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Precision medicine: a new era for inner ear diseases
Frontiers in PharmacologyThe inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani +8 more
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Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear Anomalies
Balkan Medical Journal, 2019 Inner ear anomalies diagnosed using a radiological study are detected in almost 30% of cases with congenital or prelingual-onset sensorineural hearing loss.
Emre Ocak, Duygu Duman, Mustafa Tekin
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NADPH Oxidase 3 Deficiency Protects From Noise-Induced Sensorineural Hearing Loss
Frontiers in Cell and Developmental Biology, 2022 The reactive oxygen species (ROS)-generating NADPH oxidase NOX3 isoform is highly and specifically expressed in the inner ear. NOX3 is needed for normal vestibular development but NOX-derived ROS have also been implicated in the pathophysiology of ...
Francis Rousset +8 more
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Frontiers in NeuroscienceHearing loss is the most common sensory disorder in human beings. Cochlear sensory cells are the basis of hearing. Cochlear sensory cells suffer from various acute or chronic injuries, such as excessive sound stimulation, ototoxic drugs, and age-related ...
Yu-Chen Liu, Kai Xu
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Frontiers in Cell and Developmental Biology, 2019 Hair cells are specialized mechanosensitive cells responsible for mediating balance and hearing within the inner ear. In mammals, hair cells are limited in number and do not regenerate.
Cristiana Mattei +14 more
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Otitis media impacts hundreds of mouse middle and inner ear genes. [PDF]
PLoS ONE, 2013 Otitis media is known to alter expression of cytokine and other genes in the mouse middle ear and inner ear. However, whole mouse genome studies of gene expression in otitis media have not previously been undertaken.
Carol J MacArthur +4 more
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Extratympanic Observation of Middle and Inner Ear Structures in Rodents Using Optical Coherence Tomography [PDF]
Clinical and Experimental Otorhinolaryngology, 2020 Objectives This study aimed to investigate whether optical coherence tomography (OCT) provides useful information about the microstructures of the middle and inner ear via extratympanic approach and thereby could be utilized as an alternative diagnostic ...
Se-Joon Oh +5 more
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Inner ear‐specific autoantibodies [PDF]
The Laryngoscope, 1993 AbstractThe sera of patients with idiopathic sensorineural hearing loss (SNHL) were examined, using qualitative immunoblotting (Western blotting), for the presence of inner ear (IE)‐specific autoantibodies. The water‐soluble extracts and the sodium dodecyl sulfate‐soluble extracts were prepared as the antigens from bovine IE tissues and several other ...
S, Yamanobe, J P, Harris
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Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression [PDF]
, 2015 In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages of chick inner ear formation.
Acloque +53 more
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Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss
Frontiers in Pharmacology, 2014 Sensorineural hearing loss (SNHL) is a common clinical condition resulting from dysfunction in one or more parts in the auditory pathway between the inner ear and auditory cortex.
Takayuki eOkano
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