactive character of the innate immune system makes it liable to activation by stress factors other than infection. Thermal and metabolic stresses experienced during the transplantation procedure are sufficient to trigger the innate immune response and also augment adaptive immunity in the presence of foreign antigen on the ...
Farrar, Conrad A +2 more
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The Chemokine System in Innate Immunity [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Chemokines are chemotactic cytokines that control the migration and positioning of immune cells in tissues and are critical for the function of the innate immune system. Chemokines control the release of innate immune cells from the bone marrow during homeostasis as well as in response to infection and inflammation.
Caroline L, Sokol, Andrew D, Luster
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Boletim do Instituto de Pesca, 2019 Linking proprieties of adhesion, infectious capacities and antibiotic resistance of pathogen bacteria could help to treat fish diseases. Adhesions of ten fish pathogenic bacteria were tested in microtiter plates vacant, coated with skin or gut mucus ...
Said Ben Hamed +5 more
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Engineering physical microenvironments to study innate immune cell biophysics
APL Bioengineering, 2022 Innate immunity forms the core of the human body's defense system against infection, injury, and foreign objects. It aims to maintain homeostasis by promoting inflammation and then initiating tissue repair, but it can also lead to disease when ...
Nikita Kalashnikov, Christopher Moraes
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Frontiers in Aging Neuroscience, 2021 Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging.
Md. Mahiuddin Ahmed +17 more
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Chronic wounds alter the proteome profile in skin mucus of farmed gilthead seabream
BMC Genomics, 2017 Background Skin and its mucus are known to be the first barrier of defence against any external stressors. In fish, skin wounds frequently appear as a result of intensive culture and also some diseases have skin ulcers as external clinical signs. However,
Héctor Cordero +3 more
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Systems biology of innate immunity [PDF]
Cellular Immunology, 2006 Systems Biology has emerged as an exciting research approach in molecular biology and functional genomics that involves a systematic use of genomic, proteomic, and metabolomic technologies for the construction of network-based models of biological processes.
Jesper, Tegnér +4 more
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