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Numb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear. [PDF]
, 2015 The Notch signaling pathway controls differentiation of hair cells and supporting cells in the vertebrate inner ear. Here, we have investigated whether Numb, a known regulator of Notch activity in Drosophila, is involved in this process in the embryonic ...
Mark eEddison +14 more
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Genetic Causes of Sensorineural Hearing Loss Associated with Inner Ear Malformations
, 2022 Clinically significant hearing loss is present in ~1 per 500 newborns and affects more than 30% of the population at some time in their lives. Empowered by the astounding progress in DNA sequencing technology, recent studies have brought the number of ...
Tekin, Mustafa +7 more
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Proteomics and the Inner Ear [PDF]
Disease Markers, 2001 The inner ear, one of the most complex organs, contains within its bony shell three sensory systems, the evolutionary oldest gravity receptor system, the three semicircular canals for the detection of angular acceleration, and the auditory system ‐ unrivaled in sensitivity and frequency discrimination.
openaire +2 more sources
Inner ear barriers to nanomedicine-augmented drug delivery and imaging
Journal of Otology, 2016 There are several challenges to inner ear drug delivery and imaging due to the existence of tight biological barriers to the target structure and the dense bone surrounding it. Advances in imaging and nanomedicine may provide knowledge for overcoming the
Jing Zou, Ilmari Pyykkö, Jari Hyttinen
doaj +1 more source
Diagnostics, 2020 The diagnostics of inner ear diseases are primarily functional, but there is a growing interest in inner ear biomarkers. The present scoping review aimed to elucidate gaps in the literature regarding the definition, classification system, and an overview
Nahla A. Gomaa +4 more
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American Journal of Otolaryngology, 1985 Previously the authors proposed that the perilymphatic inner ear immune system is independent of that of the cerebrospinal fluid. In the present study, the effect of dilatation of blood vessels surrounding the cochlea of chinchillas on the transfer of serum antibodies to the perilymph was tested. The possibility of local production of antibodies in the
Kawauchi, H. +3 more
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Congenital Inner Ear Abnormalities and COVID-19-Related Ear Infections
Ear, Nose & Throat Journal, 2022 Congenital deformities of the labyrinth of the inner ear may be associated with an increased risk of infection and varying degrees of otologic and vestibular dysfunction. Lateral semicircular canal abnormalities specifically can be associated with either
Shivesh Maharaj MBBCH, MMED, FCORL +1 more
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Biomedicines, 2021 Zebrafish is an excellent model for exploring the development of the inner ear. Its inner ear has similar functions to that of humans, specifically in the maintenance of hearing and balance. Mafba is a component of the Maf transcription factor family. It
Xiang Chen +10 more
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Visualization of macrophage subsets in the development of the fetal human inner ear
Frontiers in Immunology, 2022 BackgroundHuman inner ear contains macrophages whose functional role in early development is yet unclear. Recent studies describe inner ear macrophages act as effector cells of the innate immune system and are often activated following acoustic trauma or
Claudia Steinacher +11 more
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Inner ear tissue preservation by rapid freezing: Improving fixation by high-pressure freezing and hybrid methods. [PDF]
, 2014 In the preservation of tissues in as 'close to life' state as possible, rapid freeze fixation has many benefits over conventional chemical fixation. One technique by which rapid freeze-fixation can be achieved, high pressure freezing (HPF), has been ...
Taylor, R.R. +11 more
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