Results 191 to 200 of about 473,545 (264)

Toll-like receptors in innate immunity and inflammation: from fundamental biology to clinic insights. [PDF]

Immun Inflamm
Qian C, Cao X, Hoffmann JA.
europepmc   +1 more source

A Wireless, Passive Multimodal Wearable Sensor With Decoupled Sensing Capabilities

Advanced Materials, EarlyView.
A wireless passive multimodal electronic skin is presented for the simultaneous perception of pressure, humidity, and odor through a frequency‐divided LC resonator array. The decoupled sensing architecture suppresses cross‐interference and enables independent signal readout under superimposed stimuli while maintaining high stability.
Wenjiang Han, Heng Xiao, Tianshuang Wang, Xiaoran Ding, Liupeng Zhao, Seokjoo Cho, Peng Sun, Inkyu Park, Geyu Lu   +8 more
wiley   +1 more source

Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment. [PDF]

Front Aging
Kou W, Lu X, Zhang Z, Liu K, Liu Z, Jiang B, Wang H, Li J, Lu H, Guo C, Cao L, Zhang X.   +11 more
europepmc   +1 more source

From Payload‐First Toward Dual‐Mechanism Antibody–Drug Conjugates

Advanced Materials, EarlyView.
Conjugation converts potent antibodies into underexposed carriers. This perspective defines the antibody exposure deficit and maps a mechanism‐first design space from payload‐first to antibody‐first ADC architectures, integrating DAR, linker chemistry, and Fc engineering to guide rational design of constructs that balance targeted cytotoxicity with ...
Xavier Pivot, Sebastian Jung, Sébastien Harlepp, Alexandre Detappe   +3 more
wiley   +1 more source

Stalled translation on transcripts cleaved by RNase L activates signaling important for innate immunity. [PDF]

RNA
Karasik A, Jones GD, Guydosh NR.
europepmc   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

SENP5 enhances antiviral innate immunity by promoting AURKA-dependent STAT2 phosphorylation. [PDF]

Cell Commun Signal
Song S, Kan Y, Zhou M, Jiang Y, Tang Y, Luo H, Hu Y.   +6 more
europepmc   +1 more source

Programmable Functional Silicification of DNA Origami Nanostructures

Advanced Materials, EarlyView.
This work introduces additional functionality into silica‐coated DNA origami nanostructures using non‐standard silica precursors. A fluorescent precursor enables enhanced intracellular tracking, while a disulfide‐containing reagent yields redox‐responsive, degradable silica coatings.
Anna V. Baptist, Lasse Guericke, Philipp Mauker, Oliver Thorn‐Seshold, Amelie Heuer‐Jungemann   +4 more
wiley   +1 more source

A key regulator of missing-self innate immunity is polymorphic and under diversifying selection. [PDF]

Mol Biol Evol
Notarnicola RF, Herdegen-Radwan M, Różańska-Wróbel J, Konczal M, Przesmycka K, Kotlík P, Babik W, Radwan J.   +7 more
europepmc   +1 more source

Multilayered Digital Microfluidic Chip for Cell‐Based Assays

Advanced Materials Interfaces, EarlyView.
A multilayered digital microfluidic (mDMF) chip architecture is introduced to improve throughput and robustness in cell‐based assays. By multilayering electrode components and dielectric layers on glass, this design significantly reduces actuation voltage, maintains reliability, and enables expansion of the operational area with minimum current leakage.
Mert Ozden, Oksana K. Savchak, Burcu Gumuscu   +2 more
wiley   +1 more source