Results 111 to 120 of about 270,142 (371)
Activation of phospholipase C beta 2 by the alpha and beta gamma subunits of trimeric GTP-binding protein [PDF]
, 1993 Cotransfection assays were used to show that the members of the GTP-binding protein Gq class of alpha subunits could activate phospholipase C (PLC) beta 2.
Katz, Arieh +2 more
core
Aggregate, EarlyView.The selenium‐containing polyurethane (SePU) thermo‐sensitive hydrogel (SePU/HBC) was constructed by incorporating SePU into hydroxybutyl chitosan (HBC). This hydrogel alleviates endoplasmic reticulum stress (ERS) and inhibits cell apoptosis by activating the unfolded protein response (UPR), thereby promoting diabetic wound healing.
Mo Zhai +8 more
wiley +1 more source
Hysteresis and bi-stability by an interplay of calcium oscillations and action potential firing [PDF]
, 2006 Many cell types exhibit oscillatory activity, such as repetitive action potential firing due to the Hodgkin-Huxley dynamics of ion channels in the cell membrane or reveal intracellular inositol triphosphate (IP$_3$) mediated calcium oscillations (CaOs) by calcium-induced calcium release channels (IP$_3$-receptor) in the membrane of the endoplasmic ...
arxiv +1 more source
Natural History and Diagnostic Findings in an Adult Man Diagnosed With Attenuated Krabbe Disease
American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.ABSTRACT Krabbe disease (KD), or globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in galactocerebrosidase (GALC), leading to psychosine (galactosylsphingosine) accumulation and myelin damage.
Eamon P. McCarron +8 more
wiley +1 more source
Data-driven modelling of the inositol trisphosphate receptor (IPR) and its role in calcium induced calcium release (CICR) [PDF]
arXiv, 2015 We give a review of the current state of the art of data-driven modelling of the inositol trisphosphate receptor (IPR). After explaining that the IPR plays a crucial role as a central regulator in calcium dynamics, several sources of relevant experimental data are introduced.
arxiv
IRBIT a Master Regulator of Cell Physiology [PDF]
, 2017 (excerpt) Hormones and neurotransmitters regulate cell functions by binding to their receptors, which activate intracellular signaling and produce the physiological response [1].
Bouyer, Patrice G +2 more
core +1 more source
An update on nuclear calcium signalling [PDF]
, 2009 Over the past 15 years or so, numerous studies have sought to characterise how nuclear calcium (Ca2+) signals are generated and reversed, and to understand how events that occur in the nucleoplasm influence cellular Ca2+ activity, and vice versa. In this
Bootman, Martin D. +4 more
core +1 more source
Animal Models and Experimental Medicine, EarlyView.In a study combining network pharmacological analysis and experimental verification, yunweiling has been shown improve functional constipation by inhibiting the PI3K‐Akt‐p53 signaling pathway and reducing the expression of TP53. Abstract Background This study investigated the impacts and mechanisms of yunweiling in the management of Functional ...
Peng Zhang +6 more
wiley +1 more source
Poultry Science, 2020 : Cobb 400, male broilers (n=4,752) were fed one of 12 diets, with 12 pens/diet and 33 birds/pen. Treatments consisted of 3 levels of phytate P (0.24, 0.345, or 0.45%) and 4 doses of phytase (0, 500, 1,000, or 2,000 phytase units (FTU)/kg).
C.L. Walk, S.V. Rama Rao
doaj
Modeling stochastic Ca$^{2+}$ release from a cluster of IP$_3$-sensitive receptors [PDF]
arXiv, 2004 We focused our attention on Ca$^{2+}$ release from the endoplasmic reticulum through a cluster of inositol 1,4,5-trisphosphate (IP$_3$) receptor channels. The random opening and closing of these receptors introduce stochastic effects that have been observed experimentally.
arxiv