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Transcriptional regulation of innate lymphoid cell fate
Nature Reviews Immunology, 2015 International audienceInnate lymphoid cells (ILCs) are a recently described family of lymphoid effector cells that have important roles in immune defence, inflammation and tissue remodelling.
Nicolas Serafini +2 more
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Development of innate lymphoid cells
Nature Immunology, 2016Innate lymphoid cells (ILCs) are a family of immune effector cells that have important roles in host defense, metabolic homeostasis and tissue repair but can also contribute to inflammatory diseases such as asthma and colitis. These cells can be categorized into three groups on the basis of the transcription factors that direct their function and the ...
Erin C, Zook, Barbara L, Kee
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Innate lymphoid cells in atherosclerosis
European Journal of Pharmacology, 2017The family of innate lymphoid cells (ILCs) consisting of NK cells, lymphoid tissue inducer cells and the 'helper'-like ILC subsets ILC1, ILC2 and ILC3 have been shown to have important roles in protection against microbes, regulation of inflammatory diseases and involved in allergic reactions.
Daniel, Engelbertsen, Andrew H, Lichtman
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Innate Lymphoid Cells in Cancer
Cancer Immunology Research, 2015AbstractThe world of lymphocytes has recently expanded. A group of cells, innate lymphoid cells (ILC), has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells and lymphoid tissue–inducer (LTi) cells. NK cells recognize a vast array of tumor cells, which they help to eliminate through cytotoxicity
B. Vallentin +9 more
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Innate Lymphoid Cells of the Lung
Annual Review of Physiology, 2019Although, as the major organ of gas exchange, the lung is considered a nonlymphoid organ, an interconnected network of lung-resident innate cells, including epithelial cells, dendritic cells, macrophages, and natural killer cells is crucial for its protection. These cells provide defense against a daily assault by airborne bacteria, viruses, and fungi,
Jillian L, Barlow, Andrew N J, McKenzie
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The diversified class of immune cells known as innate lymphoid cells (ILCs), which lack altered antigen-specific receptors, is essential for the maintenance of immunological homeostasis, tissue repair, and protection against pathogens. They are the innate counterparts of CD4+ Th cells.
Ann Mary, Joseph +2 more
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Ann Mary, Joseph +2 more
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Innate lymphoid cells and asthma
Journal of Allergy and Clinical Immunology, 2014Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype characterized by TH2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes, such as asthma associated with exposure to air pollution, infection, or obesity, that
Sanhong, Yu +4 more
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2020
Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Innate lymphoid cells (ILCs) have come to the forefront of mucosal immunology, being recognized as prompt effectors against infection and injury, and as orchestrators of immune responses. The ILC subsets react to different cues in their local environment to mount qualitatively different effector responses, depending on the type of infection or tissue ...
Gerard Eberl, Nicholas Powell
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Immunophenotyping of Human Innate Lymphoid Cells
2019In the last years, the family of innate lymphocytes has been growing following the discovery of innate lymphoid cells (ILCs). ILCs are lymphocytes able to rapidly produce a wide range of soluble mediators in an antigen-independent fashion. So far, three main subsets of ILCs have been discovered, ILC1, ILC2, and ILC3, expressing respectively the ...
Trabanelli, Sara +2 more
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Neuronal regulation of innate lymphoid cells
Current Opinion in Immunology, 2019The cardinal signs of inflammation suggest a close connection between the nervous system and the immune system. However, the cellular and molecular basis of these interactions remains incompletely defined. Recent research has demonstrated that tissue-resident innate lymphoid cells (ILCs) obtain neuronal signals, particularly at mucosal barriers, where ...
Christoph Sn, Klose, David, Artis
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