Results 71 to 80 of about 31,403 (255)

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

The emergence of neuroinvasive Cryptococcus: why eucalyptus-rich regions, especially in Africa, may be facing greater risk

Frontiers in Cellular and Infection Microbiology
Cryptococcal meningitis (CM) is often approached under the assumption that Cryptococcus neoformans strains from any environment have equal potential for rapid central nervous system (CNS) invasion.
Hilaire Irere, Racheal Dangarembizi, Racheal Dangarembizi, Racheal Dangarembizi, Racheal Dangarembizi, Liliane Mukaremera, Ivy M. Dambuza   +6 more
doaj   +1 more source

Blood Biomarkers and Surface‐Enhanced Raman Spectroscopy for Gout: A Comprehensive Review

Advanced Functional Materials, EarlyView.
Schematic illustrating gout disease progression from asymptomatic hyperuricemia to chronic tophaceous disease, highlighting the limitations of conventional imaging and biochemical diagnostics and the potential of engineered SERS platforms for ultrasensitive blood‐based detection of urate‐related biomarkers across disease stages, with the color gradient
Isuri Perera, Chiranjeevi Kanike, Appurva Tiwari, Hongyan Wu, Larry D. Unsworth, Ben Bin Xu, Xuehua Zhang   +6 more
wiley   +1 more source

The Biomedical Uses of Inositols: A Nutraceutical Approach to Metabolic Dysfunction in Aging and Neurodegenerative Diseases

Biomedicines, 2020
Inositols are sugar-like compounds that are widely distributed in nature and are a part of membrane molecules, participating as second messengers in several cell-signaling processes.
Antonio J. López-Gambero, Carlos Sanjuan, Pedro Jesús Serrano-Castro, Juan Suárez, Fernando Rodríguez de Fonseca   +4 more
doaj   +1 more source

Discovery of a Catalytic Asymmetric Phosphorylation through Selection of a Minimal Kinase Mimic:  A Concise Total Synthesis of d-myo-Inositol-1-Phosphate

, 2016
Discovery of a Catalytic Asymmetric Phosphorylation through Selection of a Minimal Kinase Mimic:  A Concise Total Synthesis of d-myo-Inositol-1 ...
Bianca R. Sculimbrene (2204239), Scott J. Miller (1308798)   +1 more
core   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

L’importance du myo-inositol et du D-chiro-inositol pour soutenir la fertilité et la reproduction

, 2021
International audienceThis review details the physiologic roles of two insulin sensitizers, myo-inositol (MI)and D-chiro-inositol (DCI). In the human ovary, MI is a second messenger of follicle stimulatinghormone (FSH) and DCI is an aromatase inhibitor ...
Dewailly, Didier, Soulage, Christophe, Facchinetti, Fabio, Unfer, Vittorio   +3 more
core   +1 more source

Gestational diabetes mellitus and polycystic ovary syndrome, a position statement from EGOI-PCOS

Frontiers in Endocrinology
Gestational diabetes mellitus is a worldwide health issue in pregnancy, posing a threat to both mother and child. One of the major risk factors for the development of gestational diabetes mellitus is polycystic ovary syndrome, primarily due to the ...
Paola Quaresima, Samuel H. Myers, Basilio Pintaudi, Basilio Pintaudi, Rosario D’Anna, Rosario D’Anna, Michele Morelli, Vittorio Unfer, Vittorio Unfer   +8 more
doaj   +1 more source

The effect of hyperthermia on the phosphoinositide signalling system of tumour cells [PDF]

, 1994
The effect of heat on the phosphoinositide signalling pathway was investigated in CHO-K1 cells and WRK-1 cells. Heat caused a decrease in 1,2-diacylglycerol (1,2- DAG) levels but did not have any effect on monoacylglycerol (MAG) levels in both cell types.
Kwong, Wing Yee
core  

A Microbial Lipid‐ATP Synthase Axis Fuels NK Cell Antitumor Activity

Advanced Science, EarlyView.
This study focuses on the mechanism by which gut microbiota‐derived outer membrane vesicles (OMVs) regulate NK cell antitumor activity. B. intestinalis is identified to decrease extra‐intestinal tumor growth via its OMVs enriched in sphingosine (SP).
Kaiyuan Yu, Xinyu Sun, Wanxia Ma, Jianming Yang, Xuan Sun, Lisong Zhang, Yumeng Liu, Tianshu Ren, Qi Wang, Jingyu Wang, Xiao Li, Xianping Peng, Liu Yang, Junqiang Lv, Zhi Yao, Zhi‐Song Zhang, Quan Wang   +16 more
wiley   +1 more source