Results 51 to 60 of about 271,398 (373)

A Solanum tuberosum inositol phosphate kinase (StITPK1) displaying inositol phosphate–inositol phosphate and inositol phosphate–ADP phosphotransferase activities [PDF]

FEBS Letters, 2008
We describe a multifunctional inositol polyphosphate kinase/phosphotransferase from Solanum tuberosum, StITPKα (GenBank accession number: EF362784), hereafter called StITPK1. StITPK1 displays inositol 3,4,5,6‐tetrakisphosphate 1‐kinase activity: K m = 27 μM, and V max = 19 nmol min−1 mg−1.
Caddick, Samuel E. K., Harrison, Christopher J., Stavridou, Ioanna, Mitchell, Jennifer L., Hemmings, Andrew M., Brearley, Charles A.   +5 more
openaire   +4 more sources

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Social context prevents heat hormetic effects against mutagens during fish development

FEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere, Claudio Silva De Freitas, Adam Bates, Kenneth B. Storey, Pedro Beltran‐Alvarez, Katharina C. Wollenberg Valero   +5 more
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet, Riikka Immonen, Ofer Prager, Alon Friedman, Jens P. Bankstahl, David K. Wright, Terence J. O'Brien, Heidrun Potschka, Olli Gröhn, Neil G. Harris   +9 more
wiley   +1 more source

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses [PDF]

, 2001
Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling.
Berridge, Michael J., Bootman, Martin D., De Smedt, Humbert, de Smet, Patrick, Holmes, Andrew, Lipp, Peter, Missiaen, Ludwig, Parys, Jan B., Thomas, David, Thuring, Jan, Tovey, Stephen C., Young, Kenneth W.   +11 more
core  

General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. [PDF]

, 2014
Islet amyloid polypeptide (IAPP or amylin) forms amyloid deposits in the islets of Langerhans; a process that is believed to contribute to the progression of type 2 diabetes and to the failure of islet transplants.
Raleigh, David, Wang, Hui
core   +2 more sources

A native chemical chaperone in the human eye lens [PDF]

arXiv, 2020
Cataract is one of the most prevalent protein aggregation disorders and still the biggest cause of vision loss worldwide. The human lens, in its core region, lacks turnover of any cells or cellular components; it has therefore evolved remarkable mechanisms for resisting protein aggregation for a lifetime. We now report that one such mechanism relies on
arxiv  

Safety and efficacy of inositol as nutritional additive for dogs and cats

EFSA Journal, 2016
Inositol (cyclohexenehexol) is a sugar alcohol synthesised by most plants and animals. It exists in nine possible stereoisomers, four of which are physiologically active.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +1 more source

D-pinitol, a highly valuable product from carob pods: Health-promoting effects and metabolic pathways of this natural super-food ingredient and its derivatives

AIMS Agriculture and Food, 2018
D-pinitol is a natural compound related to the important family of inositols. It can be found and isolated from many plants, being the active component of ayurvedic remedies such as Talisa patra (Abies webbiana, A.
José Ignacio López-Sánchez, Diego A. Moreno, Cristina García-Viguer   +2 more
doaj   +1 more source

Phylogenetic Relationships and Potential Functional Attributes of the Genus Parapedobacter: A Member of Family Sphingobacteriaceae

Frontiers in Microbiology, 2020
The genus Parapedobacter was established to describe a novel genus within the family Sphingobacteriaceae and derives its name from Pedobacter, with which it is shown to be evolutionarily related.
Shekhar Nagar, Chandni Talwar, Shazia Haider, Akshita Puri, Akshita Puri, Kalaiarasan Ponnusamy, Madhuri Gupta, Utkarsh Sood, Utkarsh Sood, Abhay Bajaj, Abhay Bajaj, Rup Lal, Rup Lal, Roshan Kumar, Roshan Kumar   +14 more
doaj   +1 more source