Results 141 to 150 of about 86,294 (302)

Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus [PDF]

, 2018
Kristina Nystrôm, Paulina H. Wanrooij, J. Waldenström, Ludmila Adamek, Sofia Brunet, Joanna Said, Staffan Nilsson, Megan Wind‐Rotolo, Kristoffer Hellstrand, Heléne Norder, Ka‐Wei Tang, Martin Lagging   +11 more
openalex   +1 more source

iRNA-AI: identifying the adenosine to inosine editing sites in RNA sequences

OncoTarget, 2016
Catalyzed by adenosine deaminase (ADAR), the adenosine to inosine (A-to-I) editing in RNA is not only involved in various important biological processes, but also closely associated with a series of major diseases.
Wei Chen, Pengmian Feng, Hui Yang, Hui Ding, Hao Lin, K. Chou   +5 more
semanticscholar   +1 more source

Plant organelle C‐to‐U RNA editing factors can operate successfully in yeast (Saccharomyces cerevisiae) as an easily amenable eukaryotic system for their functional analysis

The FEBS Journal, EarlyView.
Plant‐type pentatricopeptide repeat proteins capable of C‐to‐U RNA editing perform faithfully when expressed in a new heterologous system, the yeast Saccharomyces cerevisiae. They were tested with constitutive and inducible expression and with a set of different solubility tags. PPR56, PPR65, and PPR78 from P.
Shyam Ramanathan, Annika Hanraths, Jingchan Xie, Mareike Schallenberg‐Rüdinger, Volker Knoop   +4 more
wiley   +1 more source

Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer

Microorganisms
Prostate cancer (PCa) is initially sensitive to androgen deprivation therapy (ADT) but ultimately develops resistance and progresses to castration-resistant prostate cancer (CRPC) with a poor prognosis.
Yao Yu, Leqian Li, Qishen Yang, Jingwen Xue, Benlin Wang, Ming Xie, Wentai Shangguan, Zhangrui Zhu, Peng Wu   +8 more
doaj   +1 more source

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance The RNA world hypothesis assumes the abiotic synthesis of nucleotides, as well as their participation in nonenzymatic RNA replication.
S. Kim, D. O’Flaherty, Lijun Zhou, V. Lelyveld, J. Szostak   +4 more
semanticscholar   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

T cell activation triggers reversible inosine-5′-monophosphate dehydrogenase assembly

Journal of Cell Science, 2018
T cell-mediated adaptive immunity requires naïve, unstimulated T cells to transition from a quiescent metabolic state into a highly proliferative state upon T cell receptor engagement.
Krisna C. Duong-Ly, Yin-Ming Kuo, M. Johnson, J. Cote, J. Kollman, J. Soboloff, G. Rall, A. Andrews, J. R. Peterson   +8 more
semanticscholar   +1 more source

Virocell Necromass Provides Limited Plant Nitrogen and Elicits Rhizosphere Metabolites That Affect Phage Dynamics

Plant, Cell &Environment, EarlyView.
ABSTRACT Bacteriophages impact soil bacteria through lysis, altering the availability of organic carbon and plant nutrients. However, the magnitude of nutrient uptake by plants from lysed bacteria remains unknown, partly because this process is challenging to investigate in the field.
Vlastimil Novak, Michelle C. M. van Winden, Thomas V. Harwood, Rachel Neurath, Suzanne M. Kosina, Katherine B. Louie, Matthew B. Sullivan, Simon Roux, Karsten Zengler, Vivek K. Mutalik, Trent R. Northen   +10 more
wiley   +1 more source

Stimulation of Parthenogenesis in Mouse Ovarian Follicles by Inhibitors of Inosine Monophosphate Dehydrogenase1 [PDF]

, 1990
Stephen M. Downs
openalex   +1 more source

Prebiotic Investigations and Reaction Network Analysis on the Wöhler‐RNA System

ChemSystemsChem, Volume 8, Issue 2, March 2026.
The prebiotic reaction toward the Wöhler‐RNA, a Proto‐RNA‐candidate, using aldehydes and biuret or triuret results in a mixture of the α‐ and β‐ furanosides and pyranosides. Investigation of the interconversion of these isomers shows different reactivity and stability of the biuret and triuret analogues as well as between the corresponding furanosides ...
Nathalie J. Kurrle, Maximilian Bechtel, Nathalie Hampel, Oliver Trapp   +3 more
wiley   +1 more source