Results 191 to 200 of about 1,626,946 (340)

The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity. [PDF]

Int J Mol Sci
Kunyk D, Plotnikova M, Bespalov M, Shevyrev D, Klotchenko S, Ivanov R, Reshetnikov V.   +6 more
europepmc   +1 more source

The Dual Role of the Innate Immune System in the Effectiveness of mRNA Therapeutics. [PDF]

Int J Mol Sci, 2023
Muslimov A, Tereshchenko V, Shevyrev D, Rogova A, Lepik K, Reshetnikov V, Ivanov R.   +6 more
europepmc   +1 more source

Recognition of Endogenous Nucleic Acids by the Innate Immune System.

Immunity, 2016
Axel Roers, Björn Hiller, V. Hornung
semanticscholar   +1 more source

Dual‐Peptide Nanoplatform: Mesoporous Silica Nanoparticles Functionalized With a Cell‐Penetrating Peptide and Loaded With Rationally Designed Antimicrobial Peptides for Tuberculosis Therapy

Advanced Healthcare Materials, EarlyView.
Machine learning–guided engineering of a plectasin‐derived peptide yields DC05, a potent antimycobacterial candidate. Encapsulation into tuftsin‐functionalized mesoporous silica nanoparticles enhances intracellular delivery, stability, and activity against Mycobacterium tuberculosis while maintaining low cytotoxicity and minimal hemolysis. The combined
Christian S. Carnero Canales, Cesar Augusto Roque‐Borda, Ana Carolina Cerqueira Negri, Oswaldo Ramirez Delgado, Letícia Oliveira Catarin Nunes, Flávia Aparecida Resende, Hernane Barud, Norival Alves Santos‐Filho, Saulo Santesso Garrido, Karen Cristina Oliveira, Alexandra Ivo de Medeiros, Rafael Miguel Sábio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system. [PDF]

Cancer Cell Int
Joannes L, Dupont L, Stock L, Arpigny E, Hubert P, Ancion M, Luyckx M, Abinet J, Peng W, Calaldo D, Noel A, Marichal T, Herfs M, Deroanne C, Colige A.   +14 more
europepmc   +1 more source

Editorial: The contribution of viruses and innate immune system in the pathogenesis of type 1 diabetes. [PDF]

Front Endocrinol (Lausanne), 2023
Nigi L, Laiho JE, Hyöty H, Dotta F.
europepmc   +1 more source

Advanced 3D Platforms for Modeling CNS Neuroinflammation: Cell Integration, Techniques, and Challenges

Advanced Healthcare Materials, EarlyView.
This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source

Penaeus monodon fibrinogen-related lectin interacts with lipopolysaccharide and β-1,3-glucan binding protein to activate the innate immune system. [PDF]

Biochem J
Wilasluck P, Sukonthamarn P, Tassanakajon A, Wangkanont K.   +3 more
europepmc   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Biological significance of extracellular vesicles in innate immune system. [PDF]

Innate Immun
Jadamba B, Park J, Lee H.
europepmc   +1 more source