Results 51 to 60 of about 1,559,915 (394)

Inner ear delivery: Challenges and opportunities

Laryngoscope Investigative Otolaryngology, 2019
The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future ...
Betsy Szeto, H. Chiang, Chris Valentini, Michelle Yu, J. Kysar, A. Lalwani   +5 more
semanticscholar   +1 more source

Classification and Current Management of Inner Ear Malformations

Balkan Medical Journal, 2017
Morphologically congenital sensorineural hearing loss can be investigated under two categories. The majority of congenital hearing loss causes (80%) are membranous malformations. Here, the pathology involves inner ear hair cells.
L. Sennaroğlu, Münir Demir Bajin
semanticscholar   +1 more source

Round window membrane and delivery of biologically active agents into the cochlea [PDF]

, 2010
Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue.
Saber, Amanj K.
core   +1 more source

Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression [PDF]

, 2015
In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages of chick inner ear formation.
Acloque, Ailín L. Buzzi, Alvarez, Baker, Barald, Barembaum, Beyer, Bokoch, Borges, Bradnam, Brown, Brown, Campanero, Chen, Cheng, Christophorou, Cobos, Couture, Deitcher, Driver, Dutton, Emmett, Fodor, Gerchman, Govek, Groves, Hans, Hofmann, Kalari, Kawazu, Lee, Li, Liu, Luo, Majewski, Marianne E. Bronner, Martin, Moro-Balbás, Neves, Pablo H. Strobl-Mazzulla, Park, Represa, Rosa A. Uribe, Sai, Sai, Siegfried, Sims, Stevens, Streit, Strobl-Mazzulla, Tan, Theveneau, Van Kerschaver, Visconti   +53 more
core   +3 more sources

Genetic Causes of Inner Ear Anomalies: a Review from the Turkish Study Group for Inner Ear Anomalies

Balkan Medical Journal, 2019
Inner ear anomalies diagnosed using a radiological study are detected in almost 30% of cases with congenital or prelingual-onset sensorineural hearing loss.
Emre Ocak, Duygu Duman, Mustafa Tekin
doaj   +1 more source

Multimodal Atlas of the Murine Inner Ear: From Embryo to Adult

Frontiers in Neurology, 2021
The inner ear is a complex organ housed within the petrous bone of the skull. Its intimate relationship with the brain enables the transmission of auditory and vestibular signals via cranial nerves.
Jean-Paul Bryant, Vikram Chandrashekhar, Vikram Chandrashekhar, Anthony J. Cappadona, Pashayar P. Lookian, Pashayar P. Lookian, Vibhu Chandrashekhar, Danielle R. Donahue, Jeeva B. Munasinghe, H. Jeffrey Kim, H. Jeffrey Kim, Alexander O. Vortmeyer, John D. Heiss, Zhengping Zhuang, Jared S. Rosenblum, Jared S. Rosenblum   +15 more
doaj   +1 more source

Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities

Artificial Cells Nanomedicine and Biotechnology, 2019
Hearing loss is the most common neurosensory impairment worldwide. While conductive hearing loss can be managed by surgery, the management of sensorineural hearing loss (SNHL), related to the damage of sensory cells of the inner ear is more challenging ...
R. Mittal, Stefanie Pena, Angela Zhu, Nicolas Eshraghi, Arian Fesharaki, E. Horesh, Jeenu Mittal, A. Eshraghi   +7 more
semanticscholar   +1 more source

Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]

, 2017
open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura, Chicca, Milvia, DANTI, SERENA, Franceschini, Valeria, Martini, Alessandro, Simoni, Edi, Valente, Filippo   +6 more
core   +2 more sources

Precision medicine: a new era for inner ear diseases

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +1 more source

Generation of Vestibular Tissue-Like Organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System

Frontiers in Cell and Developmental Biology, 2019
Hair cells are specialized mechanosensitive cells responsible for mediating balance and hearing within the inner ear. In mammals, hair cells are limited in number and do not regenerate.
Cristiana Mattei, Cristiana Mattei, Rebecca Lim, Hannah Drury, Babak Nasr, Babak Nasr, Babak Nasr, Zihui Li, Melissa A. Tadros, Giovanna M. D'Abaco, Kathryn S. Stok, Bryony A. Nayagam, Mirella Dottori, Mirella Dottori, Mirella Dottori   +14 more
doaj   +1 more source