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Immunophenotyping of Human Innate Lymphoid Cells
2019In the last years, the family of innate lymphocytes has been growing following the discovery of innate lymphoid cells (ILCs). ILCs are lymphocytes able to rapidly produce a wide range of soluble mediators in an antigen-independent fashion. So far, three main subsets of ILCs have been discovered, ILC1, ILC2, and ILC3, expressing respectively the ...
Trabanelli, Sara +2 more
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Neuronal regulation of innate lymphoid cells
Current Opinion in Immunology, 2019The cardinal signs of inflammation suggest a close connection between the nervous system and the immune system. However, the cellular and molecular basis of these interactions remains incompletely defined. Recent research has demonstrated that tissue-resident innate lymphoid cells (ILCs) obtain neuronal signals, particularly at mucosal barriers, where ...
Christoph Sn, Klose, David, Artis
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Innate lymphoid cells, precursors and plasticity
Immunology Letters, 2016Innate lymphoid cells (ILC) have only recently been recognized as a separate entity of the lymphoid lineage. Their subpopulations share common characteristics in terms of early development and major transcriptional circuitry with their related cousins of the T cell world.
Konrad, Gronke +2 more
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Innate Lymphoid Cells: The Innate Counterpart to T Helper Cells
2016Innate lymphoid cells (ILCs) are a recently discovered subset of innate immune cells that are capable of secreting great amounts of cytokines that have been found to influence effector cell activity. Chronic rhinosinusitis (CRS) in the absence (CRSsNP) or presence (CRSwNP) of nasal polyps has been characterized as type 1- and type 2-skewed ...
Caroline, Padro Dietz, Amber, Luong
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Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.
Science (New York, N.Y.), 2015Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of
Gérard, Eberl +3 more
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Epigenetic regulation of innate lymphoid cells
European Journal of ImmunologyAbstract Innate lymphoid cells (ILCs) lack antigen‐specific receptors and are considered the innate arm of the immune system, phenotypically and functionally mirroring CD4 + helper T cells.
Hanxiao, Sun, Jinxin, Qiu, Ju, Qiu
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Heterogeneity of type 2 innate lymphoid cells
Nature Reviews Immunology, 2022Hergen Spits +2 more
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Keeping time in group 3 innate lymphoid cells
Nature Reviews Immunology, 2020Qianli Wang +2 more
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Innate lymphoid cells — a proposal for uniform nomenclature
Nature Reviews Immunology, 2013Hergen Spits +2 more
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