Results 51 to 60 of about 447,391 (302)

EARLY STEPS IN INNER EAR DEVELOPMENT: INDUCTION AND MORPHOGENESIS OF THE OTIC PLACODE

Frontiers in Pharmacology, 2015
Various cellular replacement therapies using in vitro generated cells to replace damaged tissue have been proposed as strategies to alleviate hearing loss.
Xaiorei eSai, Raj K. Ladher
doaj   +1 more source

Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction

Communications Medicine, 2021
Plain language summary Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the novel coronavirus SARS-CoV-2. A growing number of sensory symptoms have been linked to this illness.
Minjin Jeong, Karen E. Ocwieja, Dongjun Han, P. Ashley Wackym, Yichen Zhang, Alyssa Brown, Cynthia Moncada, Andrea Vambutas, Theodore Kanne, Rachel Crain, Noah Siegel, Valerie Leger, Felipe Santos, D. Bradley Welling, Lee Gehrke, Konstantina M. Stankovic   +15 more
doaj   +1 more source

WNT Activation and TGFβ-Smad Inhibition Potentiate Stemness of Mammalian Auditory Neuroprogenitors for High-Throughput Generation of Functional Auditory Neurons In Vitro

Cells, 2022
Hearing loss affects over 460 million people worldwide and is a major socioeconomic burden. Both genetic and environmental factors (i.e., noise overexposure, ototoxic drug treatment and ageing), promote the irreversible degeneration of cochlear hair ...
Francis Rousset, Giulia Schilardi, Stéphanie Sgroi, German Nacher-Soler, Rebecca Sipione, Sonja Kleinlogel, Pascal Senn   +6 more
doaj   +1 more source

Hearing loss in Takayasu's arteritis: a role for hyperbaric oxygen therapy? [PDF]

, 2017
In the scientific community, there is growing interest regarding associated symptoms in Takayasu’s arteritis (TA), an autoimmune condition that mainly affects the medium and large arteries.
de Vincentiis, Marco, Greco, Antonio, Ralli, Massimo   +2 more
core   +1 more source

FeDSNP‐Pa Nanoassemblies: A Triple‐Action Therapeutic Strategy Targeting Oxidative Stress, Inflammation, and Pyroptosis for Retinal Ganglion Cell Protection in Glaucoma

Advanced Functional Materials, EarlyView.
FeDSNP‐Pa, a metallized nanoparticle loaded with sodium pyruvate (Pa), exerts triple therapeutic effects by scavenging reactive oxygen species (ROS), suppressing inflammatory responses, and inhibiting pyroptosis signaling pathways. This multifunctional neuroprotective strategy protecting retinal ganglion cells (RGCs) from elevated intraocular pressure ...
Yukun Wu, Xue Li, Tong Wu, Dan Ji, Yugang Bai, Xuezhi Zhou   +5 more
wiley   +1 more source

Polymer‐Incorporated Mechanically Compliant Carbon Nanotube Microelectrode Arrays for Multichannel Neural Signal Recording

Advanced Functional Materials, EarlyView.
This work presents a soft microelectrode array based on vertically aligned carbon nanotube (CNT) forests, combining high conductivity with mechanical softness. A densification process and air‐pressure‐assisted flexibilization improve structural integrity, ensuring stable insertion and reduced inflammation.
Hyeonhee Roh, Kwangjun Kim, Chaesung Kim, Minju Kim, Minwook Kim, Sangjun Sim, Jongbaeg Kim, Jong G. Ok, Maesoon Im   +8 more
wiley   +1 more source

Surgical procedure of intratympanic injection and inner ear pharmacokinetics simulation in domestic pigs

Frontiers in Pharmacology
Introduction: One major obstacle in validating drugs for the treatment or prevention of hearing loss is the limited data available on the distribution and concentration of drugs in the human inner ear.
Adele Moatti, Adele Moatti, Shannon Connard, Shannon Connard, Novietta De Britto, Novietta De Britto, William A. Dunn, Srishti Rastogi, Mani Rai, Mani Rai, Lauren V. Schnabel, Lauren V. Schnabel, Frances S. Ligler, Kendall A. Hutson, Douglas C. Fitzpatrick, Alec Salt, Carlton J. Zdanski, Alon Greenbaum, Alon Greenbaum   +18 more
doaj   +1 more source

Probing the Xenopus laevis inner ear transcriptome for biological function

BMC Genomics, 2012
Background The senses of hearing and balance depend upon mechanoreception, a process that originates in the inner ear and shares features across species.
Powers TuShun R, Virk Selene M, Trujillo-Provencio Casilda, Serrano Elba E   +3 more
doaj   +1 more source

Which GABA Receptors Are Expressed in the Zebrafish Lateral Line? [PDF]

, 2017
The presence of the neurotransmitter GABA in the mammalian inner ear is well established, yet its role in regulating inner ear cell function is less clear.
Crabtree, Connell, Hayes, Kyler, Ikenaga, Jaren, Schwehr, Megan, Toro, Cecilia, Yangchen, Tenzin   +5 more
core   +1 more source

Inner ear ossification and mineralization kinetics in human embryonic development - microtomographic and histomorphological study. [PDF]

, 2017
Little is known about middle and inner ear development during the second and third parts of human fetal life. Using ultra-high resolution Microcomputed Tomography coupled with bone histology, we performed the first quantitative middle and inner ear ...
Courbon, G., Laroche, N., Malaval, L., Prades, J.M., Richard, C., Vico, L.   +5 more
core   +1 more source