Results 11 to 20 of about 2,416,042 (300)
Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
Nature Communications, 2022 Evidence exists that the typically antiviral signaling mediator STING is, counterintuitively, needed for optimal human rhinovirus infection. Here the authors confirm this finding and show how human rhinovirus can reduce stored Ca2+ levels to drive this ...
Martha Triantafilou +11 more
doaj +1 more source
Trained Immunity: Reprogramming Innate Immunity in Health and Disease.
Annual Review of Immunology, 2021 Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has shifted: Cells of the innate immune system appear to be able to gain memory characteristics ...
S. Bekkering +4 more
semanticscholar +1 more source
Nature Communications, 2023 The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined,
L. S. Tran +26 more
doaj +1 more source
, 2022 AbstractResearch on the innate immunity has accelerated over the last decades. The main reason for this has been the discovery of receptors recognizing danger molecules from pathogens. This has been facilitated through genome and transcriptome sequencing of different fish species.
Dalmo, Roy Ambli, Bøgwald, Jarl
openaire +2 more sources
Journal of Extracellular Vesicles, 2021 Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue.
Christina F. Budden +5 more
doaj +1 more source
Scientific Reports, 2021 Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection.
Pragya Prakash +2 more
doaj +1 more source
ATP-binding and hydrolysis of human NLRP3
Communications Biology, 2022 Analysis of the inflammasome-forming protein NLRP3 provides insights into the function of conserved residues in the ATP-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activation.
Rebecca Brinkschulte +10 more
doaj +1 more source
Periphery and brain, innate and adaptive immunity in Parkinson’s disease
Acta Neuropathologica, 2021 Parkinson’s disease (PD) is a neurodegenerative disorder where alpha-synuclein plays a central role in the death and dysfunction of neurons, both, in central, as well as in the peripheral nervous system.
A. Harms +2 more
semanticscholar +1 more source
libtissue - implementing innate immunity [PDF]
, 2006 In a previous paper the authors argued the case for incorporating ideas from innate immunity into articficial immune systems (AISs) and presented an outline for a conceptual framework for such systems.
Aickelin, Uwe, Twycross, Jamie
core +3 more sources
Clinical & Translational Immunology, 2023 Objectives Novel host‐targeted therapeutics could treat severe influenza A virus (IAV) infections, with reduced risk of drug resistance. LAT8881 is a synthetic form of the naturally occurring C‐terminal fragment of human growth hormone.
Christopher M Harpur +7 more
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