Results 141 to 150 of about 66,823 (327)
Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures
Aging Cell, EarlyView.Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu +17 more
wiley +1 more source
Effect of trolox, riboxin (inosine), and indralin on X-ray induced oxidative stress in A549 cells
Учёные записки Казанского университета: Серия Естественные наукиUsing dichlorofluorescein (DCF) fluorescence intensity, the oxidative stress in human lung adenocarcinoma A549 cells pretreated with trolox, riboxin (inosine), tartaric acid, and indralin was measured 2 h before, during, and 1 h after the X-ray radiation
L. A. Romodin
doaj +1 more source
Life, 2019 A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
doaj +1 more source
Infection of Soybean and Pea Nodules by \u3cem\u3eRhizobium\u3c/em\u3e spp. Purine Auxotrophs in the Presence of 5-aminoimidazole-4-Carboxamide Riboside [PDF]
, 1994 Purine auxotrophs of various Rhizobium species are symbiotically defective, usually unable to initiate or complete the infection process. Earlier studies demonstrated that, in the Rhizobium etli-bean symbiosis, infection by purine auxotrophs is partially
Diebold, Ronald J. +3 more
core +1 more source
Progress on the development of Class A GPCR‐biased ligands
British Journal of Pharmacology, EarlyView.Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales +20 more
wiley +1 more source
ACS Infectious Diseases, 2016 VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library.
Vinayak Singh +21 more
semanticscholar +1 more source
Lnc‐TPT1‐AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression
Cancer Science, EarlyView.Overexpression of TPT1‐AS1 could suppress the malignant phenotype and purine synthesis activation of breast cancer through competitive interaction with CBP, subsequently reducing the promoter H3K27ac signal and transcription of ATIC. Therefore, targeting the TPT1‐AS1/CBP/ATIC axis may provide a useful strategy for the treatment of patients with breast ...
Yiyun Zhang +10 more
wiley +1 more source
Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development
Journal of Cell Science, 2017 Adenosine to inosine (A-to-I) RNA editing is important for a functional brain, and most known sites that are subject to selective RNA editing have been found to result in diversified protein isoforms that are involved in neurotransmission. In the absence
Mikaela Behm +4 more
semanticscholar +1 more source
Frontiers in GeneticsThe in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the wobble position, are largely unexplored because very few unmodified A34 tRNA genes exist across the three domains of life.
Margaret A. Schmitt +2 more
doaj +1 more source
Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors
Frontiers in Immunology, 2017 IntroductionMany antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and tumor cell repopulation in multicellular organisms.
Yi Zhao +13 more
doaj +1 more source