Results 241 to 250 of about 307,971 (276)

Destination: inner nuclear membrane

Trends in Cell Biology, 2014
The inner nuclear membrane (INM) of eukaryotic cells is enriched in proteins that are required for nuclear structure, chromosome organization, DNA repair, and transcriptional control. Mislocalization of INM proteins is observed in a wide spectrum of human diseases; however, the mechanism by which INM proteins reach their final destination is poorly ...
Santharam S, Katta, Christine J, Smoyer, Sue L, Jaspersen   +2 more
openaire   +2 more sources

Inner nuclear membrane proteins: functions and targeting

Cellular and Molecular Life Sciences, 2001
We summarize the properties of integral membrane proteins that reside in the inner nuclear membrane, including lamin B receptor (LBR), lamina-associated polypeptide (LAP) 1, LAP2, emerin, MAN1 and nurim. Most of these proteins interact with lamins and chromatin.
L, Holmer, H J, Worman
openaire   +2 more sources

Inner nuclear membrane proteins: impact on human disease

Chromosoma, 2012
In the past decade, the inner nuclear membrane has become a focus of research on inherited diseases. A heterogeneous group of genetic disorders known as laminopathies have been described that result from mutations in genes encoding nuclear lamins, intermediate filament proteins associated with the inner nuclear membrane.
Iván, Méndez-López, Howard J, Worman
openaire   +2 more sources

A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis

Journal of Cell Science, 2022
AbstractAberrant accumulation of inner nuclear membrane (INM) proteins is associated with deformed nuclear morphology and mammalian diseases. However, the mechanisms underlying the maintenance of INM homeostasis remain poorly understood.
Toan Khanh Le, Yasuhiro Hirano, Haruhiko Asakawa, Koji Okamoto, Tatsuo Fukagawa, Tokuko Haraguchi, Yasushi Hiraoka   +6 more
openaire   +2 more sources

Inner nuclear membrane and signal transduction

Journal of Cellular Biochemistry, 2005
AbstractRecent research has shown that the inner nuclear membrane is a site for regulation of signal transduction from the plasma membrane to the nucleus. This has coincided with discoveries showing that mutations in extrinsic and intrinsic inner nuclear membrane proteins cause a variety of inherited diseases. In most instances, the mechanisms by which
openaire   +2 more sources

Inner nuclear membrane proteins and the nuclear lamina

Journal of Cell Science, 2001
The nuclear lamina is a scaffolding structure at the nuclear periphery and is required for maintenance of nuclear shape, spacing of nuclear pore complexes, organization of heterochromatin, DNA replication, and regulation of transcription factors.
openaire   +2 more sources

Karyopherin-mediated import of integral inner nuclear membrane proteins

Nature, 2006
Targeting of newly synthesized integral membrane proteins to the appropriate cellular compartment is specified by discrete sequence elements, many of which have been well characterized. An understanding of the signals required to direct integral membrane proteins to the inner nuclear membrane (INM) remains a notable exception.
Megan C, King, C Patrick, Lusk, Günter, Blobel   +2 more
openaire   +2 more sources

Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane.

Current Opinion in Cell Biology, 2015
The inner nuclear membrane (INM) represents a specialized subdomain of the endoplasmic reticulum (ER). The INM houses a unique set of integral membrane proteins that perform key functions in the organization of intranuclear architecture, control of gene expression and coupling of the nucleus to the cytoskeleton.
Rosemarie Ungricht, U. Kutay
semanticscholar   +3 more sources

Inner nuclear membrane and regulation of Smad-mediated signaling

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006
Smads mediate signal transduction by cytokines of the transforming growth factor-beta family. Recent data show that intrinsic and extrinsic proteins of the inner nuclear membrane affect the activities of Smads. MAN1, an integral protein of the inner nuclear membrane, binds to receptor-regulated Smads and antagonizes signaling by transforming growth ...
openaire   +2 more sources

Inner Nuclear Layer Thickness, a Biomarker of Metamorphopsia in Epiretinal Membrane, Correlates With Tangential Retinal Displacement.

American journal of ophthalmology-glaucoma, 2018
PURPOSE To examine correlations of inner nuclear layer (INL) thickness with metamorphopsia and tangential retinal displacement in epiretinal membrane (ERM). DESIGN Retrospective, consecutive, interventional case series. METHODS Setting: Institutional
Y. Ichikawa, Y. Imamura, M. Ishida
semanticscholar   +1 more source