Results 121 to 130 of about 128,560 (293)

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Basophils promote innate lymphoid cell responses in inflamed skin.

, 2014
Type 2 inflammation underlies allergic diseases such as atopic dermatitis, which is characterized by the accumulation of basophils and group 2 innate lymphoid cells (ILC2s) in inflamed skin lesions.
Wang, Kelvin, Noti, Mario, Artis, David, Kim, Brian S, Saenz, Steven A, Brestoff, Jonathan R, Tait Wojno, Elia D, Siracusa, Mark C, Fung, Thomas C, Monticelli, Laurel A, Kubo, Masato   +10 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

Advanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang, Qin Wang, Zhuo Yao, Qing Wang, Yongtao Ji, Minqi Yang, Meng Wang, Shiyi Shao, Xinyu Zhao, Fu Zhang, Tingbo Liang, Qida Hu   +11 more
wiley   +1 more source

Tissue-Resident Lymphocytes Across Innate and Adaptive Lineages

Frontiers in Immunology, 2018
Lymphocytes are an integral component of the immune system. Classically, all lymphocytes were thought to perpetually recirculate between secondary lymphoid organs and only traffic to non-lymphoid tissues upon activation. In recent years, a diverse family
Chun Chou, Ming O. Li
doaj   +1 more source

Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity

, 2014
The impact of nutritional status during fetal life on the overall health of adults has been recognized; however, dietary effects on the developing immune system are largely unknown. Development of secondary lymphoid organs occurs during embryogenesis and
Elaine Dzierzak, Rita G. Domingues, Domingues, R.G., Dzierzak, E., Ribeiro, Hélder, Littman, D.R., Godinho-Silva, Cristina, Mizee, Mark R, Ibiza, S., Mebius, R.E., O'Toole, T, Molenaar, R., Reina E. Mebius, Henrique Veiga-Fernandes, Domingues, Rita G, Habani, Y., Yasmin Habani, Ribeiro, H., Schooneman, Dennis, Labao-Almeida, C., Inês Barbosa, Dennis Schooneman, Molenaar, Rosalie, Moreira-Santos, L., Stefan Schulte-Merker, Veiga-Fernandes, Henrique, Tanja Konijn, Santori, FR, Van De Pavert, SA, Habani, Yasmin, Mebius, Reina E, Moreira-Santos, Lara, Lara Moreira-Santos, Littman, DR, Schooneman, D., Konijn, T, Almeida, Francisca F, O'Toole, Tom, Schulte-Merker, Stefan, Hélder Ribeiro, Mark R. Mizee, Mebius, RE (Reina), Konijn, T., Ferreira, Manuela, Gera Goverse, Mizee, M.R., Barbosa, Inês, Dzierzak, Elaine, Ibiza, Sales, Simas, J Pedro, Haak, E., Ferreira, M., Veiga-Fernandes, H., Oâ Toole, T, Tom O’Toole, Moreira-Santos, L, Haak, E, Sales Ibiza, O'Toole, T.G., Serge A. van de Pavert, Goverse, G, Littman, Dan R, Barbosa, I., Haak, Esther, Schulte-Merker, S., van de Pavert, S.A., Konijn, Tanja, Schooneman, D, Goverse, Gera, Santori, F.R., Schulte-Merker, S, Santori, Fabio R, Molenaar, R, Habani, Y, Mebius, RE, Carlos Labão-Almeida, Fabio R. Santori, Ribeiro, H, Godinho-Silva, C, Ferreira, M, Mizee, MR, Almeida, FF, Labão-Almeida, C, Domingues, RG, Godinho-Silva, C., Ibiza, S, Simas, JP, Rosalie Molenaar, Goverse, G., Veiga-Fernandes, H, Dzierzak, E, Almeida, F.F., Francisca F. Almeida, Cristina Godinho-Silva, Labão-Almeida, Carlos, Esther Haak, Barbosa, I, Manuela Ferreira, van de Pavert, Serge A, Dan R. Littman, J. Pedro Simas, Molenaar, R (Peter), Simas, J.P.   +102 more
core   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]

F1000Research, 2012
B lymphocytes promote the initial innate interferon response to viral pathogens without the need for antigen receptor activation. B cell dependent IFN production requires the cytokine, lymphotoxin-β.
Carl F Ware, Chris Benedict
doaj   +1 more source

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source

The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells

, 2014
Interleukin-22 (IL-22) plays a critical role in mucosal defense, although the molecular mechanisms that ensure IL-22 tissue distribution remain poorly understood.
Di Santo, James P., Serafini, Nicolas, Verrier, Thomas, Satoh-Takayama, Naoko, Di Santo, James P, DiSanto, JamesP., Frankel, Gad, Renauld, Jean-Christophe, Rekiki, Abdessalem   +8 more
core   +1 more source