Results 61 to 70 of about 151,755 (264)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Technological capabilities: strategic component of the competitiviness
Revista Facultad de Ingeniería Universidad de Antioquia, 2005 This paper presents an explanatory model for the dynamics of the competitiveness of companies and national economies. The model is based on approaches and theories about competitiveness, as well as new theories of growth, the theory of technological ...
Heberto Tapias García
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Dimensions of Alignment between Digital Capability and Innovation Strategy in Petrochemical Industry [PDF]
مطالعات مدیریت کسب و کار هوشمندThe reduction of profit margins and the disappearance of past competitive advantages have pushed companies in Petrochemical industries toward innovation by utilizing digital capabilities.
Soroush Ghazinoori +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Capabilities and innovation enablers of the value proposition of actors in platform businesses [PDF]
مطالعات مدیریت راهبردیIntroductionThe emergence of digital platforms is increasing as a result of technology development [4]. Although organizations consider digital platforms as a very important way to achieve technological innovation, the platform companies themselves also ...
Maryam Nematollahi Sarvestani +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
CRM System: the Role of Dynamic Capabilities in creating Innovation Capability
BBR: Brazilian Business Review, 2018 Customer relationship management (CRM) is a topic discussed, mainly, by information systems and marketing management areas. Many organizations are already using CRM systems.
Cristiane Drebes Pedron +3 more
doaj +1 more source
Building management and innovation capabilities for global health: a senior executive program. [PDF]
Front Public Health, 2023 Prado AM +7 more
europepmc +1 more source