Results 41 to 50 of about 138,845 (243)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The impact of enterprises’ scientific capabilities on innovation performance: evidence from an empirical analysis and simulation model

Humanities & Social Sciences Communications
As the interaction between science and technology intensifies, the role of science in driving technological innovation has become increasingly significant.
Weijie Zhu, Wucheng Han, Ruoyu Lu, Jiasu Lei   +3 more
doaj   +1 more source

Capabilities and innovation enablers of the value proposition of actors in platform businesses [PDF]

مطالعات مدیریت راهبردی
IntroductionThe emergence of digital platforms is increasing as a result of technology development [4]. Although organizations consider digital platforms as a very important way to achieve technological innovation, the platform companies themselves also ...
Maryam Nematollahi Sarvestani, Masoumeh Hosseinzadeh Shahri, Mohammad Ali Babaie Zakliki   +2 more
doaj   +1 more source

Development of Dynamic Capabilities for Automotive Industry Performance under Disruptive Innovation

Journal of Open Innovation: Technology, Market and Complexity, 2020
Dynamic capabilities are creating dramatic change for the industry around the world. Resource-Based View (RBV) theory and Operational capability theory are the basic capabilities of an organization under a normal changing environment.
Atichat Rotjanakorn, Pornrat Sadangharn, Khahan Na-Nan   +2 more
doaj   +1 more source

New business model of integration practices between TQM and SCM: the role of innovation capabilities [PDF]

Problems and Perspectives in Management, 2019
The concept of “total quality management (TQM)” is broadly used in business. Regardless of the fact that several studies have analyzed this topic, little research has been conducted on integrating total quality management and supply chain management (SCM)
Hana Arrfou
doaj   +1 more source

The consequences of innovation failure: An innovation capabilities and dynamic capabilities perspective

Technovation, 2023
Organizations engage with innovation by leveraging their innovation capabilities and dynamic capabilities. In this study, we examined how organizational innovation capabilities and dynamic capabilities can influence organizational performance, taking into account cases when innovation projects do not yield beneficial outcomes to organizations. Building
Chatterjee S., Chaudhuri R., Mariani M., Fosso Wamba S.   +3 more
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Dimensions of Alignment between Digital Capability and Innovation Strategy in Petrochemical Industry [PDF]

مطالعات مدیریت کسب و کار هوشمند
The reduction of profit margins and the disappearance of past competitive advantages have pushed companies in Petrochemical industries toward innovation by utilizing digital capabilities.
Soroush Ghazinoori, Sohrab Aghazade Masroor, Mohamad Naghizadeh, Mojtaba Hajian Heidary   +3 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source