Results 31 to 40 of about 78,417 (160)

Modulation of Wnt Signaling Enhances Inner Ear Organoid Development in 3D Culture.

PLoS ONE, 2016
Stem cell-derived inner ear sensory epithelia are a promising source of tissues for treating patients with hearing loss and dizziness. We recently demonstrated how to generate inner ear sensory epithelia, designated as inner ear organoids, from mouse ...
Rachel E DeJonge, Xiao-Ping Liu, Christopher R Deig, Stefan Heller, Karl R Koehler, Eri Hashino   +5 more
doaj   +1 more source

Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction

Communications Medicine, 2021
Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness.
Minjin Jeong, Karen E. Ocwieja, Dongjun Han, P. Ashley Wackym, Yichen Zhang, Alyssa Brown, Cynthia Moncada, Andrea Vambutas, Theodore Kanne, Rachel Crain, Noah Siegel, Valerie Leger, Felipe Santos, D. Bradley Welling, Lee Gehrke, Konstantina M. Stankovic   +15 more
doaj   +1 more source

Biomaterial-based drug delivery systems in the treatment of inner ear disorders

Journal of Nanobiotechnology
Inner ear disorders are among the predominant etiology of hearing loss. The blood-labyrinth barrier limits the ability of drugs to attain pharmacologically effective concentrations within the inner ear; consequently, delivering drugs systemically is ...
Hong Cheng, Bin Zhang, Pei Jiang, Menghui Liao, Xin Gao, Dongyu Xu, Yusong Wang, Yangnan Hu, Huan Wang, Tingting Liu, Renjie Chai   +10 more
doaj   +1 more source

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear.
Adele Moatti, Adele Moatti, Shannon Connard, Shannon Connard, Novietta De Britto, Novietta De Britto, William A. Dunn, Srishti Rastogi, Mani Rai, Mani Rai, Lauren V. Schnabel, Lauren V. Schnabel, Frances S. Ligler, Kendall A. Hutson, Douglas C. Fitzpatrick, Alec Salt, Carlton J. Zdanski, Alon Greenbaum, Alon Greenbaum   +18 more
doaj   +1 more source

WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro

Cells, 2022
Hearing loss affects over 460 million people worldwide and is a major socioeconomic burden. Both genetic and environmental factors (i.e., noise overexposure, ototoxic drug treatment and ageing), promote the irreversible degeneration of cochlear hair ...
Francis Rousset, Giulia Schilardi, Stéphanie Sgroi, German Nacher-Soler, Rebecca Sipione, Sonja Kleinlogel, Pascal Senn   +6 more
doaj   +1 more source

Probing the Xenopus laevis inner ear transcriptome for biological function

BMC Genomics, 2012
Background The senses of hearing and balance depend upon mechanoreception, a process that originates in the inner ear and shares features across species.
Powers TuShun R, Virk Selene M, Trujillo-Provencio Casilda, Serrano Elba E   +3 more
doaj   +1 more source

The Frog Inner Ear: Picture Perfect? [PDF]

Journal of the Association for Research in Otolaryngology, 2015
Many recent accounts of the frog peripheral auditory system have reproduced Wever's (1973) schematic cross-section of the ear of a leopard frog. We sought to investigate to what extent this diagram is an accurate and representative depiction of the anuran inner ear, using three-dimensional reconstructions made from serial sections of Rana pipiens ...
Mason, Matthew J., Segenhout, Johannes M., Cobo-Cuan, Ariadna, Quiones, Patricia M., van Dijk, Pim   +4 more
openaire   +2 more sources

Role of Dach1 revealed using a novel inner ear-specific Dach1-knockdown mouse model

Biology Open, 2019
The Dach1 gene is expressed in the inner ear of normal mouse embryos in the area that differentiates into the cochlear stria vascularis (SV). We hypothesised that Dach1 downregulation in the inner ear would lead to SV dysplasia.
Toru Miwa, Ryosei Minoda, Yoshihide Ishikawa, Tomohito Kajii, Yorihisa Orita, Takahiro Ohyama   +5 more
doaj   +1 more source

Inner ear organoids: Recent progress and potential applications

Fundamental Research
The inner ear is one of the most complicated structures that harbor organs for the perception of sound and balance, which is deep in the temporal bone and challenging to operate.
Yiyun Lou, Yaoqian Liu, Mingxuan Wu, Gaogan Jia, Mingyu Xia, Wenyan Li   +5 more
doaj   +1 more source

Inner Ear Therapeutics: An Overview of Middle Ear Delivery

Frontiers in Cellular Neuroscience, 2019
There are a variety of methods to access the inner ear and many of these methods depend on utilizing the middle ear as a portal. In this approach the middle ear can be used as a passive receptacle, as part of an active drug delivery system, or simply as ...
Jaimin Patel, Mikhaylo Szczupak, Suhrud Rajguru, Suhrud Rajguru, Carey Balaban, Michael E. Hoffer, Michael E. Hoffer   +6 more
doaj   +1 more source