H2O2‐Generating Advanced Nanomaterials for Cancer Treatment
Advanced Functional Materials, EarlyView.H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie +8 more
wiley +1 more source
Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system [PDF]
, 2004 Cuong Vuong +6 more
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Advanced Functional Materials, EarlyView.This review highlights recent advances in engineering artificial antigen‐presenting cells (aAPCs) as alternatives to dendritic cells for T cell expansion. Key design principles inspired by the immunological synapse are discussed, with emphasis on strategies for polyclonal and antigen‐specific T cell expansion.
Nguyen Thi Nguyen, Yu Seok Youn
wiley +1 more source
Toll-like receptors and the host defense against microbial pathogens: bringing specificity to the innate-immune system [PDF]
, 2004 Mihai G. Netea +3 more
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Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system [PDF]
, 2004 Adrian Erlebacher +3 more
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Multi-receptor detection of individual bacterial products by the innate immune system
Nature reviews. Immunology, 2017 Karen J. Kieser, Jonathan C. Kagan
semanticscholar +1 more source
Flow‐Induced Vascular Remodeling on‐Chip: Implications for Anti‐VEGF Therapy
Advanced Functional Materials, EarlyView.Flow‐induced vascular remodeling plays a critical role in network stabilization and function. Using a vasculature‐on‐chip system, this study reveals how physiological VEGF levels and flow affect vascular remodeling and provides insights into tumor vessel normalization.
Fatemeh Mirzapour‐Shafiyi +6 more
wiley +1 more source
If the ‘Adaptive’ Immune System Can Recognize a Significant Portion of the Pathogenic Universe to Which the ‘Innate’ Immune System is Blind, Then… [PDF]
, 2004 Melvin Cohn
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Innate Immune System in the Context of Radiation Therapy for Cancer. [PDF]
Cancers (Basel), 2023 Boopathi E, Den RB, Thangavel C.
europepmc +1 more source