Results 11 to 20 of about 2,613,171 (336)
Nature Communications, 2023 The interleukin-1 family members, IL-1β and IL-18, are processed into their biologically active forms by multi-protein complexes, known as inflammasomes. Although the inflammasome pathways that mediate IL-1β processing in myeloid cells have been defined,
L. S. Tran +26 more
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Journal of Extracellular Vesicles, 2021 Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammation and adaptive immunity. These mechanisms evolved to curb the spread of microbes and to induce repair of the damaged tissue.
Christina F. Budden +5 more
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Scientific Reports, 2021 Drosophila immune deficiency (IMD) pathway is similar to the human tumor necrosis factor receptor (TNFR) signaling pathway and is preferentially activated by Gram-negative bacterial infection.
Pragya Prakash +2 more
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ATP-binding and hydrolysis of human NLRP3
Communications Biology, 2022 Analysis of the inflammasome-forming protein NLRP3 provides insights into the function of conserved residues in the ATP-binding site of NLRP3 and the correlation of ATP hydrolysis with inflammasome activation.
Rebecca Brinkschulte +10 more
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libtissue - implementing innate immunity [PDF]
, 2006 In a previous paper the authors argued the case for incorporating ideas from innate immunity into articficial immune systems (AISs) and presented an outline for a conceptual framework for such systems.
Aickelin, Uwe, Twycross, Jamie
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The evolution of resistance through costly acquired immunity [PDF]
, 2004 We examine the evolutionary dynamics of resistance to parasites through acquired immunity. Resistance can be achieved through the innate mechanisms of avoidance of infection and reduced pathogenicity once infected, through recovery from infection and ...
Boots M., Michael Boots, Roger G. Bowers
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Integrative Genomics Reveals the Genetics and Evolution of the Honey Bee’s Social Immune System [PDF]
, 2019 Social organisms combat pathogens through individual innate immune responses or through social immunity—behaviors among individuals that limit pathogen transmission within groups.
Currie, Rob +12 more
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Innate Immunity and Cancer Pathophysiology.
Annual Review of Pathology, 2021 Chronic inflammation increases the risk of several cancers, including gastric, colon, and hepatic cancers. Conversely, tumors, similar to tissue injury, trigger an inflammatory response coordinated by the innate immune system.
L. Maiorino +3 more
semanticscholar +1 more source
A functional DC cross talk promotes human ILC homeostasis in humanized mice
Blood Advances, 2017 : Humanized mice harboring human hematopoietic systems offer a valuable small-animal model to assess human immune responses to infection, inflammation, and cancer.
Silvia Lopez-Lastra +8 more
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The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans
Nature Communications, 2020 lncRNAs are transcriptional regulators, but little is known of them functioning as negative feedback regulators of inflammation in humans. Here, the authors show that the human lncRNA LUCAT1 sequesters STAT1 to limit JAK/STAT signaling and the ...
Shiuli Agarwal +7 more
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