Results 41 to 50 of about 80,529 (260)

Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss

Frontiers in Pharmacology, 2014
Sensorineural hearing loss (SNHL) is a common clinical condition resulting from dysfunction in one or more parts in the auditory pathway between the inner ear and auditory cortex.
Takayuki eOkano
doaj   +1 more source

NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss

Frontiers in Cell and Developmental Biology, 2022
The reactive oxygen species (ROS)-generating NADPH oxidase NOX3 isoform is highly and specifically expressed in the inner ear. NOX3 is needed for normal vestibular development but NOX-derived ROS have also been implicated in the pathophysiology of ...
Francis Rousset, German Nacher-Soler, Vivianne Beatrix Christina Kokje, Vivianne Beatrix Christina Kokje, Stéphanie Sgroi, Marta Coelho, Karl-Heinz Krause, Pascal Senn, Pascal Senn   +8 more
doaj   +1 more source

Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography [PDF]

Clinical and Experimental Otorhinolaryngology, 2020
Objectives This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic ...
Se-Joon Oh, Il-Woo Lee, Soo-Geun Wang, Soo-Keun Kong, Hong-Ki Kim, Eui-Kyung Goh   +5 more
doaj   +1 more source

Shape Memory Microneedle to Prevent Risks of Reproductive Hormone Therapy by Switching Sustained to Burst Release Under a Single Transdermal Insertion

Advanced Functional Materials, EarlyView.
A shape‐memory microneedle system enables reproductive hormone therapy through a single transdermal insertion. The X‐shaped device sustains follicle‐stimulating hormone release for three days, and mild heating restores the O shape to trigger burst human chorionic gonadotropin release.
Sungwoo Cho, Hyunjae Kim, Seung Eun Yu, Sangmin Lee, Ji Youn Lee, Mi‐Lan Kang, Kang Suk Lee, Young Sik Choi, Hak‐Joon Sung   +8 more
wiley   +1 more source

Assessment of drug permeability through an ex vivo porcine round window membrane model

iScience, 2023
Summary: Delivery of pharmaceutical therapeutics to the inner ear to treat and prevent hearing loss is challenging. Systemic delivery is not effective as only a small fraction of the therapeutic agent reaches the inner ear.
Adele Moatti, Dylan Silkstone, Taylor Martin, Keith Abbey, Kendall A Hutson, Douglas C Fitzpatrick, Carlton J Zdanski, Alan G Cheng, Frances S Ligler, Alon Greenbaum   +9 more
doaj   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

EARLY STEPS IN INNER EAR DEVELOPMENT: INDUCTION AND MORPHOGENESIS OF THE OTIC PLACODE

Frontiers in Pharmacology, 2015
Various cellular replacement therapies using in vitro generated cells to replace damaged tissue have been proposed as strategies to alleviate hearing loss.
Xaiorei eSai, Raj K. Ladher
doaj   +1 more source

Application of Nanomedicine in Inner Ear Diseases

Frontiers in Bioengineering and Biotechnology, 2022
The treatment of inner ear disorders always remains a challenge for researchers. The presence of various physiological barriers, primarily the blood–labyrinth barrier (BLB), limits the accessibility of the inner ear and hinders the efficacy of various ...
Qianyu Lin, Qianyu Lin, Qiong Guo, Qiong Guo, Mingchao Zhu, Juanli Zhang, Bei Chen, Tingting Wu, Tingting Wu, Wei Jiang, Wei Jiang, Wenxue Tang, Wenxue Tang   +12 more
doaj   +1 more source

Microsphere‐Templated Conductive Syntactic Foams for Recyclable and Additively Manufactured Soft Electronics

Advanced Healthcare Materials, EarlyView.
This work introduces a microsphere‐templated strategy to fabricate reprocessable PEDOT:PSS syntactic foams with tunable porosity, stable conductivity, and 3D printability. In situ PEDOT:PSS coatings create a conductive network that maintains electrical performance at high void fractions.
Gayaneh Petrossian, Yassine Diouri, Bolan Xu, Sara Ebrahimi, Atharva Pande, Floriane Miquet‐Westphal, Hang Xu, Fabio Cicoira   +7 more
wiley   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source