Results 111 to 120 of about 162,796 (303)
Advanced Science, EarlyView.Resolution pharmacology is an emerging strategy to tackle inflammatory pathologies. Bioinspired meroterpenoids induce a lipid mediator class switch toward inflammation resolution in vitro and in vivo by targeting key nodes in lipid mediator biosynthesis and neutral lipid dynamics.
Lorenz Waltl +20 more
wiley +1 more source
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3 [PDF]
, 2008 Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in ataxin-3 (SCA3, MJD1) protein.
X. Chen +15 more
core +1 more source
Efficiency of the D-chiro-inositol for the polycystic ovary syndrome
Репродуктивная эндокринология, 2019 Polycystic ovary syndrome (PCOS) is a common endocrine disorder that develops in 10–15% of reproductive aged women. Over the past two decades, the inositol effectiveness in normalizing the clinical and hormonal disorders associated with PCOS has been ...
Т. Л. Архипкина +1 more
doaj +1 more source
Advanced Science, EarlyView.B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu +4 more
wiley +1 more source
Inositol transport proteins [PDF]
, 2015 The cyclic polyol myo-inositol is a key molecule in many different metabolic pathways among all organisms; in addition, it is fundamental for osmotic balance in the mammalian brain.
Schneider, Sabine
core +1 more source
Ciência e Agrotecnologia, 2006 Dois experimentos foram conduzidos utilizando um delineamento inteiramente casualizado, com seis tratamentos e três repetições, para avaliar o efeito de misturas vitamínicas (MV) na larvicultura do jundiá (Rhamdia quelen).
Carlos Guilherme Trombetta +2 more
doaj +1 more source
A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Advanced Science, EarlyView.Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
The Role of Inositol and the Principles of Labelling, Extraction, and Analysis of Inositides in Mammalian Cells [PDF]
, 2010 Inositides have an important impact on diverse areas of cellular regulation. However, since this area has grown exponentially from the mid 1980s onwards, many workers find themselves relatively new to the held.
Barker, Christopher J. +5 more
core +1 more source
Repurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.
Hongxiang Zeng +16 more
wiley +1 more source
Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis
Ecotoxicology and Environmental SafetyLithium, which is widely used in medicine and batteries, has become increasingly prevalent in the environment, raising concerns about its impact on human health.
Zhen Guan +6 more
doaj +1 more source