Results 141 to 150 of about 71,261 (330)
Life, 2019 A mixture of sugar diphosphates is produced in reactions between small aldehyde phosphates catalysed by layered double hydroxide (LDH) clays under plausibly prebiotic conditions.
Harold S. Bernhardt
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Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis
Annals of Clinical and Translational Neurology, 2018 To test the safety, tolerability, and urate‐elevating capability of the urate precursor inosine taken orally or by feeding tube in people with amyotrophic lateral sclerosis (ALS).
K. Nicholson +16 more
semanticscholar +1 more source
Journal of Digestive Diseases, EarlyView.Mycophenolate mofetil (MMF) demonstrates superior efficacy and tolerability compared to azathioprine (AZA) in treatment‐naïve autoimmune hepatitis (AIH) patients. Meta‐analysis of five studies reveals higher complete biochemical response rates, increased Corticosteroid withdrawal rate, and fewer gastrointestinal side effects with MMF.
Muhammad Tayyab Anwar +12 more
wiley +1 more source
Effect of trolox, riboxin (inosine), and indralin on X-ray induced oxidative stress in A549 cells
Учёные записки Казанского университета: Серия Естественные наукиUsing dichlorofluorescein (DCF) fluorescence intensity, the oxidative stress in human lung adenocarcinoma A549 cells pretreated with trolox, riboxin (inosine), tartaric acid, and indralin was measured 2 h before, during, and 1 h after the X-ray radiation
L. A. Romodin
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Inosine – a Multifunctional Treatment for Complications of Neurologic Injury
Cellular Physiology and Biochemistry, 2018 Spinal cord injury (SCI) caused by trauma or disease leads to motor and sensory abnormalities that depend on the level, severity and duration of the lesion. The most obvious consequence of SCI is paralysis affecting lower and upper limbs.
Claire Doyle +3 more
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Aged Gut Microbiota Contributes to Cognitive Impairment and Hippocampal Synapse Loss in Mice
Aging Cell, EarlyView.Li et al. revealed that aged gut microbiota induces cognitive decline and microglia‐mediated synapse loss. Fecal Bifidobacterium pseudolongum abundance was reduced in patients with cognitive impairment and microbiota transplantation from patients with fewer B.p abundance yielded worse cognitive behavior in mice.
Mingxiao Li +12 more
wiley +1 more source
Inosine Released from Dying or Dead Cells Stimulates Cell Proliferation via Adenosine Receptors
Frontiers in Immunology, 2017 IntroductionMany antitumor therapies induce apoptotic cell death in order to cause tumor regression. Paradoxically, apoptotic cells are also known to promote wound healing, cell proliferation, and tumor cell repopulation in multicellular organisms.
Yi Zhao +13 more
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Chemical Labeling and Affinity Capture of Inosine-Containing RNAs Using Acrylamidofluorescein.
Bioconjugate chemistry, 2018 Adenosine-to-inosine (A-to-I) RNA editing is a widespread and conserved post-transcriptional modification, producing significant changes in cellular function and behavior.
Steve D. Knutson +2 more
semanticscholar +1 more source
IMPDH2's Central Role in Cellular Growth and Diseases: A Potential Therapeutic Target
Cell Proliferation, EarlyView.IMPDH2 is a rate‐limiting enzyme in guanine nucleotide biosynthesis. It plays diverse roles in various physiological and pathological processes: nucleotide metabolism, inflammation, immune function, ribosomal stress. Structural or regulatory alterations in IMPDH2 are linked to significant health issues, and critical relevance in disease progression. We
Zheng Li +8 more
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Frontiers in GeneticsThe in vivo codon decoding preferences of tRNAs with an authentic adenosine residue at position 34 of the anticodon, the wobble position, are largely unexplored because very few unmodified A34 tRNA genes exist across the three domains of life.
Margaret A. Schmitt +2 more
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