Results 51 to 60 of about 345,398 (296)

Brain MR Spectroscopy Changes Precede Frontotemporal Lobar Degeneration Phenoconversion in Mapt Mutation Carriers. [PDF]

, 2019
Background and purposeThe objective of this study was to longitudinally investigate the trajectory of change in 1 H MRS measurements in asymptomatic MAPT mutation carriers who became symptomatic during follow-up, and to determine the time at which the ...
Boeve, Bradley F, Boxer, Adam L, Brushaber, Danielle, Chen, Qin, Dheel, Christina, Fields, Julie, Forsberg, Leah, Gavrilova, Ralitza, Gearhart, Debra, Graff-Radford, Jonathan, Graff-Radford, Neill, Gunter, Jeffrey L, Haley, Dana, Jones, David, Kantarci, Kejal, Knopman, David, Kraft, Ruth, Lapid, Maria, Lesnick, Timothy, Rademakers, Rosa, Rosen, Howie, Tosakulwong, Nirubol, Wszolek, Zbigniew K   +22 more
core   +3 more sources

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being restricted to the confines of the ER. The reason for this compartmentalization is unclear.
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
openaire   +3 more sources

Influence of inositol on the metabolic profile in women with diabetes and other insulin-resistant conditions

Репродуктивная эндокринология
The literature review summarizes the current data on the biological properties of inositols - a natural group of polyols (sugars) classified as cyclohexanols. These compounds are widely represented in food products (cereals, legumes, nuts, seeds, melons,
L.K. Sokolova, Y.B. Belchina
doaj   +1 more source

An association of boswellia, betaine and myo-inositol (Eumastós) in the treatment of mammographic breast density. A randomized, double-blind study [PDF]

, 2015
Mammographic breast density is a recognized risk factor for breast cancer. The causes that lead to the proliferation of the glandular breast tissue and, therefore, to an increase of breast density are still unclear.
Alwasel, S. H, BIZZARRI, Mariano, CUCINA, Alessandra, Giuliani, A, Gullo, G, Harrath, A. H, PASTA, Vittorio, TARTAGLIA, Francesco   +7 more
core  

From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease

Biomolecules
Once a protein of relative obscurity, inositol polyphosphate multikinase (IPMK) emerged as a versatile and indispensable enzyme in cellular biology. With dual inositol and lipid kinase activities, IPMK generates pivotal signaling molecules such as InsP4 (
Subrata H. Mishra, Sujan Chatterjee, Loretta Viera-Preval, Prasun Guha   +3 more
doaj   +1 more source

Skeletal muscle lipids. II. Changes in phospholipid composition in man from fetal to middle age

Journal of Lipid Research, 1974
Phospholipid compositions were determined in samples of gastrocnemius muscles of individuals from fetal stage to the age of 55 yr. The lipids were separated by thin-layer chromatography. In order to enable characterization of the individual phospholipids,
Åke Bruce
doaj   +1 more source

ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Inositol phosphates (IPs) are a class of signaling molecules regulating cell physiology. The best-characterized IP, the calcium release factor IP3, is generated by phospholipase C hydrolysis of phosphoinositides lipids.
Yann Desfougères, Miranda S. C. Wilson, D. Laha, G. J. Miller, A. Saiardi   +4 more
semanticscholar   +1 more source

Disruption of INOS, a Gene Encoding myo-Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2018
Inositol is a precursor for the phospholipid membrane component phosphatidylinositol (PI), involved in signal transduction pathways, endoplasmic reticulum stress, and osmoregulation.
Natasha A. M. Jackson, Angelina M. Flores, Elizabeth D. Eldon, Lisa S. Klig   +3 more
doaj   +1 more source

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

Biomedicines, 2020
Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes.
Antonio J. López-Gambero, Carlos Sanjuan, Pedro Jesús Serrano-Castro, Juan Suárez, Fernando Rodríguez de Fonseca   +4 more
doaj   +1 more source

The Function of Inositol Phosphatases in Plant Tolerance to Abiotic Stress

International Journal of Molecular Sciences, 2019
Inositol signaling is believed to play a crucial role in various aspects of plant growth and adaptation. As an important component in biosynthesis and degradation of myo-inositol and its derivatives, inositol phosphatases could hydrolyze the phosphate of
Q. Jia, Defeng Kong, Qinghua Li, Song Sun, Junliang Song, Yebao Zhu, K. Liang, Qingming Ke, Wenxiong Lin, Jin-wen Huang   +9 more
semanticscholar   +1 more source