Results 111 to 120 of about 268,739 (302)

Lithium carbonate exposure disrupts neurodevelopment by perturbing primary cilia and ER homeostasis

Ecotoxicology and Environmental Safety
Lithium, which is widely used in medicine and batteries, has become increasingly prevalent in the environment, raising concerns about its impact on human health.
Zhen Guan, Yingchao Liang, Zhiqiang Zhu, Aiyun Yang, Shen Li, Xiuwei Wang, Jianhua Wang   +6 more
doaj   +1 more source

The Tonoplastic Inositol Transporter INT1 From Arabidopsis thaliana Impacts Cell Elongation in a Sucrose-Dependent Way

Frontiers in Plant Science, 2018
The tonoplastic inositol transporter INT1 is the only known transport protein in Arabidopsis that facilitates myo-inositol import from the vacuole into the cytoplasm.
Sabrina Maria Strobl, Dominik Kischka, Ingo Heilmann, Grégory Mouille, Sabine Schneider   +4 more
doaj   +1 more source

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer [PDF]

, 2019
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.
Alzayady, Kamil J., Ando, Hideaki, Bartok, Adam, Bánsághi, Száva, Csordás, György, Golenár, Tünde, Hajnóczky, György, Joseph, Suresh K., Katona, Máté, Mikoshiba, Katsuhiko, Nichtova, Zuzana, Thomas, V. Kaye, Weaver, David, Yule, David I.   +13 more
core   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Mechanistic insights into inositol-mediated rumen function promotion and metabolic alteration using in vitro and in vivo models

Frontiers in Veterinary Science
Inositol is a bioactive factor that is widely found in nature; however, there are few studies on its use in ruminant nutrition. This study investigated the effects of different inositol doses and fermentation times on rumen fermentation and microbial ...
Guopei Yin, Zhe Sun, Zhe Sun, Zhe Sun, Zhanqing Wang, Yuanhong Xia, Long Cheng, Guixin Qin, Natnael D. Aschalew, Natnael D. Aschalew, Hongyun Liu, Xuefeng Zhang, Qilu Wu, Weigang Zhang, Wei Zhao, Tao Wang, Tao Wang, Yuguo Zhen, Yuguo Zhen   +18 more
doaj   +1 more source

Buckwheat - an old crop with new health prospects [PDF]

, 2007
Interest in buckwheat has incresed due to it being a valuable raw material for functional food production. It has been reported to have general beneficial effects on health. Buckwheat competes well with weeds and suffers little from other pests.
Keskitalo, Marjo, Ketoja, Elise, Kontturi, Markku, Mäki, Maarit, Pihlava, Juha-Matti, Rantamäki, Pirjo, Tupasela, Tuomo   +6 more
core  

A consensus roadmap for post‐traumatic epilepsy: Clinical biomarkers, research priorities, policy barriers, and pathways to interventional trials

Epilepsia, EarlyView.
Abstract Understanding the mechanisms underlying post‐traumatic epilepsy (PTE) following traumatic brain injury (TBI), and developing strategies to prevent or modify its progression, has been the focus of large collaborative efforts within the epilepsy and TBI research communities for over a decade.
Elisa R. Zanier, Ilaria Lisi, Elaine K. O'Loughlin, Federico Moro, Edilberto Amorim, David L. Brody, Daniel J. Correa, Dominique Duncan, Pavel Klein, Firas H. Kobeissy, Wolfgang Löscher, Edward J. Needham, Asla Pitkänen, Mary Jo Pugh, Jack Somers, Annamaria Vezzani, Amy K. Wagner, Laura S. Lubbers, International Conference on PTE Attendees, Denes Agoston, Edilberto Amorim, Sneha Anand, Hibah Awwad, Ginevra Bayon, Naima Belhachemi, Akash Bera, Costanza Bertani, Guido Bertolini, David L. Brody, Serena Brusatori, Francesca Buffelli, Aurora Chiapperini, Mara Chioccola, Severn Churn, Daniel J. Correa, Ramon Diaz‐Arrastia, Chris Dulla, Dominique Duncan, Chiara Ferlito, Aristea Galanopoulou, Angela Galic, Heidi Matos Galicia, Bin Gu, William Haskins, Victoria Johnson, Nigel Jones, Lowie Joseph, Pavel Klein, Firas Kobaissy, Ilaria Lisi, David Loane, Luther Loose, Laura S. Lubbers, Wolfgang Löscher, Edoardo Mazzone, Melissa Miller, Federico Moro, Edward J. Needham, Irma Wati Ngadimon, Terence O’Brien, Elaine K. O’Loughlin, Asla Pitkanen, Mary Jo Pugh, Teresa Giovanna Ravizza, Giuseppe Remuzzi, Massimo Rizzi, Rossella Di Sapia, Tawfeeq Shekh‐Ahmad, Doug Smith, Jack Somers, Kevin Staley, Francesca Tribuzio, Alexandra Ulyanova, Gloria Vegliante, Annamaria Vezzani, Joost Wagenaar, Amy K. Wagner, Kevin W. Wang, Justin Weppner, Peter J. West, Karen Wilcox, John Wolf, Elisa R. Zanier   +82 more
wiley   +1 more source

Influence of Inositol on The Content of Oxidatively Modified Proteins and Morphological Changes in the Skin of Animals of Different Sexes with Metabolic Associated Fatty Liver Disease

Archive of Clinical Medicine
Introduction. Metabolic dysfunction-associated steatotic liver disease (MASLD) remains a leading cause of chronic liver disease worldwide. Data on the global epidemic of obesity are driving a number of obesity-related complications, including MASLD, and ...
Olesya Sopel, Olha Denefil
doaj   +1 more source

CD28 and T cell antigen receptor signal transduction coordinately regulate interleukin 2 gene expression in response to superantigen stimulation. [PDF]

, 1992
Activation of an immune response requires intercellular contact between T lymphocytes and antigen-presenting cells (APC). Interaction of the T cell antigen receptor (TCR) with antigen in the context of major histocompatibility molecules mediates signal ...
Fraser, JD, Newton, ME, Weiss, A
core  

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross‐Species Adverse Outcome Pathway Network for Reproductive Toxicity

Environmental Toxicology and Chemistry, EarlyView.
Cross‐species extrapolation of adverse outcome pathway network on reproductive toxicity under the One Health perspective using new approach methodologies. AOP = adverse outcome pathway. Abstract Although ecotoxicological and toxicological risk assessments are performed separately from each other, recent efforts have been made in both disciplines to ...
Elizabeth Dufourcq Sekatcheff, Jaeseong Jeong, Jinhee Choi   +2 more
wiley   +1 more source