Results 31 to 40 of about 874,948 (295)

Nanoparticles in Inner Ear Diseases

National Board of Examinations Journal of Medical Sciences, 2023
Nanoparticles are novel discoveries which hold a promising role for delivering medications into the inner ear in the future. Nanoparticles are formed by the preparation of different biomaterials.
Soumick Ranjan Sahoo
doaj   +1 more source

Molecular biology of hearing [PDF]

, 2012
The inner ear is our most sensitive sensory organ and can be subdivided into three functional units: organ of Corti, stria vascularis and spiral ganglion.
Diensthuber, M, Stöver, T, Diensthuber, Marc, Stöver, Timo   +3 more
core   +1 more source

Potential application value of pigment epithelium-derived factor in sensorineural hearing loss

Frontiers in Neuroscience, 2023
The inner ear is a complex and precise auditory perception system responsible for receiving and converting sound signals into neural signals, enabling us to perceive and understand sound.
Zihui Sun, Zihui Sun, Xiaoguang Li, Xiaoguang Li, Guangfei Li, Guangfei Li, Ying Xu, Jie Meng, Jie Meng, Wei Meng, Wei Meng, Shuangba He, Shuangba He   +12 more
doaj   +1 more source

Autophagy in the Vertebrate Inner Ear [PDF]

Frontiers in Cell and Developmental Biology, 2017
Autophagy is a conserved catabolic process that results in the lysosomal degradation of cell components. During development, autophagy is associated with tissue and organ remodeling, and under physiological conditions it is tightly regulated as it plays a housekeeping role in removing misfolded proteins and damaged organelles.
Marta Magariños, Marta Magariños, Marta Magariños, Sara Pulido, Sara Pulido, María R. Aburto, Rocío de Iriarte Rodríguez, Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto   +9 more
openaire   +5 more sources

RAF kinase activity regulates neuroepithelial cell proliferation and neuronal progenitor cell differentiation during early inner ear development [PDF]

, 2010
Background: Early inner ear development requires the strict regulation of cell proliferation, survival, migration and differentiation, coordinated by the concerted action of extrinsic and intrinsic factors.
Rapp Ulf R., Marta Magariños, Varela-Nieto, Isabel, Hortensia Sánchez-Calderón, Aburto María R., Muñoz-Agudo, Carmen, Muñoz-Agudo Carmen, Rapp, Ulf Rüdiger, Rodriguez Aburto, Maria, María R. Aburto, Magariños Marta, María R Aburto, Sánchez-Calderón, Hortensia, Rapp, Ulf R., Ulf R Rapp, Isabel Varela-Nieto, Varela-Nieto Isabel, Magariños, Marta, Carmen Muñoz-Agudo, Sánchez-Calderón Hortensia, Ulf R. Rapp, Muñoz Agudo, Carmen   +21 more
core   +2 more sources

Biocompatibility of Liposome Nanocarriers in the Rat Inner Ear After Intratympanic Administration

Nanoscale Research Letters, 2017
Liposome nanocarriers (LPNs) are potentially the future of inner ear therapy due to their high drug loading capacity and efficient uptake in the inner ear after a minimally invasive intratympanic administration.
Jing Zou, Hao Feng, Rohit Sood, Paavo K. J. Kinnunen, Ilmari Pyykko   +4 more
doaj   +1 more source

Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium

Journal of Nanobiotechnology, 2010
Background Treatment of inner ear diseases remains a problem because of limited passage through the blood-inner ear barriers and lack of control with the delivery of treatment agents by intravenous or oral administration. As a minimally-invasive approach,
Kinnunen Paavo KJ, Ramadan Usama A, Poe Dennis, Ranjan Sanjeev, Sood Rohit, Zou Jing, Pyykkö Ilmari   +6 more
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Characterizing human vestibular sensory epithelia for experimental studies: new hair bundles on old tissue and implications for therapeutic interventions in ageing. [PDF]

, 2015
Balance disequilibrium is a significant contributor to falls in the elderly. The most common cause of balance dysfunction is loss of sensory cells from the vestibular sensory epithelia of the inner ear.
Daniel J. Jagger, Moffatt, D, Jagger, DJ, Peter Monksfield, Donnelly, N, Lloyd, SK, Irving, R, Coulson, C, Freeman, SR, Richard Irving, Simon K. Lloyd, Neil Donnelly, Shakeel R. Saeed, Taylor, RR, David Moffatt, Forge, A, Saeed, SR, Axon, P, Ruth R. Taylor, Monksfield, P, Simon R. Freeman, Chris Coulson, Tysome, J, Andrew Forge, Patrick Axon, James Tysome   +25 more
core   +1 more source

Gene Delivery into the Inner Ear and Its Clinical Implications for Hearing and Balance

Molecules, 2018
The inner ear contains many types of cell, including sensory hair cells and neurons. If these cells are damaged, they do not regenerate. Inner ear disorders have various etiologies.
Sho Kanzaki
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Next-generation 3D bioprinted inner ear organoids

Biomedical Technology
Background: Inner ear is crucial for maintaining normal functions of human sensory perception. However, current perceptual reconstruction is mostly limited to symptomatic relief and lacks a radical cure for irreversible damage.
Xingyu Chen, Minghong He, Yuexin He, Zhe Li, Renjie Chai   +4 more
doaj   +1 more source