Results 121 to 130 of about 270,142 (371)

Oncogenic K-Ras suppresses IP₃-dependent Ca²⁺ release through remodeling of IP₃Rs isoform composition and ER luminal Ca²⁺ levels in colorectal cancer cell lines [PDF]

, 2014
The GTPase Ras is a molecular switch engaged downstream of G-protein coupled receptors and receptor tyrosine inases that controls multiple cell fate-determining signalling athways.
Bootman, Martin D., Cook, Simon J., Foets, Thomas C. F., Pierro, Cristina, Roderick, H. Llewelyn   +4 more
core   +2 more sources

Neuroimaging Biomarkers for Friedreich Ataxia: A Cross‐Sectional Analysis of the TRACK‐FA Study

Annals of Neurology, EarlyView.
Objective We aimed to quantify differences in the brain and spinal cord between Friedreich ataxia and controls, stratified by age and disease stage, including for the first time in young children. Methods TRACK‐FA is the largest prospective, longitudinal, multi‐modal neuroimaging study in Friedreich ataxia to date.
Nellie Georgiou‐Karistianis, Louise A. Corben, Eric F. Lock, Helena Bujalka, Isaac Adanyeguh, Manuela Corti, Dinesh K. Deelchand, Martin B. Delatycki, Imis Dogan, Jennifer Farmer, Marcondes C. França Jr., Anthony S. Gabay, William Gaetz, Ian H. Harding, James Joers, Michelle A. Lax, Jiakun Li, David R. Lynch, Thomas H. Mareci, Alberto R. M. Martinez, Massimo Pandolfo, Marina Papoutsi, Richard G. Parker, Kathrin Reetz, Thiago J.R. Rezende, Timothy P. Roberts, Sandro Romanzetti, David A. Rudko, Susmita Saha, Jörg B. Schulz, Sub H. Subramony, Veena G. Supramaniam, Christophe Lenglet, Pierre‐Gilles Henry   +33 more
wiley   +1 more source

When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments

Endocrine and Metabolic Science
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been a matter of contention.
V. Unfer, E. Kandaraki, L. Pkhaladze, S. Roseff, M.H. Vazquez-Levin, A.S. Laganà, C. Shiao-Yng, M.I.M. Yap-Garcia, N.D.E. Greene, C.O. Soulage, A. Bevilacqua, S. Benvenga, D. Barbaro, B. Pintaudi, A. Wdowiak, C. Aragona, Z. Kamenov, M. Appetecchia, G. Porcaro, I. Hernandez Marin, F. Facchinetti, T. Chiu, O. Pustotina, O. Papalou, M. Nordio, T. Cantelmi, P. Cavalli, I. Vucenik, R. D'Anna, V.R. Unfer, S. Dinicola, S. Salehpour, A. Stringaro, M. Montaninno Oliva, M. Tugushev, N. Prapas, M. Bizzarri, M.S.B. Espinola, C. Di Lorenzo, A.C. Ozay, J. Nestler   +40 more
doaj  

An Evaluation of a Nutraceutical with Berberine, Curcumin, Inositol, Banaba and Chromium Picolinate in Patients with Fasting Dysglycemia

Diabetes, Metabolic Syndrome and Obesity, 2020
Giuseppe Derosa, 1–3 Angela D’Angelo, 1, 2 Arianna Vanelli, 4 Pamela Maffioli 1, 3 1Center of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo,
Derosa G, D'Angelo A, Vanelli A, Maffioli P   +3 more
doaj  

Myo-inositol effects in women with PCOS: a meta-analysis of randomized controlled trials

Endocrine Connections, 2017
Myo-inositol (MI) supplementation in women with polycystic ovary syndrome (PCOS) has been evaluated over the last years. Many hormonal and reproductive impairments associated with this disorder seem relieved by the supplement.
Vittorio Unfer1,, Fabio Facchinetti2,, Beatrice Orrù3,, Barbara Giordani, John Nestler   +4 more
doaj   +1 more source

Intercellular synchronization of diffusively coupled astrocytes [PDF]

arXiv, 2010
We examine the synchrony of the dynamics of localized [Ca^{2+}]_i oscillations in internal pool of astrocytes via diffusing coupling of a network of such cells in a certain topology where cytosolic Ca^{2+} and inositol 1,4,5-triphosphate (IP3) are coupling molecules; and possible long range interaction among the cells.
arxiv  

Autosomal Recessive Cerebellar Ataxias: Translating Genes to Therapies

Annals of Neurology, EarlyView.
Autosomal recessive cerebellar ataxias are disabling neurodegenerative genetic conditions affecting balance and coordination. Advancements in genomic testing have improved diagnosis, leading to a new focus on the development of targeted precision therapeutics addressing cellular, biochemical, and genetic disease mechanisms with a resulting emphasis on ...
Brent L. Fogel, Thomas Klopstock, David R. Lynch, Francesca Maltecca, Mayank Verma, Berge A. Minassian, Frances M. Platt, Débora Farina Gonçalves, Hélène Puccio, Andreas Roos, Matthis Synofzik   +10 more
wiley   +1 more source

The effect of point mutations on energy conduction pathways in proteins [PDF]

arXiv, 2011
Energetically responsive residues of the 173 amino acid N-terminal domain of the cardiac Ryanodine receptor RyR2 are identified by a simple elastic net model. Residues that respond in a correlated way to fluctuations of spatially neighboring residues specify a hydrogen bonded path through the protein.
arxiv  

IRE1 alpha may be causing abnormal loss of p53 at post transcriptional level in chronic myeloid leukemia [PDF]

arXiv, 2017
Current treatment strategy for chronic myeloid leukemia (CML) mainly includes inhibition of tyrosine kinase activity, which has dramatically improved the prognosis of the disease but without cure. In addition some patients may become drug resistant. Thus there is still the need for other therapies to avoid resistance and if possible to cure the disease.
arxiv  

Inositol transport proteins [PDF]

FEBS Letters, 2015
The cyclic polyol myo‐inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain. This review sums up inositol transporters from eukaryotic organisms, elucidating their vital role in regulating the intracellular distribution and uptake of inositol.
openaire   +3 more sources