Results 81 to 90 of about 2,738,380 (292)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Dimensions of Alignment between Digital Capability and Innovation Strategy in Petrochemical Industry [PDF]

مطالعات مدیریت کسب و کار هوشمند
The reduction of profit margins and the disappearance of past competitive advantages have pushed companies in Petrochemical industries toward innovation by utilizing digital capabilities.
Soroush Ghazinoori, Sohrab Aghazade Masroor, Mohamad Naghizadeh, Mojtaba Hajian Heidary   +3 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Innovation and Economic Development [PDF]

Innovation is often seen as carried out by highly educated labour in R&D intensive companies with strong ties to leading centers of excellence in the scientific world. Seen from this angle innovation is a typical “first world” activity. There is, however,
Martin Srholec, Jan Fagerberg, Bart Verspagen   +2 more
core   +2 more sources

Building management and innovation capabilities for global health: a senior executive program. [PDF]

Front Public Health, 2023
Prado AM, Sánchez-Gómez JI, Casamitjana N, Espriu M, Kumar P, Ngoye B, Bärnighausen T, Rosenmoller M.   +7 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Fostering business model innovation for sustainability: a dynamic capabilities perspective

, 2022
PurposeThe study aimed to analyze the association between dynamic capabilities and sustainable business model innovation of startups in the Brazilian logistics sector.Design/methodology/approachA qualitative approach was used through a multiple case ...
Maffini Gomes, Clandia, Marques Kneipp, Jordana, Clandia Maffini Gomes, Schoproni Bichueti, Roberto, Diéssica Oliveira-Dias, De Oliveira Dias, Diessica, Roberto Schoproni Bichueti, Jordana Marques Kneipp   +7 more
core   +1 more source

CRM System: the Role of Dynamic Capabilities in creating Innovation Capability

BBR: Brazilian Business Review, 2018
Customer relationship management (CRM) is a topic discussed, mainly, by information systems and marketing management areas. Many organizations are already using CRM systems.
Cristiane Drebes Pedron, Winnie Ng Picoto, Miguel Colaco, Cintia Cristina Araújo   +3 more
doaj   +1 more source

Retracted: Integration of Green Innovation Capabilities of Enterprises Based on Ant Colony Optimization Algorithm. [PDF]

Comput Intell Neurosci, 2023
Intelligence And Neuroscience C.
europepmc   +1 more source