Results 71 to 80 of about 18,668,522 (300)

Development of the Innate Immune Response in NestlingTree Swallows (Tachycineta bicolor) [PDF]

, 2009
The innate immune system provides an immediate, short term, first line of defense from pathogens; its appearance early in development in vertebrates is evidence of its critical importance.
Stambaugh, T.R.
core  

Gram-positive bacterial lipoglycans based on a glycosylated diacylglycerol lipid anchor are microbe-associated molecular patterns recognized by TLR2 [PDF]

, 2013
Innate immune recognition is the first line of host defense against invading microorganisms. It is a based on the detection, by pattern recognition receptors (PRRs), of invariant molecular signatures that are unique to microorganisms.
Alain Vercellone, Nigou, Jerome, Iain Sutcliffe, Besra, Gurdyal, Mishra Arun K., Arun K Mishra, Jérôme Nigou, Blanc Landry, Sutcliffe Iain, Mishra, Arun, Gurdyal S Besra, Castanier Romain, Ray, Aurélie, Romain Castanier, Vercellone, Alain, Ray Aurélie, Mishra, Arun K, Castanier, Romain, Landry Blanc, Blanc, Landry, Vercellone Alain, Nigou Jérôme, Besra, Gurdyal S; id_orcid, Sutcliffe, Iain, Besra Gurdyal S., Mishra, Arun K., Aurélie Ray   +26 more
core   +2 more sources

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances

Frontiers in Pain Research
Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect in patients undergoing chemotherapy. Many commonly used chemotherapeutic agents simultaneously induce neurotoxicity and modulate the immune system.
Nana Dong, Tongtong Lin
doaj   +1 more source

Alterations in early cytokine-mediated immune responses to Plasmodium falciparum infection in Tanzanian children with mineral element deficiencies: a cross-sectional survey. [PDF]

, 2010
BACKGROUND: Deficiencies in vitamins and mineral elements are important causes of morbidity in developing countries, possibly because they lead to defective immune responses to infection.
Veenemans, J., Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Hans Verhoef, Matthew McCall, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Savelkoul, Huub Fj, Erasto V Mbugi, Savelkoul Huub FJ, John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +36 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Innate Pathways of Immune Activation in Transplantation

Journal of Transplantation, 2010
Studies of the immune mechanisms of allograft rejection have predominantly focused on the adaptive immune system that includes T cells and B cells.
Todd V. Brennan, Keri E. Lunsford, Paul C. Kuo   +2 more
doaj   +1 more source

InnateDB: systems biology of innate immunity and beyond—recent updates and continuing curation [PDF]

, 2012
peer-reviewedInnateDB (http://www.innatedb.com) is an integrated analysis platform that has been specifically designed to facilitate systems-level analyses of mammalian innate immunity networks, pathways and genes.
Brinkman, Fiona S. L., Laird, Matthew R, Amir K. Foroushani, David J. Lynn, Anastasia Sribnaia, Lynn, David J, Lo, Raymond, Raymond Lo, Foroushani, Amir K., Winsor, Geoffrey L, Breuer, Karin, Chen, Carol, Robert E. W. Hancock, Matthew R. Laird, Carol Chen, Geoffrey L. Winsor, Sribnaia, Anastasia, Hancock, Robert E.W., Karin Breuer, Fiona S. L. Brinkman   +19 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source