Results 41 to 50 of about 268,739 (302)

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]

, 2001
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J., Bootman, Martin D., De Smedt, Humbert, de Smet, Patrick, Holmes, Andrew, Lipp, Peter, Missiaen, Ludwig, Parys, Jan B., Thomas, David, Thuring, Jan, Tovey, Stephen C., Young, Kenneth W.   +11 more
core  

Cellular IP₆ Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP₆ Are Attenuated for Infection and Replication [PDF]

, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Böcking, Till, Faysal, K. M.Rifat, Fletcher, Adam J., Freed, Eric O., James, Leo C., Kleinpeter, Alex, Mallery, Donna L., Novikova, Mariia, Saiardi, Adolfo, Vaysburd, Marina, Wilson, Miranda S.C.   +10 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Efficient Multi-Enzymes Immobilized on Porous Microspheres for Producing Inositol From Starch

Frontiers in Bioengineering and Biotechnology, 2020
In vitro synthetic enzymatic biosystem is considered to be the next generation of biomanufacturing platform. This biosystem contains multiple enzymes for the implementation of complicated biotransformatiom.
Pingping Han, Xigui Zhou, Chun You, Chun You   +3 more
doaj   +1 more source

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being restricted to the confines of the ER. The reason for this compartmentalization is unclear.
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Phytic acid degradation by phytase – as viewed by 31P NMR and multivariate curve resolution [PDF]

, 2007
The 31P NMR method is a most direct and useful method to describe the degradation of phytic acid to lower inositol phosphates by the action of the enzyme phytase.
Engelsen, Søren Balling, Nielsen, Merete Møller, Viereck, Nanna   +2 more
core  

Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]

, 2016
Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K, Ayala, R, Calderari, S, Cazier, JB, Collins, S, Domange, C, Dumas, ME, Gauguier, D, Gu, Q, Holmes, E, Hue, C, Lindon, JC, Mitchell, S, Navratil, V, Nicholson, JK, Otto, GW, Rodriguez Martinez, A, Suárez-Zamorano, N, Wallis, R, Wang, Y, Wilder, S   +20 more
core   +6 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

STUDY OF SOME FACTORS AFFECT ON CLONAL PROPAGATION FOR "GARDENIA" PLANT Gardenia jasminoides VAR. VEITCHII BY TISSUE CULTURE [PDF]

Mesopotamia Journal of Agriculture, 2013
This experiments were conducted to study the effect of some important factors on growth and multiplication of ornamental plant dendritic "Gardenia" Gardenia Jasminoides var. Veitchii culturing on MS medium In vitro.
Ammar Zeki Kassab Bashi
doaj   +1 more source