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Innate Immune System Cells in Atherosclerosis
Archives of Medical Research, 2014Atherosclerosis is a chronic inflammatory disease of the arterial wall characterized by innate and adaptive immune system involvement. A key component of atherosclerotic plaque inflammation is the persistence of different innate immune cell types including mast cells, neutrophils, natural killer cells, monocytes, macrophages and dendritic cells ...
Luis Chávez-Sánchez
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The porcine innate immune system: An update [PDF]
Developmental and Comparative Immunology, 2014 Over the last few years, we have seen an increasing interest and demand for pigs in biomedical research. Domestic pigs (Sus scrofa domesticus) are closely related to humans in terms of their anatomy, genetics, and physiology, and often are the model of ...
Artur Summerfield +2 more
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Innate Immunity in the Mucosal Immune System
Current Pharmaceutical Design, 2006The mucosal immune system is equipped with unique innate and acquired defense mechanisms which provide a first line of protection against ingested and inhaled infectious agents. Peyer's patches (PPs) and nasopharynx-associated lymphoid tissue (NALT) have been shown to be important inductive sites for the initiation of the acquired phase of antigen ...
Tomonori, Nochi, Hiroshi, Kiyono
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Interaction of Viral Capsid-Derived Virus-Like Particles (VLPs) with the Innate Immune System [PDF]
Vaccines, 2018 Virus-like particles (VLPs) derived from viral nucleocapsids are an important class of nanoparticles. The structure, uniformity, stability, and function of these VLPs have attracted scientists in utilizing them as a unique tool in various applications in
Ariane Karla Cruz Gomes +2 more
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Innate Immunity in Systemic Sclerosis
Current Rheumatology Reports, 2017Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has defined three hallmarks: Small vessel vasculopathy, production of autoantibodies and fibroblast dysfunction. The exact aetiology of the disease remains unknown, due to the complex nature of the cellular signalling pathways involved. However, there is strong and consistent evidence
Christopher, Dowson +3 more
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The aging innate immune system
Current Opinion in Immunology, 2005Advanced age is associated with a breakdown of the epithelial barriers of the skin, lung and gastrointestinal tract, which enables invasion of delicate mucosal tissues by pathogenic organisms. Thus, there is an increased challenge for the innate immune system in aged subjects, as the portal of pathogen entry becomes more readily disturbed.
Christian R, Gomez +2 more
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Adaptation in the innate immune system and heterologous innate immunity
Cellular and Molecular Life Sciences, 2014The innate immune system recognizes deviation from homeostasis caused by infectious or non-infectious assaults. The threshold for its activation seems to be established by a calibration process that includes sensing of microbial molecular patterns from commensal bacteria and of endogenous signals.
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The immune memory of innate immune systems
International ImmunologyAbstract Immune memory has long been considered a function specific to adaptive immune systems; however, adaptive immune memory alone has not fully explained the mechanism by which vaccines exert their protective effects against nontarget pathogens.
Yasuhiro Kato, Atsushi Kumanogoh
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Innate immunity in the nervous system
2009The complement (C) system plays a central role in innate immunity and bridges innate and adaptive immune responses. A fine balance of C activation and regulation mediates the elimination of invading pathogens and the protection of the host from excessive C deposition on healthy tissues.
V, Ramaglia, F, Baas
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