Results 121 to 130 of about 71,261 (330)

Association between prediagnostic serum metabolites and pancreatic ductal adenocarcinoma risk in two prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Exposures and mechanisms that contribute to and promote pancreatic ductal adenocarcinoma (PDAC) remain unclear. In this study, the authors applied metabolomics to better understand PDAC etiology by examining associations between prediagnostic serum metabolites and PDAC risk.
Ting Zhang, Steven C. Moore, Sheng Fu, Xiaoyu Wang, Demetrius Albanes, Stephanie J. Weinstein, Kai Yu, Rachael Z. Stolzenberg‐Solomon   +7 more
wiley   +1 more source

Gastroprotective effects of oral nucleotide administration [PDF]

, 2006
BACKGROUND AND AIMS: Nucleotides form the building blocks of DNA and are marketed as dietary supplements, alone or in combination with other ingredients, to promote general health.
Belo, A, Fitzgerald, A, Ghosh, S, Marchbank, T, Playford, RJ   +4 more
core   +2 more sources

Formation of tRNA Wobble Inosine in Humans Is Disrupted by a Millennia-Old Mutation Causing Intellectual Disability

Molecular and Cellular Biology, 2019
The formation of inosine at the wobble position of eukaryotic tRNAs is an essential modification catalyzed by the ADAT2/ADAT3 complex. In humans, a valine-to-methionine mutation (V144M) in ADAT3 that originated ∼1,600 years ago is the most common cause ...
Jillian Ramos, Lu Han, Yan Li, Felix Hagelskamp, Stefanie M. Kellner, F. Alkuraya, E. Phizicky, Dragony Fu   +7 more
semanticscholar   +1 more source

Characterization of Newly Discovered Polyester Polyurethane‐Degrading Methylobacterium aquaticum Strain A1

Journal of Basic Microbiology, EarlyView.
ABSTRACT In this study, we present Methylobacterium aquaticum A1, a novel strain capable of degrading polyester polyurethane (PE‐PUR). The attachment of M. aquaticum A1 to PE‐PUR and its degradation capabilities were verified using Scanning Electron Microscopy (SEM) and Fourier‐Transform Infrared Spectroscopy (FT‐IR).
Seong Hyeon Lee, Haemin Jeong, Injun Jung, Myounghyun Choi, Ah‐Ram Kim   +4 more
wiley   +1 more source

Preparation, Quality and Purine-lowering Activity of Functional Yak Yoghurt during Storage Period

Shipin gongye ke-ji
In order to develop a purine-reducing functional yak yoghurt, Lactobacillus paracasei 259 and commercial starter was used as the fermentation strain in this experiment.
Xindi YU, Jingya LIU, Xiumei REN, Lianhong CHEN   +3 more
doaj   +1 more source

Rationalising sequence selection by ligand assemblies in the DNA minor groove : the case for thiazotropsin A [PDF]

, 2011
DNA-sequence and structure dependence on the formation of minor groove complexes at 5′-XCTAGY-3′ by the short lexitropsin thiazotropsin A are explored based on NMR spectroscopy, isothermal titration calorimetry (ITC), circular dichroism (CD) and ...
Anthony, Anthony, Anthony, Barber, Bergqvist, Blaskó, Borea, Chaires, Chenoweth, Dervan, Dervan, Engel, Freyer, Freyer, Gottesfeld, Haq, Haq, Harris, James, Khalaf, Kwong, Ladbury, Lafont, Marques, Neidle, O'Brien, Pang, Parkinson, Pelton, Pullman, Rodger, Schwabe, Spolar, Suckling, Trauger, Treesuwan, Wemmer, Wemmer, Wittayanarakul   +38 more
core   +2 more sources

T cell activation triggers reversible inosine-5′-monophosphate dehydrogenase assembly

Journal of Cell Science, 2018
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement.
Krisna C. Duong-Ly, Yin-Ming Kuo, M. Johnson, J. Cote, J. Kollman, J. Soboloff, G. Rall, A. Andrews, J. R. Peterson   +8 more
semanticscholar   +1 more source

Effects of Succinate-Based Antioxidant on in vitro Conversion of Methemoglobin in Oxyhemoglobin

Общая реаниматология, 2018
The purpose of the study — to determine the feasibility of using the succinate-based antioxidant for the in vitro reduction of excessive methemoglobin to oxyhemoglobin in blood.Materials and Methods. Blood sampling was performed in five healthy donors in
A. M. Chernysh, E. K. Kozlova, V. V. Moroz, V. A. Sergunova, O. E. Gudkova, E. A. Manchenko, A. P. Kozlov   +6 more
doaj   +1 more source

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The RNA world hypothesis assumes the abiotic synthesis of nucleotides, as well as their participation in nonenzymatic RNA replication.
S. Kim, D. O’Flaherty, Lijun Zhou, V. Lelyveld, J. Szostak   +4 more
semanticscholar   +1 more source