Results 171 to 180 of about 86,294 (302)
Advanced Science, Volume 13, Issue 1, 5 January 2026.Working model of Adss1‐mediated regulation of energy metabolism in adipose tissue. In beige adipocytes, Adss1 interacts with HDAC3 in the cytoplasm, and its loss reduces nuclear HDAC3 while increasing cytosolic fractions. This redistribution suppresses HDAC activity and enhances H3K27 acetylation at the Gk promoter, leading to transcriptional ...
Jingjing Sun +16 more
wiley +1 more source
Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis [PDF]
, 2018 Katharine Nicholson +16 more
openalex +1 more source
Advanced Science, Volume 13, Issue 2, 9 January 2026.The advent of aptamers has highlighted their potential as alternatives to antibodies, overcoming limitations of structural instability and production cost. However, conventional approaches such as SELEX remain slow and labor‐intensive. This review examines recent advances in aptamer engineering, emphasizing in vitro and AI‐driven in silico strategies ...
John V. L. Nguyen +5 more
wiley +1 more source
Metabolism‐Regulating Nanomedicines for Cancer Therapy
Advanced NanoBiomed Research, Volume 6, Issue 1, January 2026.This review highlights metabolism‐regulating nanomedicines designed to target glycolytic, lipid, amino acid, and nucleotide pathways in tumors. By incorporating metabolism‐regulating agents into versatile nanocarriers such as liposomes, micelles, dendrimers, and engineered bacteria, these platforms achieve targeted delivery, controlled release ...
Xiao Wu, Shiyi Geng, Jian Yang
wiley +1 more source
The Double Face of Base Excision Repair: Preventing and Triggering Double‐Strand Breaks
BioEssays, Volume 48, Issue 1, January 2026.Base excision repair is conserved from bacteria to man, robustly eliminating oxidized bases in DNA and reinserting the appropriate nucleotide to restore an intact double helix. Recent results describe conditions and mechanisms that misregulate long‐patch BER to generate double‐strand breaks, triggering chromosome fragmentation and cell death, altering ...
Susan M. Gasser
wiley +1 more source
Cancer Medicine, Volume 15, Issue 1, January 2026.ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo +2 more
wiley +1 more source
The Protective Effects of Inosine Against Chemical Hypoxia on Cultured Rat Oligodendrocytes
, 2011 Quanrui Ma +9 more
openalex +2 more sources
Food Frontiers, Volume 7, Issue 1, January 2026.Fried potato consumption is increasingly associated with metabolic disorders, yet preventive strategies remain poorly understood. In a 13‐week mouse model, long‐term potato chip intake induced significant glycolipid metabolic disturbances and tissue damage, which were ameliorated by fish oil supplementation through modulation of inflammation, hepatic ...
Xuzhi Wan +10 more
wiley +1 more source