Results 171 to 180 of about 69,045 (225)
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Molecular and General Genetics MGG, 1988
Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
H, Inouye +3 more
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Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
H, Inouye +3 more
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Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids
Journal of Medicinal Chemistry, 1984A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase from Escherichia coli. All of the IMP analogues that possessed electron-withdrawing substituents on the phenyl ring of a benzylthio group placed at the 2-position of IMP showed strong inhibition ...
C G, Wong, R B, Meyer
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Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis
The FASEB Journal, 2021Abstract Inosine monophosphate (IMP) is the intracellular precursor for both adenosine monophosphate and guanosine monophosphate and thus plays a central role in intracellular purine metabolism. IMP can also serve as an extracellular signaling molecule, and can regulate diverse processes such as taste sensation ...
Marianna, Lovászi +5 more
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Molecular Conformation of Inosine
Nature, 1969INOSINE is one of the rare nucleosides found in nucleic acids. It occurs especially in transfer ribonucleic acid where it appears to form part of a number of anticodons1,2. It can form a base pair with any one of the bases adenine, uracil or cytidine in the third codon1,2 position, and the possibility of atypical base pairs is part of the “wobble ...
P, Tollin, A R, Munns
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Synthesis of Inosine Polyphosphates from Inosine 5’-Phosphate
Advanced Materials Research, 2014Treatment of inosine 5’-phosphate (IMP) with 2,2’-dithiodianiline/triphenylphosphine provided an efficient method for the synthesis of inosine 5′-phosphoropiperidate under mild conditions. Inosine 5’-triphosphate (ITP) and inosine 5′-diphosphate (IDP) were efficiently synthesized from inosine 5’-phosphoropiperidate via the activation P(V)—N bond by 4,5-
Jian Sun, Shan Shan Gong, Qi Sun
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Renal preservation with inosine
Urology, 1980Isosine improved post-transplantation function of canine kidneys subjected to thirty minutes of normothermic ischemia followed by flushing and twenty-four-hour cold storage. Inosine was not able to improve renal preservation when cold storage was extended to forty-eight hours after thirty minutes of normothermic ischemia.
A J, Maggio +3 more
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Detection of Inosine in Messenger RNA by Inosine-Specific Cleavage
Biochemistry, 1997Double-stranded RNA adenosine deaminases catalyze the conversion of adenosine to inosine within double-stranded RNA. A few candidate biological substrates for these enzymes have been discovered by noticing discrepancies between genomic and cDNA sequences.
D P, Morse, B L, Bass
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Inosine-coated bacteriophage T4
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract A method for the preparation of inosine-bacteriophage T 4 conjugate is described, based on opening the C-2′–C-3′ bond in the ribose moiety of inosine with NaIO 4 , reacting the product with bacteriophage T 4 , and stabilizing the bond formed by reduction with NaBH 3 .
B, Bonavida +3 more
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Factors affecting inosinate synthesis and inosine triphosphate accumulation in human erythrocytes
Canadian Journal of Biochemistry, 1977Measurements of rates of inosinate synthesis from radioactive hypoxanthine by human erythrocytes show a large degree of individual variation. Rates of inosinate synthesis also vary with the pH and phosphate concentration of the incubation medium. This may be due to changes in the rate of phosphoribosyl pyrophosphate synthesis, and the stimulatory ...
J F, Henderson +5 more
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