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Modelling molecular differences in the innate immune system responses of chickens and ducks to highly pathogenic avian influenza virus

Wood T, An G, Bryant CE, Ferguson BJ.
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The aging innate immune system

Current Opinion in Immunology, 2005
Advanced age is associated with a breakdown of the epithelial barriers of the skin, lung and gastrointestinal tract, which enables invasion of delicate mucosal tissues by pathogenic organisms. Thus, there is an increased challenge for the innate immune system in aged subjects, as the portal of pathogen entry becomes more readily disturbed.
Christian R, Gomez, Eric D, Boehmer, Elizabeth J, Kovacs   +2 more
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Innate Immunity in Systemic Sclerosis

Current Rheumatology Reports, 2017
Systemic sclerosis (SSc) is a heterogeneous autoimmune disease which has defined three hallmarks: Small vessel vasculopathy, production of autoantibodies and fibroblast dysfunction. The exact aetiology of the disease remains unknown, due to the complex nature of the cellular signalling pathways involved. However, there is strong and consistent evidence
Christopher, Dowson, Nathan, Simpson, Laura, Duffy, Steven, O'Reilly   +3 more
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Immune system and Innate Immunity

2020
Peter Kam, Ian Power, Michael J. Cousins, Philip J. Siddal   +3 more
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Innate Immunity in the Mucosal Immune System

Current Pharmaceutical Design, 2006
The mucosal immune system is equipped with unique innate and acquired defense mechanisms which provide a first line of protection against ingested and inhaled infectious agents. Peyer's patches (PPs) and nasopharynx-associated lymphoid tissue (NALT) have been shown to be important inductive sites for the initiation of the acquired phase of antigen ...
Tomonori, Nochi, Hiroshi, Kiyono
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Role of innate immune system in the pathogenesis of ankylosing spondylitis.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018
Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a severe form of arthritis with pain and stiffness in the axial skeleton.
Negar Vanaki, S. Aslani, A. Jamshidi, M. Mahmoudi   +3 more
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Adaptation in the innate immune system and heterologous innate immunity

Cellular and Molecular Life Sciences, 2014
The innate immune system recognizes deviation from homeostasis caused by infectious or non-infectious assaults. The threshold for its activation seems to be established by a calibration process that includes sensing of microbial molecular patterns from commensal bacteria and of endogenous signals.
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The immune memory of innate immune systems

International Immunology
Abstract Immune memory has long been considered a function specific to adaptive immune systems; however, adaptive immune memory alone has not fully explained the mechanism by which vaccines exert their protective effects against nontarget pathogens.
Yasuhiro Kato, Atsushi Kumanogoh
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Neutrophils: Cinderella of innate immune system

International Immunopharmacology, 2010
Neutrophils are the first line of innate immune defense against infectious diseases. However, since their discovery by Elie Metchnikoff, they have always been considered tissue-destructive cells responsible for inflammatory tissue damage occurring during acute infections.
Kumar, V., Sharma, A.
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