Inositol 1,3,4,5,6-pentakisphosphate 2-kinase is a distant IPK member with a singular inositide binding site for axial 2-OH recognition [PDF]
, 2010 Inositol phosphates (InsPs) are signaling molecules with multiple roles in cells. In particular Graphic (InsP6) is involved in mRNA export and editing or chromatin remodeling among other events.
Agarwal +35 more
core +2 more sources
An allosteric model of the inositol trisphosphate receptor with nonequilibrium binding [PDF]
Physical Biology, 11(5):056001, 2014, 2013 The inositol trisphosphate receptor (IPR) is a crucial ion channel that regulates the Ca$^{2+}$ influx from the endoplasmic reticulum (ER) to the cytoplasm. A thorough study of the IPR channel contributes to a better understanding of calcium oscillations and waves.
arxiv +1 more source
A defective ABC transporter of the MRP family, responsible for the bean lpa1 mutation, affects the regulation of the phytic acid pathway, reduces seed myo-inositol and alters ABA sensitivity [PDF]
, 2011 We previously identified the lpa1 (low phytic acid) 280-10 line that carries a mutation conferring a 90% reduction in phytic acid (InsP6) content. In contrast to other lpa mutants, lpa1(280-10) does not display negative pleiotropic effects.
Bollini, Roberto +10 more
core +1 more source
Inositol for depressive disorders [PDF]
Cochrane Database of Systematic Reviews, 2002 There are a number of effective interventions for the treatment of depression. It is possible that the efficacy of these treatments will be improved further by the use of adjunctive therapies such as inositol.1. To determine the effectiveness of inositol in the treatment of depression.2.
Taylor, M +3 more
openaire +3 more sources
A tale of two inositol trisphosphates. [PDF]
, 2016 Between spring 1982 and autumn 1984 the physiological role of Ins(1,4,5)P3 as a calcium-mobilizing second messenger was first suggested and then experimentally established.
core +2 more sources
In silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness [PDF]
PLOS ONE, Vol 8, Issue 9, Page e73937, September 2013, 2013 The inositol-phosphate messenger inositol(1,3,4,5)tetrakisphosphate (IP4) is essential for thymocyte positive selection by regulating plasma-membrane association of the protein tyrosine kinase Itk downstream of the T cell receptor (TCR). IP4 can act as a soluble analog of the phosphoinositide 3-kinase (PI3K) membrane lipid product phosphatidylinositol ...
arxiv +1 more source
EIN2 and COI1 control the antagonism between ethylene and jasmonate in adventitious rooting of Arabidopsis thaliana thin cell layers [PDF]
, 2019 Auxins induce adventitious roots (ARs) in numerous culture-systems, and indole-3-butyric acid (IBA) is frequently the best AR-inducer. Vitamin requirements vary according to species, explant, and culture-conditions. Arabidopsis thaliana thin cell layers (
Betti, Camilla +3 more
core +1 more source
Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
Ammann +30 more
core +1 more source
Involvement of Inositol in Reproduction [PDF]
Nutrition Reviews, 2002 Inositol is involved in several aspects of reproduction. It affects overall embryogenesis, may prevent neural tube defects, and stimulates the production of lung surfactant. This article will review the involvement of inositol in reproduction. After describing the biologic function of inositol and its derivatives, studies are quoted in which the role ...
Beemster, P. +2 more
openaire +4 more sources
Inositol and herbal substances as elements of complementary therapy in patients with PCOS
Journal of Education, Health and Sport, 2023 Introduction: Polycystic ovary syndrome is a common hormonal disorder in women and the leading cause of female infertility. Traditional therapeutic methods often do not yield the expected results, hence the need to explore new treatment strategies ...
Arkadiusz Aab +5 more
doaj +1 more source