Results 41 to 50 of about 162,796 (303)

Enantiodivergence in Small-Molecule Catalysis of Asymmetric Phosphorylation:  Concise Total Syntheses of the Enantiomeric d-myo-Inositol-1-phosphate and d-myo-Inositol-3-phosphate [PDF]

, 2016
Peptide-based catalysts have been found that catalyze the enantiodivergent phosphorylation of a meso myo-inositol-derived triol (1). The sequential screening of random peptide libraries, followed by the evaluation of a focused library, led to the ...
Bianca R. Sculimbrene (2204239), Adam J. Morgan (2450671), Scott J. Miller (1308798)   +2 more
core   +1 more source

myo-inositol uptake is essential for bulk inositol phospholipid but not glycosylphosphatidylinositol synthesis in Trypanosoma brucei [PDF]

, 2012
myo-Inositol is an essential precursor for the production of inositol phosphates and inositol phospholipids in all eukaryotes. Intracellular myo-inositol is generated by de novo synthesis from glucose 6-phosphate or is provided from the environment via ...
Gonzalez-Salgado, A., Bütikofer, P., Monika Rauch, Pascal Mäser, Rauch, Monika, Sigel, Erwin, Erwin Sigel, Greganova, Eva, Steinmann, M. E., Mäser, Pascal, Bütikofer, Peter, Rauch, M., Sigel, E., Michael E. Steinmann, Mäser, P., Amaia Gonzalez-Salgado, Gonzalez-Salgado, Amaia, Steinmann, Michael E, Eva Greganova, Peter Bütikofer, Greganova, E.   +20 more
core   +1 more source

Preparation of azide biosynthetic surrogates of myo-Inositol [PDF]

, 2015
As a prelude to biomolecular incorporation studies, practical routes to a series of four regioisomeric azido-deoxy derivatives of inositol that mimic the natural myo-stereochemistry are described.
Markus R. Wenk (136744), Martin Lear (17161933), Shareef M. Ismail (17192380), Sandip Pasari (17192377)   +3 more
core   +2 more sources

When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments

Endocrine and Metabolic Science
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder that affects a large proportion of women. Due to its heterogeneity, the best diagnostic strategy has been a matter of contention.
V. Unfer, E. Kandaraki, L. Pkhaladze, S. Roseff, M.H. Vazquez-Levin, A.S. Laganà, C. Shiao-Yng, M.I.M. Yap-Garcia, N.D.E. Greene, C.O. Soulage, A. Bevilacqua, S. Benvenga, D. Barbaro, B. Pintaudi, A. Wdowiak, C. Aragona, Z. Kamenov, M. Appetecchia, G. Porcaro, I. Hernandez Marin, F. Facchinetti, T. Chiu, O. Pustotina, O. Papalou, M. Nordio, T. Cantelmi, P. Cavalli, I. Vucenik, R. D'Anna, V.R. Unfer, S. Dinicola, S. Salehpour, A. Stringaro, M. Montaninno Oliva, M. Tugushev, N. Prapas, M. Bizzarri, M.S.B. Espinola, C. Di Lorenzo, A.C. Ozay, J. Nestler   +40 more
doaj   +1 more source

Distribution and fatty acid composition of phosphoglycerides in normal human brain

Journal of Lipid Research, 1968
A thin-layer chromatographic procedure for the isolation of tissue phospholipids and their subsequent analysis is described. The method has been applied to the determination of the fatty acids of phosphoglycerides in human brain from the early fetal ...
Lars Svennerholm
doaj   +1 more source

Discovery of a Catalytic Asymmetric Phosphorylation through Selection of a Minimal Kinase Mimic:  A Concise Total Synthesis of d-myo-Inositol-1-Phosphate [PDF]

, 2016
Discovery of a Catalytic Asymmetric Phosphorylation through Selection of a Minimal Kinase Mimic:  A Concise Total Synthesis of d-myo-Inositol-1 ...
Bianca R. Sculimbrene (2204239), Scott J. Miller (1308798)   +1 more
core   +1 more source

L’importance du myo-inositol et du D-chiro-inositol pour soutenir la fertilité et la reproduction [PDF]

, 2021
International audienceThis review details the physiologic roles of two insulin sensitizers, myo-inositol (MI)and D-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle stimulatinghormone (FSH) and DCI is an aromatase inhibitor ...
Dewailly, Didier, Soulage, Christophe, Facchinetti, Fabio, Unfer, Vittorio   +3 more
core   +2 more sources

Comparing the Efficacy of Myo-Inositol Plus α-Lactalbumin vs. Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome

Metabolites, 2023
Despite the beneficial effect of myo-inositol on metabolic, hormonal, and reproductive parameters of polycystic ovary syndrome (PCOS) patients, 28% to 38% could be resistant to this treatment.
Zdravko Kamenov, Antoaneta Gateva, Simona Dinicola, Vittorio Unfer   +3 more
doaj   +1 more source

Systematic analysis of the biological roles and pharmacological properties of D-chiro-inositol [PDF]

Гинекология, 2020
D-chiroinositol (DCI) is one of the 9 inositol isomers that forms inositol phosphoglycans, which are mediators of the action of insulin. The metabolism of DCI and myo-inositol (MI) is impaired against the background of insulin resistance, including the ...
Olga A. Gromova, Ivan Yu. Torshin, Elena V. Uvarova, Natalya I. Tapilskaya, Alla G. Kalacheva   +4 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source