Results 31 to 40 of about 80,529 (260)

Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration

Nanoscale Research Letters, 2017
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration.
Jing Zou, Hao Feng, Rohit Sood, Paavo K. J. Kinnunen, Ilmari Pyykko   +4 more
doaj   +1 more source

Autophagy in the Vertebrate Inner Ear [PDF]

Frontiers in Cell and Developmental Biology, 2017
Autophagy is a conserved catabolic process that results in the lysosomal degradation of cell components. During development, autophagy is associated with tissue and organ remodeling, and under physiological conditions it is tightly regulated as it plays a housekeeping role in removing misfolded proteins and damaged organelles.
Marta Magariños, Marta Magariños, Marta Magariños, Sara Pulido, Sara Pulido, María R. Aburto, Rocío de Iriarte Rodríguez, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto   +9 more
openaire   +5 more sources

Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium

Journal of Nanobiotechnology, 2010
Background Treatment of inner ear diseases remains a problem because of limited passage through the blood-inner ear barriers and lack of control with the delivery of treatment agents by intravenous or oral administration. As a minimally-invasive approach,
Kinnunen Paavo KJ, Ramadan Usama A, Poe Dennis, Ranjan Sanjeev, Sood Rohit, Zou Jing, Pyykkö Ilmari   +6 more
doaj   +1 more source

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance

Molecules, 2018
The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies.
Sho Kanzaki
doaj   +1 more source

Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult

Frontiers in Neurology, 2021
The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves.
Jean-Paul Bryant, Vikram Chandrashekhar, Vikram Chandrashekhar, Anthony J. Cappadona, Pashayar P. Lookian, Pashayar P. Lookian, Vibhu Chandrashekhar, Danielle R. Donahue, Jeeva B. Munasinghe, H. Jeffrey Kim, H. Jeffrey Kim, Alexander O. Vortmeyer, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum, Jared S. Rosenblum   +15 more
doaj   +1 more source

Precision medicine: a new era for inner ear diseases

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +1 more source

Macrophage-related immune responses in inner ear: a potential therapeutic target for sensorineural hearing loss

Frontiers in Neuroscience
Hearing loss is the most common sensory disorder in human beings. Cochlear sensory cells are the basis of hearing. Cochlear sensory cells suffer from various acute or chronic injuries, such as excessive sound stimulation, ototoxic drugs, and age-related ...
Yu-Chen Liu, Kai Xu
doaj   +1 more source

Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear Anomalies

Balkan Medical Journal, 2019
Inner ear anomalies diagnosed using a radiological study are detected in almost 30% of cases with congenital or prelingual-onset sensorineural hearing loss.
Emre Ocak, Duygu Duman, Mustafa Tekin
doaj   +1 more source

Generation of Vestibular Tissue-Like Organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System

Frontiers in Cell and Developmental Biology, 2019
Hair cells are specialized mechanosensitive cells responsible for mediating balance and hearing within the inner ear. In mammals, hair cells are limited in number and do not regenerate.
Cristiana Mattei, Cristiana Mattei, Rebecca Lim, Hannah Drury, Babak Nasr, Babak Nasr, Babak Nasr, Zihui Li, Melissa A. Tadros, Giovanna M. D'Abaco, Kathryn S. Stok, Bryony A. Nayagam, Mirella Dottori, Mirella Dottori, Mirella Dottori   +14 more
doaj   +1 more source

Otitis media impacts hundreds of mouse middle and inner ear genes. [PDF]

PLoS ONE, 2013
Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken.
Carol J MacArthur, Fran Hausman, J Beth Kempton, Dongseok Choi, Dennis R Trune   +4 more
doaj   +1 more source