Results 191 to 200 of about 54,859 (243)
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Inosine Monophosphate and Inosine Differentially Regulate Endotoxemia and Bacterial Sepsis.
FASEB Journal, 2021Abstract Inosine monophosphate (IMP) is the intracellular precursor for both adenosine monophosphate and guanosine monophosphate and thus plays a central role in intracellular purine metabolism. IMP can also serve as an extracellular signaling molecule, and can regulate diverse processes such as taste sensation ...
Pal Pacher +2 more
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Detection of Inosine in Messenger RNA by Inosine-Specific Cleavage
Biochemistry, 1997Double-stranded RNA adenosine deaminases catalyze the conversion of adenosine to inosine within double-stranded RNA. A few candidate biological substrates for these enzymes have been discovered by noticing discrepancies between genomic and cDNA sequences.
D P, Morse, B L, Bass
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Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971
Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
H, Inouye +3 more
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Abstract Antibodies against a single minor base, inosine, have been prepared by immunizing rabbits with a conjugate of inosine and bovine serum albumin. The antisera obtained were fairly specific for inosine, only guanosine among the major nucleosides being capable of cross-reacting with them.
H, Inouye +3 more
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Molecular Conformation of Inosine
Nature, 1969INOSINE is one of the rare nucleosides found in nucleic acids. It occurs especially in transfer ribonucleic acid where it appears to form part of a number of anticodons1,2. It can form a base pair with any one of the bases adenine, uracil or cytidine in the third codon1,2 position, and the possibility of atypical base pairs is part of the “wobble ...
P, Tollin, A R, Munns
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On the tautomeric structure of inosine
Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971Abstract The suggestion that 6-keto and 6-enol tautomers of inosine may be of similar stability in neutral aqueous solution has been investigated by means of Raman spectroscopy. Spectra of aqueous solutions of inosine and its methylated analogs were obtained in the region 2000-200 cm−1 using argon laser excitation, and indicate that inosine exists ...
G C, Medeiros, G J, Thomas
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Molecular and General Genetics MGG, 1988
Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Two complementary 24 base single stranded oligonucleotides containing randomly located inosine residues were synthesized in vitro. Once annealed, the two oligonucleotides were cloned into derivatives of ColE1 and transformed into Escherichia coli. Sequence analysis of 157 clones yielded 305 mutations. The pattern of the mutations revealed the following:
P L, Nordmann +2 more
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Renal preservation with inosine
Urology, 1980Isosine improved post-transplantation function of canine kidneys subjected to thirty minutes of normothermic ischemia followed by flushing and twenty-four-hour cold storage. Inosine was not able to improve renal preservation when cold storage was extended to forty-eight hours after thirty minutes of normothermic ischemia.
A J, Maggio +3 more
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Vasoactivity of inosine in the rat
Pharmacological Research Communications, 1980Summary Inosine increases the blood pressure in the rat independently of the autonomic nervous system. The mechanism of this hypertensive effect was investigated in 18 rats anesthetized with sodium pentobarbital. Inosine (0.01 M) infused at 0.03, 0.06, and 0.08 ml/min into the external jugular vein consistently caused a sustained, dose-dependent rise
R L, Prewitt, J M, Sullivan
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Inhibitors of inosinic acid dehydrogenase. 2-Substituted inosinic acids
Journal of Medicinal Chemistry, 1984A series of 2-substituted inosine monophosphate (IMP) and inosine derivatives were synthesized and tested for inhibitory activity against IMP dehydrogenase from Escherichia coli. All of the IMP analogues that possessed electron-withdrawing substituents on the phenyl ring of a benzylthio group placed at the 2-position of IMP showed strong inhibition ...
C G, Wong, R B, Meyer
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Synthesis of Inosine Polyphosphates from Inosine 5’-Phosphate
Advanced Materials Research, 2014Treatment of inosine 5’-phosphate (IMP) with 2,2’-dithiodianiline/triphenylphosphine provided an efficient method for the synthesis of inosine 5′-phosphoropiperidate under mild conditions. Inosine 5’-triphosphate (ITP) and inosine 5′-diphosphate (IDP) were efficiently synthesized from inosine 5’-phosphoropiperidate via the activation P(V)—N bond by 4,5-
Jian Sun, Shan Shan Gong, Qi Sun
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