Results 11 to 20 of about 31,403 (255)

Inhibitors of Inositol Monophosphatase [PDF]

Journal of Enzyme Inhibition, 1999
Inositol monophosphatase (IMPase) catalyses the hydrolysis of myo-inositol monophosphates to myo-inositol, which is required in the phosphatidyl inositol cell signalling pathway. Here the enzyme structure, mechanism and inhibition of IMPase are reviewed. Lithium, an effective therapy for manic depression, is an uncompetitive inhibitor.
Fauroux, Christine M J, Freeman, Sally
core   +6 more sources

From Myo-inositol to D-chiro-inositol molecular pathways [PDF]

, 2021
OBJECTIVE: Inositol is a carbocyclic sugar polyalcohol. By epimerization of its hydroxyl groups, nine possible stereoisomers can be generated, two of major physiological and clinical relevance: Myo-inositol and D-chiro-inositol.
FACCHINETTI F., BERTELLI M., Kiani AK, Busetto GM, DINICOLA S., DI RENZO G. C., Gerli S, Calogero AE, Cannarella R, Della Morte C, BUSETTO G. M., De Berardinis E, DE BERARDINIS E., Paolacci S, Di Renzo GC, DELLA MORTE C., KIANI A. K., CANNARELLA R., Stuppia L, PAOLACCI S., GERLI S., Dinicola S, STUPPIA L., CALOGERO A. E., Del Giudice F, DEL GIUDICE F., Facchinetti F   +26 more
core   +2 more sources

Inositol Pyrophosphate Pathways and Mechanisms: What Can We Learn from Plants?

Molecules, 2020
The ability of an organism to maintain homeostasis in changing conditions is crucial for growth and survival. Eukaryotes have developed complex signaling pathways to adapt to a readily changing environment, including the inositol phosphate (InsP ...
Caitlin Cridland, Glenda Gillaspy
doaj   +1 more source

Scientific Opinion on the safety and efficacy of inositol as a feed additive for fish, dogs and cats [PDF]

EFSA Journal, 2014
Inositol is an essential micronutrient for salmon, carp, tilapia and shrimps, particularly juveniles. This conclusion is extended to all fish and crustaceans.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

Myo-Inositol as a Key Supporter of Fertility and Physiological Gestation

Pharmaceuticals, 2021
Pregnancy is a complex process, featuring several necessary changes in women’s physiology. Most women undergo healthy pregnancies; even so, several women experience reduced fertility or pathologies related to the pregnancy. In the last years, researchers
Riccardo Gambioli, Gianpiero Forte, Giovanni Buzzaccarini, Vittorio Unfer, Antonio Simone Laganà   +4 more
doaj   +1 more source

Mammalian inositol polyphosphate multikinase synthesizes inositol 1,4,5-trisphosphate and an inositol pyrophosphate [PDF]

Proceedings of the National Academy of Sciences, 2001
Using a consensus sequence in inositol phosphate kinase, we have identified and cloned a 44-kDa mammalian inositol phosphate kinase with broader catalytic capacities than any other member of the family and which we designate mammalian inositol phosphate multikinase (mIPMK).
A, Saiardi, E, Nagata, H R, Luo, A, Sawa, X, Luo, A M, Snowman, S H, Snyder   +6 more
openaire   +2 more sources

Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]

, 1991
Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
M. Gratzl, Föhr, K. J., T.P. Kemmer, Wahl, Y., K.J. Föhr, R. Engling, Engling, R., Gratzl, Manfred, Y. Wahl, Kemmer, T. P.   +9 more
core   +1 more source

A genome-wide dsRNA library screen for Drosophila genes that regulate the GBP/phospholipase C signaling axis that links inflammation to aging

BMC Research Notes, 2018
Objective Invertebrates are productive models for understanding how inflammation, metabolism and aging are intertwined. We have deployed a dsRNA library screen to search for genes in Drosophila melanogaster—and hence identify human orthologs—that encode ...
Eui Jae Sung, Stephen B. Shears
doaj   +1 more source

Effect of phytase supplementation on plasma and organ myo-inositol content and erythrocyte inositol phosphates as pertaining to breast meat quality issues in chickens

Journal of Applied Animal Nutrition, 2022
‘Woody breast’ (WB) and ‘white striping’ in broiler meat is a global problem. With unknown etiology, WB negatively impacts bird health, welfare and is a significant economic burden to the poultry industry.
H. Whitfield, C. Laurendon, S.J. Rochell, S. Dridi, S.A. Lee, T. Dale, T. York, I. Kuehn, M.R. Bedford, C.A Brearley   +9 more
doaj   +1 more source

Inositol and gradient phytase supplementation in broiler diets during a 6-week production period: 2. Effects on phytate degradation and inositol liberation in gizzard and ileal digesta contents1

Poultry Science, 2021
An experiment was conducted to evaluate effects of dietary phytase and inositol supplementation on phytate degradation in gizzard and ileal digesta contents of broilers from 1 to 43 d of age.
R. Kriseldi, C.L. Walk, M.R. Bedford, W.A. Dozier, III   +3 more
doaj   +1 more source